Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model

Jacobs, S.; Simhaee, David A.; Marsano, Anna; Fomovsky, Gregory M.; Niedt, George W.; Wu, June K.

doi:10.1016/j.bjps.2008.03.024

Cited by 100 publications

(91 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another factor influencing faster healing, especially the reduction of the size of the wound is the experimentally proven increased production of collagen and the filling of the tissue defect (6). Clinical observations of leg wound healing confirmed the above-mentioned, where in case of hypobaric therapy one observed a significantly faster reduction in the size of the wound, as compared to patients subject to traditional therapy (7)(8)(9).…”

supporting

confidence: 71%

“…Changes which take place in the capillaries connected with the increase in their diameter and volume, also increase blood flow and facilitate the migration of inflammatory cells (especially macrophages and granulocytes) towards the lumen of the wound, which has been proved by means of experimental studies (5). The activation of factors stimulating angiogenesis has also been demonstrated, both in experimental (6) and clinical studies (3).…”

mentioning

confidence: 92%

See 1 more Smart Citation

Negative Pressure therapy in the treatment of wounds - review of literature data and multicenter experience

Banasiewicz¹,

Malinger²,

Zieliński³

et al. 2010

Polish Journal of Surgery

View full text Add to dashboard Cite

supporting

confidence: 71%

mentioning

confidence: 92%

Negative Pressure therapy in the treatment of wounds - review of literature data and multicenter experience

Banasiewicz¹,

Malinger²,

Zieliński³

et al. 2010

Polish Journal of Surgery

View full text Add to dashboard Cite

“…22 Negative pressure wound therapy supports wound healing by decreasing the bioburden and increasing wound closure rates. 23,24 The use of wound vacuum devices has been evaluated in the trauma literature, and negative pressure therapy has been found to promote the formation of granulation tissue in addition to decreasing wound closure time. 25 Animal studies performed by the manufacturer KCI Ò have compared negative pressure therapy using silver-impregnated sponges and nonimpregnated sponges.…”

Section: Discussionmentioning

confidence: 99%

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

LaRiviere

Goldin

Avansino

2011

The Journal of the American College of Certified Wound Speciali

View full text Add to dashboard Cite

Silver-containing topical agents are used to help prevent infectious complications in wound therapy. Toxicity from topical silver agent exposure was initially reported in 1975 and was clinically characterized by granulocytopenia. Currently, the data regarding potential toxicity associated with silver-impregnated devices are limited. A 23-year-old patient receiving chemotherapy for acute lymphoblastic leukemia presented with necrotizing fasciitis of the abdominal wall and scrotum from a Crohn disease-related psoas-enteric fistula. Surgical debridement of the soft-tissue and abdominal musculature was performed to the peritoneum. Silver-containing foam sponges and wound vacuumassisted closure were applied directly to the peritoneum 2 weeks after initial debridement. Subsequently, the patient developed leukopenia, and workup revealed the serum silver level was 4 times normal level. Silver-impregnated sponges were discontinued and silver-free sponges and wound vacuum-assisted closure therapy resumed, followed by leukopenia resolution. Silver toxicity associated with routine application of silver-impregnated sponges has not been previously reported.

show abstract

“…• Mechanotransduction (resultant positive chemical activity from mechanical stimuli) and stretch increased the growth rate and migration of fibroblasts 26 • increased collagen organization 34 • Increased expression of fibroblast growth factor 2 (FGF-2) 34 • increased expression of vascular endothelial growth factor (veGF) There was a 1.57% per day wound healing in the patient treated in hospital compared with 1.59% per day in patients treated with the portable device; however, this was not statistically significant. Treatment of these wounds at home negated the costs of hospital stay, freeing up hospital beds.…”

Section: Direct Effectsmentioning

confidence: 99%

Using portable negative pressure wound therapy devices in the home care setting

Burke¹,

Morley²,

Khanbhai³

2014

SHTT

View full text Add to dashboard Cite

Negative pressure wound therapy (NPWT) is the continuous or intermittent application of subatmospheric pressure to the surface of a wound that improves the wound environment, accelerates healing, and reduces wound closure time. Since its first documented use, this technology has lent itself to a number of adaptations, most notably, the development of portable devices facilitating treatment in the home care setting. With advancing surgical standards, wound healing is an important rate-limiting factor in early patient discharge and often a major cost of inpatient treatment. The efficacy of NPWT in the home care setting has been investigated through rate of wound closure, time in care, and patient experience. Rate of wound closure is the most appropriate primary end point. Much can be gleaned from patient experience, but the future success of portable NPWT will be measured on time in care and therefore cost effectiveness. However, there is a lack of level 1a evidence demonstrating increased efficacy of portable over inpatient NPWT. The development of portable NPWT is an encouraging innovation in wound care technology, and extending the benefits to the home care setting is both possible and potentially more beneficial.

show abstract

Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model

Cited by 100 publications

References 19 publications

Negative Pressure therapy in the treatment of wounds - review of literature data and multicenter experience

Negative Pressure therapy in the treatment of wounds - review of literature data and multicenter experience

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

Using portable negative pressure wound therapy devices in the home care setting

Contact Info

Product

Resources

About