Efficacy and safety of acupuncture treatment on primary insomnia: a randomized controlled trial

Yin, Xuan; Gou, Minghui; Xu, Jian; Dong, Bo; Yin, Ping; Masquelin, F.; Wu, Jiang; Lao, Lixing

doi:10.1016/j.sleep.2017.02.012

Cited by 138 publications

(138 citation statements)

References 29 publications

Supporting

Mentioning

131

Contrasting

Order By: Relevance

“…Participants in this group will receive acupuncture treatment during the first eight weeks. According to our in depth research on insomnia and acupuncture experience, Baihui (GV20), Shenting (GV24), Yintang (GV29), Qihai (RN6), Guanyuan (RN4) and bilateral Anmian (EX-HN22), Sanyinjiao (SP6), Shenmen (HT7) will be used as main acupoints [17]. Acupuncturists will be permitted to add acupuncture points based on TCM syndrome differentiation [23].…”

Section: Methodsmentioning

confidence: 99%

“…Acupuncture, an important part of Traditional Chinese Medicine (TCM), has been used for thousands of years in China to treat various diseases including sleep disorders [5]. Many studies have confirmed the efficacy of acupuncture for primary insomnia and related depressive disorders [16][17][18]. Based on the results that the efficacy of acupuncture for depression-related insomnia [19] and insomnia following stroke [20], we believe that acupuncture might be an effective treatment for insomnia during the MT.…”

Section: Background Backgroundmentioning

confidence: 99%

See 1 more Smart Citation

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Yin

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

Background: China today has high occurrences of insomnia in perimenopausal women. Some studies have shown that acupuncture might be effective in treating primary insomnia and insomnia related to depression and stroke. Although there are some programs supporting insomnia during the menopausal transition, there are few randomized controlled trials to provide evidence regarding their effectiveness. We design a randomized controlled trial of suitable sample size to verify the effectiveness of acupuncture in patients with insomnia during the menopausal transition and to form an optimized acupuncture treatment protocol. Method/Design: In this randomized, single-site, single-blind, placebo-controlled trial, 84 eligible patients will be recruited and randomly assigned to either the acupuncture group (n = 42) or the sham control group (n = 42) in a 1:1 ratio. Participants will receive a total of 18 sessions of treatment for eight consecutive weeks. Treatments will be given three times per week in the first four weeks, twice a week for the next two weeks and finally treatment once weekly for the final two weeks. Treatment will utilize eight main acupoints (GV20, GV24, GV29, RN6, RN4, SP6, HT7, EX-HN22), and extra two acupoints based on syndrome differentiation. The primary outcome will be assessed using the Pittsburgh Sleep Quality Index (PSQI). The secondary outcomes will be measured by sleep parameters recorded in the Actigraphy (SE, TST, SA), Insomnia Severity Index (ISI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Menopause Quality of Life (Men-QOL). The primary outcomes will be assessed at baseline, week four, week eight, and first and the third month following the end of treatment. Discussion: If the results confirm that acupuncture is effective and safe for the treatment on insomnia in menopausal women, this positive outcome could provide evidence for clinical application.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Background Backgroundmentioning

confidence: 99%

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Yin

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The acupuncture group: Participants in this group will receive acupuncture treatment during the first eight weeks. According to our in depth research on insomnia and acupuncture experience, Baihui (GV20), Shenting (GV24), Yintang (GV29), Qihai (RN6), Guanyuan (RN4) and bilateral Anmian (EX-HN22), Sanyinjiao (SP6), Shenmen (HT7) will be used as main acupoints [17]. Acupuncturists will be permitted to add acupuncture points based on TCM syndrome differentiation [23].…”

