Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin

Fazzio, Luis Emilio; Streitenberger, Nicolás; Galván, Walter Rubén; Sánchez, Ricardo Ortíz; Gimeno, Eduardo Juan; Sanabria, Rodrigo Eduardo Fabrizio

doi:10.1016/j.vetpar.2016.04.003

Cited by 13 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even though MOX acts on the same receptor as IVM, cross-resistance is not certain. To date resistance to IVM is much more widespread than to MOX in various nematodes [ 29 ], and MOX is still more effective than IVM against IVM-resistant parasites [ 64 ]. Thirdly, no adverse events occurred in response to MOX treatment, in line with other studies indicating that MOX may be less toxic than IVM because MOX is a poorer substrate for P-glycoproteins than IVM [ 29 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

et al. 2016

View full text Add to dashboard Cite

BackgroundScabies is one of the commonest dermatological conditions globally; however it is a largely underexplored and truly neglected infectious disease. Foremost, improvement in the management of this public health burden is imperative. Current treatments with topical agents and/or oral ivermectin (IVM) are insufficient and drug resistance is emerging. Moxidectin (MOX), with more advantageous pharmacological profiles may be a promising alternative.Methodology/Principal FindingsUsing a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0.3 mg/kg once), IVM (0.2 mg/kg twice) or no treatment. We evaluated treatment efficacies by assessing mite count, clinical lesions, pruritus and ELISA-determined anti-S. scabiei IgG antibodies reductions. Plasma and skin pharmacokinetic profiles were determined. At day 14 post-treatment, all four MOX-treated but only two IVM-treated pigs were mite-free. MOX efficacy was 100% and remained unchanged until study-end (D47), compared to 62% (range 26–100%) for IVM, with one IVM-treated pig remaining infected until D47. Clinical scabies lesions, pruritus and anti-S. scabiei IgG antibodies had completely disappeared in all MOX-treated but only 75% of IVM-treated pigs. MOX persisted ~9 times longer than IVM in plasma and skin, thereby covering the mite’s entire life cycle and enabling long-lasting efficacy.Conclusions/SignificanceOur data demonstrate that oral single-dose MOX was more effective than two consecutive IVM-doses, supporting MOX as potential therapeutic approach for scabies.

show abstract

Section: Discussionmentioning

confidence: 99%

Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Notable (not exhaustive) examples of the relative efficacy of MOX in these situations include H. contortus in lambs (Lloberas et al, 2015), O. ostertagi in cattle in New Zealand (Waghorn et al, 2016), Haemonchus and Cooperia spp. in feedlot calves in Argentina (Fazzio et al, 2016), C. onchophora in cattle in Scotland (Bartley et al, 2012) and trichostrongyloid nematodes in Brazil (Lopes et al, 2014). In these field studies, although MOX performed better than avermectins, a level of resistance to MOX (e.g., efficacies between 80 and 90%) was nevertheless evident.…”

Section: Resistance To Macrocyclic Lactonesmentioning

confidence: 99%

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

Prichard

Geary

2019

International Journal for Parasitology: Drugs and Drug Resistan

108

View full text Add to dashboard Cite

Macrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to MLs is of increasing concern. Resistance is commonplace throughout the world in nematode parasites of small ruminants and is of increasing concern in horses, cattle, dogs and other animals. It is suspected in Onchocerca volvulus in humans. In most animals, resistance first arose to the avermectins, such as ivermectin (IVM), and subsequently to moxidectin (MOX). Usually when parasite populations are ML-resistant, MOX is more effective than avermectins. MOX may have higher intrinsic potency against some parasites, especially filarial nematodes, than the avermectins. However, it clearly has a significantly different pharmacokinetic profile. It is highly distributed to lipid tissues, less likely to be removed by ABC efflux transporters, is poorly metabolized and has a long half-life. This results in effective concentrations persisting for longer in target hosts. It also has a high safety index. Limited data suggest that anthelmintic resistance may be overcome, at least temporarily, if a high concentration can be maintained at the site of the parasites for a prolonged period of time. Because of the properties of MOX, there are reasonable prospects that strains of parasites that are resistant to avermectins at currently recommended doses will be controlled by MOX if it can be administered at sufficiently high doses and in formulations that enhance its persistence in the host. This review examines the properties of MOX that support this contention and compares them with the properties of other MLs. The case for using MOX to better control ML-resistant parasites is summarised and some outstanding research questions are presented.

show abstract

“…Trichostrongylus axei parasita o abomaso e causa hemorragia, perda de proteína para o lúmen intestinal e encurtamento das vilosidades intestinais. Fazzio et al, (2016) relataram que as alterações gástricas se assemelham a Ostertagia spp., alterando pH e aumentando a permeabilidade na mucosa. Já a espécie T. colubriformis acomete a porção anterior do intestino delgado (Monteiro, 2014).…”

Section: Trichostrongylus Sppunclassified

“…Relata-se atualmente, uma queda em sua eficiência contra o gênero Trichuris spp. (Fazzio et al, 2016).…”

Section: Imidazotiazóis E Tetrahidropirimidinasunclassified

Diagnóstico e controle químico das helmintoses em bovinos: revisão de literatura

Almeida

Chagas

Ávila

et al. 2020

RSD

View full text Add to dashboard Cite

A bovinocultura tem uma atividade crescente em todo o Brasil, no entanto, a produção desses ruminantes é prejudicada pelas helmintoses, por causarem retardo no desenvolvimento dos animais, levando à baixa produtividade e, consequentemente, elevadas perdas econômicas. O controle do parasitismo por nematóides gastrintestinais é realizado principalmente com o uso de anti-helmínticos. A utilização intensiva desses medicamentos, uso de subdoses, diagnósticos incorretos e a falta de rotatividade de bases farmacológicas têm provocado um sério problema sanitário: a resistência dos helmintos aos fármacos. O teste OPG é uma ferramenta útil, prática, rápida e que não requer o sacrifício dos animais, muito utilizado para diagnóstico da doença e prescrição do tratamento correto. O presente estudo visa apresentar o diagnóstico e controle químico das principais helmintoses bovinas perante a literatura, com o objetivo de contribuir para o melhor desenvolvimento dos bezerros, boa produtividade e ganho econômico satisfatório do produtor.

show abstract

Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin

Cited by 13 publications

References 19 publications

Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

Diagnóstico e controle químico das helmintoses em bovinos: revisão de literatura

Contact Info

Product

Resources

About