Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis

Zhou, Weimei; Su, Jiewen; Zhang, Hongjie

doi:10.1089/acm.2014.0400

Cited by 38 publications

(35 citation statements)

References 31 publications

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“…Acupuncture has long been used in China to treat FD, and it has been used in some Western countries as an optional treatment for gastrointestinal diseases due to its high efficacy and safety [4][5][6]. Studies have shown that RN12, ST36, ST37, PC6, ST25, and BL21 are principal acupoints for the treatment of gastrointestinal diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture at Gastric Back‐Shu and Front‐Mu Acupoints Enhances Gastric Motility via the Inhibition of the Glutamatergic System in the Hippocampus

Wang

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Acupuncture strongly alleviates gastrointestinal symptoms and especially promotes gastrointestinal motility. However, the mechanism underlying these processes is poorly understood. is study was designed to examine the effect of electroacupuncture (EA) at gastric back-shu (BL21) and front-mu (RN12) acupoints on gastric motility in functional dyspepsia (FD) rats and to investigate the mechanisms of its effects on the glutamatergic system in the hippocampus. We found that EA at RN12 or BL21 enhanced gastric motility in FD rats, whereas EA at the combination of RN12 and BL21 showed an additional effect. Microdialysis combined with HPLC showed that EA reduced the glutamate content in the hippocampus, and the NMDAR-NO-cGMP signalling pathway was downregulated, as determined by Western blot assays, in FD rats. In addition, we found that decreased gastric motility was significantly restored by the hippocampal infusion of an NMDAR, nNOS, or sGC antagonist. Interestingly, EA had no further effects on gastric motility in the presence of these antagonists in FD rats. Taken together, these results suggest that the hippocampal glutamatergic system is involved in the regulation of gastric motility by EA at RN12 and BL21.

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Section: Introductionmentioning

confidence: 99%

Acupuncture at Gastric Back‐Shu and Front‐Mu Acupoints Enhances Gastric Motility via the Inhibition of the Glutamatergic System in the Hippocampus

Wang

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…There have been several articles on the meta-analysis of the acupuncture treatment for FD. One article reported that there was no significant difference between domperidone and manual acupuncture in improving symptom scores (RR: (Zhou WM et al, 2016). In addition, we also performed frequency analysis and cluster analysis on 60 acupuncture prescriptions of 31 RCTs, the results showed that ST35, P6, CV12, ST25, LR3, BL21,, BL2, CV6, LR14 and CV10 were the most frequently used acupoints, and ST36, P6, CV12；ST25, BL20, BL21；LR14, LR2, BL18, LR3；SP9，ST44 were the main acupoints groups treating for FD.…”

Section: Frequency Analysis Of Acupointmentioning

confidence: 99%

Efficacy of Manual Acupuncture on Functional Dyspepsia: A Meta-Analysis of Randomized, Controlled Trials

Yuan¹,

Wang²,

Yang³

et al. 2017

Afr J Tradit Complement Altern Med

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“…In recent years, several systematic reviews [19][20][21][22] have shown that different acupuncture therapies effectively improve functional dyspepsia, even better than conventional drugs. So far, many types of acupuncture therapies have been developed, including manual acupuncture [23], warm acupuncture [24], electroacupuncture [25], moxibustion [26], acupoint catgut embedding [27], and acupoint application [28].…”

Section: Introductionmentioning

confidence: 99%

“…So far, many types of acupuncture therapies have been developed, including manual acupuncture [23], warm acupuncture [24], electroacupuncture [25], moxibustion [26], acupoint catgut embedding [27], and acupoint application [28]. Previous systematic reviews [19][20][21][22] have only evaluated the efficacy of different acupuncture therapies as a whole in comparison with conventional drugs. In 2017, Ho et al conducted a systematic review and network metaanalysis on acupuncture and other related therapies for functional dyspepsia.…”

Section: Introductionmentioning

confidence: 99%

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

Zhang

Liu

Huang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Acupuncture has been found to be an effective treatment for functional dyspepsia (FD). Currently, several types of acupuncture have been developed but it is not clear which type is suitable for FD. Currently, doctors often rely on experience to decide which form of acupuncture to apply. Herein, we employed network meta-analysis (NMA) to compare the effectiveness of various methods of acupuncture in the treatment of functional dyspepsia. Methods. We searched for randomized controlled trials (RCTs) of acupuncture treatments for functional dyspepsia in seven databases; PubMed, the Cochrane Library, Embase, Wanfang database, China National Knowledge Infrastructure (CNKI) database, Chinese Science and Technique Journals (CQVIP), and Chinese Biomedical Database (CBM) from the date of database inception to October 10, 2019. Cochrane risk of bias tool was used to analyze the risk of bias of the included RCTs. Pairwise meta-analyses were performed with RevMan 5.3 and the network metaanalysis of the included RCTs was performed using the frequentist framework. Results. A total of 35 studies involving 3301 patients and 10 interventions were eligible for this study. NMA results showed that five types of acupuncture (manual acupuncture, acupoint application, moxibustion, acupoint catgut embedding, and warm acupuncture alone) all were superior to prokinetics (itopride, mosapride, and domperidone) and sham acupuncture in terms of improving the symptoms of functional dyspepsia. Specifically, manual acupuncture and electroacupuncture were more effective in improving the MOS 36 Item Short-Form Health Survey (SF-36) compared to itopride and sham acupuncture, and electroacupuncture was the best among the three acupuncture therapies (acupuncture, electroacupuncture, and acupoint catgut embedding). Moxibustion and manual acupuncture were more effective in improving Nepean Dyspepsia Life Quality Index (NDLQI) compared to itopride, domperidone, and sham acupuncture; moxibustion ranks first among the three acupuncture therapies (acupuncture, electroacupuncture, moxibustion). Conclusions. ese results showed that manual acupuncture alone was the most effective therapy for FD. It should, therefore, be considered as an alternative treatment for FD patients who are unresponsive to prokinetics or intolerant to the adverse effects of prokinetics. We recommend further multiple centers and high-quality RCT studies to confirm the present findings.

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Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis

Abstract: Acupuncture appears to be efficacious in relieving FD symptoms and improving quality of life.

Cited by 38 publications

References 31 publications

Acupuncture at Gastric Back‐Shu and Front‐Mu Acupoints Enhances Gastric Motility via the Inhibition of the Glutamatergic System in the Hippocampus

Acupuncture at Gastric Back‐Shu and Front‐Mu Acupoints Enhances Gastric Motility via the Inhibition of the Glutamatergic System in the Hippocampus

Efficacy of Manual Acupuncture on Functional Dyspepsia: A Meta-Analysis of Randomized, Controlled Trials

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

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