Section: Interventionmentioning

confidence: 99%

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Yin

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Background China today has high occurrences of insomnia in women experiencing menopausal transition. Some studies have shown that acupuncture might be effective in treating primary insomnia and insomnia related to depression and stroke. Although there are some programs supporting insomnia during the menopausal transition, there are few randomized controlled trials to provide evidence regarding their effectiveness. We design a randomized controlled trial of suitable sample size to verify the effectiveness of acupuncture in patients with insomnia during the menopausal transition and to form an optimized acupuncture treatment protocol. Method/Design In this randomized, single-site, single-blind, placebo-controlled trial, 84 eligible patients will be recruited and randomly assigned to either the acupuncture group (n = 42) or the sham control group (n = 42) in 1:1 ratio. Participants will receive 18 sessions of treatment in total for eight consecutive weeks. Treatments will be given three times per week in the first four weeks and then twice a week for the next two weeks followed by once a week treatment for the final two weeks. Treatment will utilize eight main acupoints (GV20, GV24, GV29, RN6, RN4, SP6, HT7, EX-HN22), and extra two acupoints based on syndrome differentiation. The primary outcome will be assessed using the Pittsburgh Sleep Quality Index (PSQI). The secondary outcomes will be measured by sleep parameters recorded in the Actigraphy (SE, TST, SA), Insomnia Severity Index (ISI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Menopause Quality of Life (Men-QOL). The primary outcomes will be assessed at baseline, four-week, eight-week, and first and the third month after the end of treatment. Discussion If the results confirm that acupuncture is effective and safe for the treatment on insomnia in menopausal women, they could provide evidence for clinical application.

show abstract

“…There is no known sample size calculation for fMRI research [21]. However, for the exploratory and pilot studies study, 10…”

Section: Sample Sizementioning

confidence: 99%

“…Therefore, some patients have sought alternative treatments. Acupuncture, a critical component of Traditional Chinese Medicine, may relieve the symptoms of insomnia [7][8][9][10]. Nevertheless, the underlying neural basis for the effects of acupuncture remains largely unknown.…”

mentioning

confidence: 99%

Acupuncture for patients with insomnia disorder using resting-state functional magnetic resonance imaging: a protocol for a Randomised Controlled Trial

Guo

Liu

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Insomnia is among the most prevalent sleep-related disorders. Insomnia disorder is associated with a brain hyperarousal state manifested by abnormal regional brain activity and resting-state functional connectivity (rs-FC). Acupuncture improves sleep quality and modulates the hyperarousal state; however, the underlying neurobiological basis for improved sleep quality is poorly understood. The purpose of this clinical trial is to study the efficacy of acupuncture in the treatment of insomnia disorder. In addition, the neural mechanism by which acupuncture affects insomnia disorder will be explored utilizing resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological parameters. Methods and Design: A randomized, patient-assessor-blinded trial will be conducted. We will randomize (1:1 ratio) 60 eligible patients with insomnia disorder into a real acupuncture group or a sham acupuncture group. Interventions will be administered three times per week over a 4 week period, with an 8 week follow-up period. The healthy control group will consist of 30 age- and sex-matched healthy good sleepers without any treatment intervention. All participants will undergo neuropsychological and rs-fMRI evaluations. The change of Pittsburgh Sleep Quality Index (PSQI) scores is the primary outcome parameter. The secondary outcome parameters include the Hyperarousal scale (HAS), rs-fMRI measurements, the Fatigue scale-14 (FS-14), the Hamilton depression scale (HAMD), the Hamilton anxiety scale (HAMA), a sleep diary, and an actigraph. Assessment of all parameters will be performed at baseline, post-treatment, and during follow-up. Analyses will be implemented based on intention-to-treat. Discussion: The study results will be utilized to clarify the effectiveness and elucidate the mechanism by which acupuncture improves sleep quality in patients with insomnia disorder.

show abstract

Efficacy and safety of acupuncture treatment on primary insomnia: a randomized controlled trial

Abstract: Chinese Clinical Trial Registry: Chi CTR-TRC-14004859.

Cited by 138 publications

References 29 publications

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Effect of acupuncture on insomnia in menopausal women: A Study protocol for a Randomized Controlled Trial

Acupuncture for patients with insomnia disorder using resting-state functional magnetic resonance imaging: a protocol for a Randomised Controlled Trial

Contact Info

Product

Resources

About