Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Short-Term 30-Day Randomized, Double-Blind, Placebo-Controlled Clinical Study

Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion

“…A number of previous researches carried on the other species, such as rat, dog, horse, and human, have shown that general human ingestion is safe across the board. 56 , 57 , 58 According to these publications and our results, Fr may be a favorable candidate for endometriosis treatment in terms of safety.…”

A Retrospective Observational Study Evaluating the Synergistic Effect of a Novel Combination of Alfapin + Native Type 2 Collagen + Mobilee (Hyaluronic Acid) + CurQlife (Curcumin) Nutraceuticals in the Symptomatic Improvement of Knee Osteoarthritis

“…Mobilee is rich in hyaluronic acid, which is a component of synovial fluid, enhances chondrocyte synthesis, prevents cartilage degradation, and promotes its regeneration [ 11 ]. Aflapin supplementation reduces the circulating matrix metalloproteinase 3 (MMP-3), tumor necrosis factor-alpha, high-sensitivity C-reactive protein, and marker of type II collagen cleavage, which affirms that Aflapin is clinically efficacious, fast-acting, and safe in treating OA with no significant adverse effects observed [ 8 ]. Curcumin downregulates the catabolic and degradative effects in chondrocytes and inhibits the production of MMP-3, MMP-9, and MMP-13, which shows the anti-arthritic potential of curcumin [ 9 ].…”

“…The efficacy of nutraceuticals in reducing OA pain is evaluated based on the Visual Analog Scale (VAS) score, range of motion, and Knee Injury and Osteoarthritis Outcome Score (KOOS). Among the myriad nutraceuticals used in OA, chondroitin sulfate, glucosamine sulfate, collagen, hyaluronic acid, Aflapin, curcumin, and methylsulfonylmethane have shown impressive results in the improvement of clinical symptoms, reducing pain and decreasing inflammation associated with OA [7][8][9].…”

Fitoterapia en Osteoartritis: Eficacia y mecanismos implicados

“…El Aflapin®, un extracto de Boswellia Serrata provee un efecto prometedor con mayor seguridad y alivios de los síntomas en la OA de la rodilla (62), así mismo el ECM de grado farmacéutico, un extracto bioactivo específico de Cúrcuma longa CURTIL02, resina de Boswellia serrata y vitamina D conocido como FlexofytolPLUS es capaz de disminuir de manera significativa el dolor crónico y brotes de OA de la mano pudiendo reemplazar a los AINES y con efecto similar al extracto de cúrcuma en relación a su efectividad y seguridad (61) Figura 1.…”