Efficacy and safety of a standardized extract from Achillea wilhelmsii C. Koch in patients with ulcerative colitis: A randomized double blind placebo-controlled clinical trial

Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects

“…Herein, we report the results of a comprehensive phytochemical investigation of A. wilhelmsii aerial part that led to the identification of 17 secondary metabolites (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), including the not yet described sequiterpenoids wilhelmsin (7) and wilhelmsolide (9). The structural elucidation for these new secondary metabolites, including peculiar structural features, was as well performed.…”

“…This plant holds a remarkable place in traditional Persian medicine, with a particular indication for the treatment of pulmonary affections, and it is used by the local population for a variety of ailments [4]. Recent investigations have substantiated these traditional uses with a scientific approach and activity on irritable bowel syndrome and ulcerative colitis [5,6], and improvement of oxidative stress-related myocardial injury [7] have been demonstrated. Asgary et al [8] have reported a significant activity of A. wilhelmsii extracts in inducing a decrease in triglycerides and LDL-cholesterol levels after 2-4 months of the administration, a result supported by Khazneh et al [9] in a more recent investigation.…”

The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double‐blinded, placebo‐controlled trial

“…Indeed, growing evidence posits that the use of herbal medicines, and their extracted compounds, with protective and antioxidant properties, can also be effective and safe for the management of ulcerative colitis disease. [15][16][17][18][19][20] For instance, nigella sativa, 15 silymarin, 16 ginger, 17 ferulago, 21 curcumin 18 and resveratrol 19 have been shown as potentially effective agents in improving, managing or ameliorating ulcerative colitis and/or its accomonaying comorbidities. Spirulina (Arthrospira platensis), as eco-friendly cyanobacterium (Oscillatoriaceae family), is a spiral blue-green microalgae, 22,23 which is edible and widely consumed as food or nutritional supplement.…”