Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series

Abstract

Objective: Despite the availability of various treatment options, a large proportion of patients with asthma have uncontrolled asthma in the United states. Consequently, the economic burden of suboptimal asthma control is anticipated to substantially grow in the next 20 years, adversely impacting patients' quality of life. therefore, there is an urgent need for effective treatments to achieve and maintain asthma control. the Global Initiative for asthma recommends tiotropium as a controller medication for patients with asthma aged ≥6 years, based on evidence from several randomized controlled trials. However, more real-world data on the effectiveness of tiotropium are required to establish a broad picture of its use in everyday clinical practice. Methods: Herein, we present 3 case reports of patients diagnosed with uncontrolled or fixed obstructive asthma not responding to inhaled corticosteroids (ICs) or ICs + long-acting β 2 -agonists (LaBas) and/or leukotriene receptor antagonists (LtRas). Results: all 3 patients were prescribed tiotropium, irrespective of their age. tiotropium improved lung function and quality of life, as indicated by the forced expiratory volume in 1 s/forced vital capacity ratio and the asthma Control test score. Furthermore, the addition of tiotropium reduced the use of rescue medication. Conclusions: Hence, the results from these case reports highlight that tiotropium could be an effective and safe add-on treatment option for patients across a range of age groups with uncontrolled or fixed obstructive asthma receiving prior ICs or ICs + LaBa and/or LtRa therapy.

Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo

“…At present, the control of asthma is mainly using corticosteroids, β2-agonists and leukotriene receptor antagonists [4]. However, the effects of these therapies are not valid enough for 5-10% of severe asthma patients, and long-term use of these drugs can cause serious side effects [5]. Thus, it is crucial to find a safe anti-asthma treatments.…”