Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients

Mohamed, Amal Ahmed; Hussein, Maha S.; Ahmed, Eman M.; Eldemery, Ahmed; Darwish, Mona; Ghaith, Doaa; Attala, Rasha A.; Borolossy, Radwa El

doi:10.1080/09546634.2020.1762838

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…Recent experiments have shown that vitamin D is significantly negatively correlated with urticarial activity and vitamin D supplementation can significantly improve the quality of life of CSU patients and reduce the severity of the disease. Therefore, vitamin D can be used as a new type of drug for the treatment of CSU [82][83][84].…”

Section: Vitamin D3/vitamin D-binding Proteinmentioning

confidence: 99%

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

Zhang

et al. 2021

Int Arch Allergy Immunol

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Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis edema, erythema, pruritus, or burning sensation). According to whether the natural course exceeds 6 weeks, urticaria can be divided into acute and chronic urticaria (CU). At present, the evaluation of CU activity mainly depends on the Urticaria Activity Score (UAS), but the evaluation indicators are relatively single, and we need more reliable experimental data for evaluation. We typically summarize advanced biomarkers and several related pathogenic pathways discovered in recent years on urticaria, including the cell adhesion/chemotaxis pathway, interleukin (IL)-6/Janus tyrosine kinase/STAT pathway, IL-17/IL-23 pathway, basophil- and mast cell-related pathway, coagulation/fibrinolysis-related pathways, single-nucleotide polymorphism, and some other pathways. This review aims to find appropriate biomarkers so that we can evaluate disease activity, discover novel therapeutic targets, and predict the patients’ response more accurately to therapeutic agents.

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Section: Vitamin D3/vitamin D-binding Proteinmentioning

confidence: 99%

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

Zhang

et al. 2021

Int Arch Allergy Immunol

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“…Dietary elimination of fish or fish products and mammalian meat or meat products has Grade B recommendation each, while dietary elimination of gluten has Grade C recommendation (Table 3 ) 16,17,19–22,24–41 . However, elimination diets may be tried in a subset of refractory CSU patients, for example, those with a history of anaphylaxis, resident of tick endemic areas for AGS, or confirmed coexistence of food allergy by a double‐blind placebo‐controlled food challenge, when benefits outweigh risks.…”

Section: Elimination Dietsmentioning

confidence: 99%

“…Dietary elimination of fish or fish products and mammalian meat or meat products has Grade B recommendation each, while dietary elimination of gluten has Grade C recommendation (Table 3). 16,17,[19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] However, elimination diets may be tried in a subset of refractory CSU patients, for example, those with a history of anaphylaxis, resident of tick endemic areas for AGS, or confirmed coexistence of food allergy by a double-blind placebo-controlled food challenge, when benefits outweigh risks. These diets are easy to follow but may lead to nutritional insufficiency, for example, elimination of fish neutralizes the benefits of fish in hyperlipidemic patients.…”

Section: Authors' Commentsmentioning

confidence: 99%

“…53 Based on these reports, several authors have proposed vitamin D supplementation as an add-on therapy to improve the clinical outcome of refractory CSU patients. Notably, most studies have found supplementary vitamin D therapy to be a safe and effective treatment option for recalcitrant CSU patients, in addition to their conventional therapy, especially those having inherent vitamin D deficiency [35][36][37] (Table 3).…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

“…Studies concerning dietary modification in CSU16,17,[19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] …”

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confidence: 99%

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Dietary strategies for chronic spontaneous urticaria: an evidence‐based review

2021

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Although the relationship between diet and chronic spontaneous urticaria (CSU) remains elusive, several patients seek dietary modifications as they are easy and cost-effective.Adequate patient education and counseling are crucial as modified diets may be beneficial for a subset of antihistamine refractory CSU patients, and no modality currently exists to identify these patients. Elimination of food items based exclusively on patient history may lead to unnecessary restrictions in most cases resulting in nutritional deficiencies and impaired quality of life. Several dietary strategies have been tried till date with varying rates of success and evidence. This review highlights the various dietary strategies along with their levels of evidence, which may help the treating dermatologists and physicians to counsel CSU patients and make evidence-based treatment decisions. There is grade A recommendation for the elimination of food additives (artificial pseudoallergens), personalized diets, vitamin D supplementation, Diamine oxidase supplementation and probiotics (in children), grade B recommendation for dietary elimination of red meat, fish and their products, natural pseudoallergens (fruits, vegetables, and spices), and lowhistamine diet, while dietary elimination of gluten (with concomitant celiac disease) has grade C recommendation. Notably, elimination diets should be continued for at least 3 consecutive weeks to assess their effectiveness.

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