Efficacy and Safety of 0.05 % Cyclosporine Ophthalmic Microemulsion for the treatment of Moderate to Severe Dry Eye Disease – an Indian Experience

Goel, Upsham

doi:10.7869/djo.115

Cited by 2 publications

(1 citation statement)

References 21 publications

(30 reference statements)

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“…In vivo studies on human individuals have proved that cyclosporine MEs are superior than the conventional formulations in terms of efficacy and safety. 60,61 Gan et al aimed to design a new type of ME based on in situ electrolyte-responsive gel system for ocular administration of CysA. To prepare the ME, castor oil as oil, Solutol HS 15 as surfactant and glycerol as co-surfactant, and water were used.…”

Section: Characterization Of Mesmentioning

confidence: 99%

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

Okur

Çağlar

Sıafaka

2020

Journal of Ocular Pharmacology and Therapeutics

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Sufficient ophthalmic drug delivery is still challenging for pharmaceutical technologists, despite various scientific efforts. Several ocular drug carriers have been designed to enhance bioavailability by prolonging the drug retention time. One of the current encouraging approaches is the utilization of colloidal carriers with the characteristic submicron-nanometer size. Microemulsions (MEs) are such colloid systems that present sizes between 5 and 200 nm with significant thermodynamic stability and low surface tension. In addition, MEs as topical ocular carriers can lead to great ocular drug adsorption due to their enhanced retention time. Furthermore, considering that MEs are stable for long time and various temperatures, their ocular application is of great interest. The aim of this study is to cover basic physicochemical principals of ocular MEs such as their possible size, stability, and therapeutic efficacy against various eye disorders. Thus, a comprehensive review for ocular drug delivery systems in the form of MEs that show promising characteristics as their stability and therapeutic efficiency is performed.

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Section: Characterization Of Mesmentioning

confidence: 99%