Efficacy and Safety Evaluation of Taohong Siwu Decoction (桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

Tao, Tianqi; Mao, Huimin; Xia, Lei; Liu, Xiu-Hua

doi:10.1007/s11655-019-3028-4

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…TCM therapy reportedly decreased the blood stasis syndrome scores and the rehospitalization rate during the 6-month follow-up in angina [19]. It has been revealed THSWD combined with conventional treatments demonstrated a potential benefit in relieving angina pectoris without adverse events [16]. However, there is an urgent need to define the effects of TCM therapy in MI.…”

Section: Discussionmentioning

confidence: 99%

“…No obvious adverse events were reported in most THSWD clinical trials. The combination of THSWD with conventional therapy to treat patients with angina pectoris resulted in headaches in the combination group and control group [16]. Moreover, other adverse events associated with THSWD may include nausea, diarrhea or abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

“…Another study suggested that THSWD could improve the microcirculation in the femoral head in rabbits by promoting the expression of vascular endothelial growth factor (VEGF) [15]. In clinical practice, THSWD combined with conventional treatment demonstrated a potential benefit in relieving angina pectoris without significant adverse events [16]. However, to the best of our knowledge, the efficacy and safety of THSWD in MI therapy remains unelucidated.…”

Section: Introductionmentioning

confidence: 99%

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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction

Luo

Xiao

et al. 2019

Cardiology Research and Practice

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Cardiovascular disease has been established as a major cause of morbidity and mortality worldwide, resulting in a huge burden to patients, families, and society. Traditional Chinese Medicine (TCM) presents several advantages for the prevention and treatment of cardiovascular diseases including multitargets, multi-ingredients, fewer side effects, and low cost. In this study, a rat model of myocardial infarction (MI) was established by ligating the anterior descending branch of the left coronary artery, and the effect of the Taohong Siwu decoction (THSWD) on cardiac function was evaluated in MI rats. Following the intragastric administration of THSWD, the cardiac function was examined using echocardiography. The infarct size and collagen deposition in the infarct area were measured using Masson's trichrome staining, and the number of CD31- and α-SMA-positive blood vessels in the peri-infarct and infarct area was evaluated by immunofluorescent staining. The mRNA expression of bFGF, IGF-1, and HGF was detected using RT-PCR assay. Cell apoptosis in the infarcted area was assessed by TUNEL staining, and the p-Akt level was detected using the western blot assay. The mitochondrial ROS production was measured using MitoSOX staining, and mitochondrial dynamics and mitophagy were evaluated with western blotting 7 days after THSWD treatment. THSWD increased the ejection fraction (EF) and fractional shortening (FS) values in the rat hearts; however, no statistical difference was found between the THSWD and MI groups 4 weeks after treatment. Furthermore, THSWD significantly decreased the value of the left ventricular end-systolic volume (LVESV). Compared with the model group, THSWD significantly increased the expression of IGF-1 and bFGF, reduced collagen deposition, promoted angiogenesis, reduced cell apoptosis, and activated the PI3K/Akt signaling pathway. Notably, THSWD significantly decreased mitochondrial ROS production and Fis1 expression. No statistical differences were observed in the expression of mitochondrial LC3B and Mfn1 between the THSWD and control groups. In summary, THSWD may possess a beneficial effect on cardiac function by improving the local ischemic microenvironment and by decreasing mitochondrial fission after MI. Hence, this may present a promising auxiliary strategy in the treatment of ischemic cardiomyopathy such as MI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction

Luo

Xiao

et al. 2019

Cardiology Research and Practice

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“…It is composed of the following Chinese medicinal herbs: Tao Ren, Dang Gui, Chuan Xiong, Hong Hua, Chi Shao, and Sheng Di. According to the previous studies, THSWD improves angina symptoms, reduces blood lipids, and promotes anticoagulation (Ma et al, 2018;Tao et al, 2019). Other reports confirmed that THSWD improved microcirculation, protected the endothelial cells, and decreased the level of inflammatory factors (Liu et al, 2013).…”

