Efficacy and safety of a polyherbal formulation in hemorrhoids

Abstract

Background:The medical management of hemorrhoids should include an integrated approach. This integrated approach can be achieved by polyherbal formulations containing anti-inflammatory, styptics, analgesics, and laxative effect which reduce inflammation, pain, and bleeding, and increase gastro-intestinal motility and soften stools. One such polyherbal kit is “Arshkeyt™, a 7 day kit,” which consists of oral tablets and powder along with topical cream.Objective:Efficacy and safety of Arshkeyt™, a 7 day kit, a marketed polyherbal formulation was evaluated in comparison with conventional therapy practiced in surgery outpatient departments.Materials and Methods:Patients (n = 90) with hemorrhoids were randomly allocated to receive either Arshkeyt™ or standard therapy (combination of oral Isabgul powder and 2% lidocaine gel) for 14 days. Assessment on the basis of rectal symptoms and proctoscopic examination was done on day 0, 7, and 14 to derive a “composite score” which ranged from 0 to 25 by a blinded evaluator. The primary endpoint was number of patients achieving composite score 0 at the end of therapy (day 14). Inter-group analysis was done using Chi-square test.Results:On day 14, the composite score of 0 was achieved in 15 patients of Arshkeyt™ group versus 6 patients receiving standard therapy. The symptoms and signs which showed significant improvement in Arshkeyt™ group compared to standard treatment group were the tenesmus (visual analog score) score (P = 0.047), anal sphincter spasm (P = 0.0495) and a decrease in the grade of hemorrhoids (P = 0.0205) on day 14. Arshkeyt™ was also more beneficial in case of bleeding hemorrhoids as compared to nonbleeding hemorrhoids (P < 0.05). The incidence of adverse drug reactions in both groups was comparable and no patient required any treatment for the same.Conclusion:“Arshkeyt™, a 7 day kit,” was effective in the treatment of hemorrhoids and had a good safety profile.

A Pilot, Prospective, Randomized-Controlled Study to Evaluate the Efficacy and Safety of Arsha Hita™ in the Treatment of Anal Fissures

“…In this study, a combination of Arsha Hita tablets and Arsha Hita ointment was found to be an effective initial treatment option for anal fissures that doesn't require surgery. The tablets contain ingredients such as Arishtak (Sapindus trifoliatus) and Soorana (Amorphophallus campanulatus), which have anti-inflammatory properties, while Sarja (Vateria indica) helps with wound healing [4][5][6]. The Arsha Hita ointment used in the study contains Tila Taila or Sesame oil, which is known for its wound healing and analgesic properties.…”

“…Arishtak and Soorana have been specifically noted for their anti-inflammatory actions. Sarja, on the other hand, contributes to the wound-healing action [4][5][6]. On the other hand, Arsha Hita ointment is formulated with Tila Taila or sesame oil (Sesamum indicum), which has wound-healing and analgesic properties [7].…”

“…Additionally, Madhoochchhishta (Bee's wax) contains anti-inflammatory, wound healing, and styptic properties [ 9 ]. Similar to Arsha Hita tablets, Arsha Hita ointment also contains Sarja, which further helps speed up wound healing [ 6 ].…”

Treatment of haemorrhoids with individualized homoeopathy: an open observational pilot study

“…However, the true burden of disease is difficult to capture as many patients are reluctant to seek medical suggestions for various personal, cultural, and socio-economic reasons [ 2 , 6 , 7 ]. The prevalence of hemorrhoids in India according to recent surveys is around 40 million [ 8 ]. Several risk factors have been claimed to be the etiologies of hemorrhoid development including aging, obesity, depression, pregnancy, chronic constipation and diarrhea, low-fiber diet, spicy foods, and alcohol intake [ 9 ].…”

Treatment of hemorrhoids with individualized homeopathy – an open observational pilot study

“…However, the true burden of disease is difficult to capture as many patients are reluctant to seek medical suggestions for various personal, cultural, and socio-economic reasons [2,6,7]. The prevalence of hemorrhoids in India according to recent surveys is around 40 million [8]. Several risk factors have been claimed to be the etiologies of hemorrhoid development including aging, obesity, depression, pregnancy, chronic constipation and diarrhea, lowfiber diet, spicy foods, and alcohol intake [9].…”