2017
DOI: 10.3389/fmicb.2017.02348
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Efficacy and Safety of a Bovine-Associated Staphylococcus aureus Phage Cocktail in a Murine Model of Mastitis

Abstract: Overuse of antibiotics is a major problem in the treatment of bovine mastitis, and antibiotic treatment is frequently non-curative, thus alternative treatments are necessary. The primary aim of this study was to evaluate the efficacy of a purified phage cocktail for treatment of bovine Staphylococcus aureus mastitis in a well-defined mouse model. Candidate phages were selected based on their in vitro performance and subsequently processed into an optimally composed phage cocktail. The highest scoring phages we… Show more

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Cited by 64 publications
(55 citation statements)
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“…It may therefore be useful to develop cocktails consisting of different bacteriophages or to supplement the phage therapy with endolysins. The expansion of the working spectrum has already been tested and confirmed by two recent studies (Porter et al, 2016;Breyne et al, 2017). The main disadvantage of the classical endolysins remains their Gram-positive spectrum.…”
Section: Critical Comments and Future Pros-pectsmentioning
confidence: 68%
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“…It may therefore be useful to develop cocktails consisting of different bacteriophages or to supplement the phage therapy with endolysins. The expansion of the working spectrum has already been tested and confirmed by two recent studies (Porter et al, 2016;Breyne et al, 2017). The main disadvantage of the classical endolysins remains their Gram-positive spectrum.…”
Section: Critical Comments and Future Pros-pectsmentioning
confidence: 68%
“…A selected phage cocktail for the treatment of S. aureus-associated (Newbould 305) bovine mastitis has recently been tested in vitro and in a mouse model (Breyne et al, 2017). First, different cultures were verified in the presence or absence of IgG and the phage cocktail.…”
Section: In Vitro and In Vivo Evaluation Of Bacteriophages In The Conmentioning
confidence: 99%
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“…saw a reduction in the bacterial load in mammary tissue in comparison with the phage‐free control. An improvement in mammary gland pathology was also observed post‐treatment (Breyne et al ). A similar study by Iwano et al .…”
Section: Veterinary Applications Of Phages In Dairy Productionmentioning
confidence: 86%
“…S. aureus , one of the etiological agents for mastitis, which has a propensity to recur chronically, causes a potentially fatal inflammatory response in gland tissues. In an experimental model, lactating mice intramammarily infected with a clinical bovine S. aureus strain showed significant improvement in mammary gland pathology and a 4-log reduction in bacterial load after phage treatment [ 32 ]. However, compared to the antibiotic cefalonium, the phage treatment was far less effective.…”
Section: Bacteriophages In Food Animal Productionmentioning
confidence: 99%