Efficacy and safety between early use and late use of celecoxib in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study

Pu, Chunxue; Jiang, Xue; Sun, Ying; Lin, Hui; Shao-chen, LI

doi:10.1007/s10787-021-00880-1

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Specifically, compared with the other two groups, the iguratimod group had remarkably lower VAS scores ( P < 0.05); compared with the diclofenac sodium group, the celecoxib group had signally lower VAS scores ( P < 0.05). These results were in line with the research report of PU CHUNXUE et al [ 25 ], confirming that all the NSAIDs had good analgesic effects and iguratimod had a better analgesic effect compared with the other two drugs. After treatment, the inflammatory factor levels of IL-6, TNF- α , and hs-CRP in the diclofenac sodium group were observably higher compared with the celecoxib group ( P < 0.05), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group ( P < 0.05).…”

Section: Discussionsupporting

confidence: 92%

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Jiang

Zhang

Huang³

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effects of different nonsteroidal anti-inflammatory drugs combined with platelet-rich plasma on inflammatory factor levels in patients with osteoarthritis. Methods. The clinic data of 120 patients with osteoarthritis who were treated in our hospital (June 2019-June 2021) were retrospectively reviewed. All the patients were given platelet-rich plasma. According to the different nonsteroidal anti-inflammatory drugs the patients received, they were equalized into diclofenac sodium group, celecoxib group, and iguratimod group, with 40 cases in each group. After treatment, the patients’ clinical efficacy was compared and analyzed. Results. After treatment, the pain degrees of the patients in the three groups were gradually reduced. After 4 weeks and 8 weeks of treatment, the statistical differences in the scores of Visual Analogue Scale (VAS) were found among the three groups. Specifically, compared with the other two groups, the iguratimod group had remarkably lower VAS scores ( P < 0.05 ) and the celecoxib group had signally lower VAS scores compared with the diclofenac sodium group ( P < 0.05 ). After treatment, the inflammatory factor levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in the diclofenac sodium group were observably higher compared with the celecoxib group ( P < 0.05 ), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group ( P < 0.05 ). Before treatment, no notable difference in the Lysholm scores was found among the three groups, and the patients’ knee joint function was gradually improved after treatment. To be specific, after 4 and 8 weeks of treatment, the iguratimod group had observably higher Lysholm scores compared with the other two groups ( P < 0.05 ), and the celecoxib group had signally higher Lysholm scores compared with the diclofenac sodium group ( P < 0.05 ). The iguratimod group got markedly lower Western Ontario and McMaster Universities (WOMAC) score compared with the celecoxib group ( P < 0.05 ); Compared with the diclofenac sodium group, the celecoxib group got remarkably lower WOMAC score ( P < 0.05 ). During treatment, few patients suffered from mild gastrointestinal discomfort and hepatic dysfunction in the three groups, and no other severe adverse reactions were found. No statistical difference in the total incidence of adverse reactions among the three groups was observed ( P > 0.05 ). Conclusion. The combination of nonsteroidal anti-inflammatory drugs with platelet-rich plasma can further reduce the inflammatory reactions of the patients with osteoarthritis and improve their knee joint function. Significantly, the iguratimod, with high safety, has observably better effects on inhibiting inflammatory factors and improving knee joint function compared with diclofenac sodium and celecoxib.

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Section: Discussionsupporting

confidence: 92%

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Jiang

Zhang

Huang³

et al. 2022

Journal of Healthcare Engineering

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“…Chunxue Pu studied the effects of early and late use of celecoxib on the postoperative efficacy, safety, and postoperative satisfaction of patients with hip osteoarthritis undergoing total hip arthroplasty. Their study found that patients in the pre-treatment group who started using celecoxib before THA had better satisfaction than those in the post-treatment group who started using celecoxib after THA ( 9 ).…”

Section: Resultsmentioning

confidence: 99%

Patient satisfaction after total hip arthroplasty: Influencing factors

Shao

2023

Front. Surg.

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It is reported that the dissatisfaction rate after primary total hip arthroplasty (THA) is between 7% and 20%. Patient satisfaction has already become a public health problem that puzzles the world, and it is a problem to be solved that cannot be ignored in the development of global public health. The purpose of this paper is to conduct a narrative review of the literature to answer the following questions: what are the main factors leading to high patient satisfaction or dissatisfaction after THA? The literature on patient satisfaction after THA was reviewed. As far as we know, there is no such detailed and timely overview of THA satisfaction as this article, and the purpose articles we use search engines to search are all RCT (Randomized Controlled Trial) type works, excluding cross-sectional studies and other experiments with low evidence level. Hence, the quality of this article is high. The search engines used are MEDLINE (PubMed) and EMBASE. The keywords used are “THA” and “satisfaction.” The main preoperative, perioperative, and postoperative factors that affect patient satisfaction are summarized in detail below.

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Efficacy and safety between early use and late use of celecoxib in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study

Cited by 2 publications

References 15 publications

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Patient satisfaction after total hip arthroplasty: Influencing factors

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