Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells
Wenhao Niu,
Binchen Wang,
Yirui Zhang
et al.
Abstract:IntroductionFibroblast activation protein (FAP) overexpression on cancer-associated fibroblasts (CAFs) is associated with poor prognosis and worse clinical outcomes. Selective ablation of pro-tumorgenic FAP+ stromal cells with CAR-T cells may be a new therapeutic strategy. However, the clinical use of FAP-CAR T cells is suggested to proceed with caution for occasional poor efficacy and induction of on-target off-tumor toxicity (OTOT), including lethal osteotoxicity and cachexia. Hence, more investigations and … Show more
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