Efficacy and pregnancy outcomes of focused ultrasound for cervical high-grade squamous intraepithelial lesions

Yao, Yuqin; Wang, Wenping; Liu, Yujuan; Yong, Min; Zhang, Miao; Yang, Yulu; Xu, Gan; Qu, Dacheng; Zhou, Honggui

doi:10.1080/02656736.2023.2250936

Cited by 1 publication

(1 citation statement)

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“…Several studies have shown that treatment with ablation has no significant adverse effects on pregnancy outcomes, including preterm birth and PROM. 22 , 23 Although it is important to protect fertility, reducing the persistence or recurrence of precancerous lesions is equally important. Some research suggests that persistence of HPV infection and positive endocervical margins are risk factors for the persistence or recurrence of CIN, and there is no significant association with the type of therapy.…”

Section: Discussionmentioning

confidence: 99%

Differential Analysis of Pregnancy Outcomes After Treatment of HIFU and LEEP in Patients with Cervical High-Grade Squamous Intraepithelial Lesions

Shen,

Li,

et al. 2024

IJWH

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Purpose To verify whether there is lower incidence of adverse pregnancy outcomes after high-intensity focused ultrasound (HIFU) treatment than loop electrosurgical excision procedure (LEEP) in young women of childbearing age. Patients and Methods This retrospective cohort study enrolled 46 patients treated with HIFU and 46 patients treated with LEEP. To compare the differences between the two groups, Fisher’s exact test or the Kruskal–Wallis (K-W/H) test was used in the univariate analysis, while the logistic regression method was applied for further verification. Results Basic characteristics showed no differences between the two groups (P > 0.05) except for parity (P < 0.001). Preterm birth rates were 6.52% and 0.00% in patients with cervical high-grade squamous intraepithelial lesions (HSIL) treated with LEEP and HIFU, respectively. The incidence rates of premature rupture of membranes (PROM) were respectively 15.22% and 21.74% in the two groups. There was no significant difference in pregnancy outcomes between the two groups (P > 0.05). Conclusion This study is the first to compare the pregnancy outcomes of patients with cervical HSIL who treated with LEEP and HIFU procedures. Both HIFU treatment and LEEP are available options for patients of reproductive age with cervical HSIL. Therefore, it is necessary to conduct prospective single-center or multicenter randomized controlled studies.

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Section: Discussionmentioning

confidence: 99%