Section: Introductionmentioning

confidence: 89%

Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment

Tao

Mao

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of THSWD is still unclear. To comprehensively understand the material foundation of the "blood", it is significantly important to study the differential metabolites involved in the treatment of CHD with Chinese medicinal herb promoting blood circulation in TCM theory. Hence, this study investigated the metabolic profiles of the serum in CHD patients to determine the differential metabolites between the THSWD group and the placebo group. Eleven CHD patients were recruited and divided into two groups randomly and double-blindly. Serum samples were determined by performing non-targeted ultra-performance liquid chromatography with tandem mass spectrometry-based metabolomics. Pearson's correlation analysis was used to assess the association between identified metabolites and clinical serum indexes of CHD. Based on the result, a total of 513 metabolites were found in the serum of CHD patients, of which 27, involved in 29 metabolic pathways, were significantly different between the two groups. Among the differential metabolites, THSWD upregulated succinylcarnitine in fatty acid metabolism and 5′-methylthioadenosine in cysteine and methionine metabolism compared with the placebo group. However, THSWD downregulated pelargonic acid, involved in FA metabolism; succinate, involved in the tricarboxylic acid cycle; gluconic acid, gluconolactone, and D-glucose, involved in pentose phosphate pathway; glycerophosphocholine, involved in glycerophospholipid metabolism; 8,9-dihydroxyeicosatrienoic acid (8,9-DiHETrE), L-lysine, N-acetyl-L-aspartic acid, N-alpha-acetyl-L-asparagine, hippurate, indoxyl sulfate, and 3-ureidopropionate involved in amino acid metabolism compared with the placebo group. Moreover, succinylcarnitine, pelargonic acid, succinate, D-glucose, gluconic acid, L-lysine, N-alpha-acetyl-L-asparagine, 5′-methylthioadenosine, indoxyl sulfate, 8,9-DiHETrE, and 3-ureidopropionate were associated with total cholesterol or low-density lipoprotein. Succinylcarnitine, pelargonic acid, gluconolactone, N-acetyl-L-aspartic acid, N-alphaacetyl-L-asparagine, hippurate, and 5′-methylthioadenosine were associated with

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“…There were 19 systematic reviews [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98] meeting the selection criteria with 9 unique outcomes (Fig. 8).…”

Section: Angina Pectorismentioning

confidence: 99%

The efficacy of traditional Chinese herbal medicine across multiple cardiovascular diseases: an umbrella review of systematic reviews of randomized controlled trials

Li,

Yu,

Jiang

et al. 2024

Journal of Cardiovascular Pharmacology

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Traditional Chinese herbal medicine (CHM) has been extensively used in cardiovascular disease in modern clinical practice, alone or in combination with conventional treatment. However, its efficacy has not been assessed extensively. From inception until August 2023, we systematically searched five public literature databases to conduct the umbrella review. The inclusion criterion is systematic reviews of randomized controlled trials investigating the effect of CHM in the contemporary management of cardiovascular diseases. The quality of the included systematic reviews, the certainty of the evidence, and the potential risk of bias were assessed. Five hundred and thirty-nine systematic reviews, including 346 studies in Chinese and 193 in English, were selected before the quantitative synthesis. The methodological quality was generally moderate, with a median value of 11. The favorable efficacy of CHM was primarily presented on five main conditions, coronary artery disease, hypertension, heart failure, restenosis, and angina pectoris. CHM, with or without conventional treatment, showed a consistent beneficial effect in various cardiovascular diseases. Nevertheless, the magnitude of the effect requires further investigation as the lack of relevant research and the complexity of the clinical practice of CHM.

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Efficacy and Safety Evaluation of Taohong Siwu Decoction (桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

Cited by 13 publications

References 6 publications

Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction

Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction

Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment

The efficacy of traditional Chinese herbal medicine across multiple cardiovascular diseases: an umbrella review of systematic reviews of randomized controlled trials

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