Efficacy and mechanisms of dietary polyphenols in mitigating rheumatoid arthritis

Christman, Lindsey M.; Gu, Liwei

doi:10.1016/j.jff.2020.104003

Cited by 23 publications

(12 citation statements)

References 68 publications

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“…Further, depending on their metabolism and bioavailability in humans, beneficial or less beneficial effects of the secondary metabolites from plants are expected in the case of digestive processes, as well as systemically. The most likely side effects are expected in the case of plant-based products used for handling chronic conditions, such as those related to chronic inflammation (e.g., arthritis and inflammatory bowel diseases) [8][9][10] and metabolic diseases (e.g., diabetes and obesity) [11][12][13], that are essentially based on antioxidant and anti-inflammatory compounds (polyphenols and other active classes) to reduce the inflammation process and sugar absorption in humans. Their potential, harmful effects could primarily occur due to the inhibitory activity upon the digestive enzymes, leading to the incomplete digestion of carbohydrates, proteins and lipids, which, further, could cause the initiation or deepening of food intolerance, irritable bowel syndrome and other bowel diseases.…”

Section: Introductionmentioning

confidence: 99%

In Silico Study Approach on a Series of 50 Polyphenolic Compounds in Plants; A Comparison on the Bioavailability and Bioactivity Data

Stefaniu

Pîrvu

2022

Molecules

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Fifty (50) phytocompounds from several subclasses of polyphenols, chosen based on their abundance in the plant world, were analyzed through density functional methods, using computational tools to evaluate their oral availability and particular bioactivity on several cell modulators; key descriptors and molecular features related to the electron density and electrostatic potential for the lowest energy conformers of the investigated molecules were computed. An analysis of the bioactivity scores towards six cell modulators (GPCR ligand, ion channel modulator, kinase inhibitor, nuclear receptor ligand, protease inhibitor and enzyme inhibitor) was also achieved, in the context of investigating their potential side effects on the human digestive processes. Summarizing, computational results confirmed in vivo and in vitro data regarding the high bioavailability of soy isoflavones and better bioavailability of free aglycones in comparison with their esterified and glycosylated forms. However, by a computational approach analyzing Lipinski’s rule, apigenin and apigenin-7-O-rhamnoside, naringenin, hesperetin, genistein, daidzin, biochanin A and formonetin in the flavonoid series and all hydroxycinnamic acids and all hydroxybenzoic acids excepting ellagic acid were proved to have the best bioavailability data; rhamnoside derivatives, the predominant glycosides in green plants, which were reported to have the lowest bioavailability values by in vivo studies, were revealed to have the best bioavailability data among the studied flavonoids in the computational approach. Results of in silico screening on the phenolic derivatives series also revealed their real inhibitory potency on the six parameters studied, showing a remarkable similitude between the flavonoid series, while flavonoids were more powerful natural cell modulators than the phenyl carboxylic acids tested. Thus, it can be concluded that there is a need for supplementation with digestive enzymes, mainly in the case of individuals with low digestive efficiency, to obtain the best health benefits of polyphenols in humans.

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Section: Introductionmentioning

confidence: 99%

In Silico Study Approach on a Series of 50 Polyphenolic Compounds in Plants; A Comparison on the Bioavailability and Bioactivity Data

Stefaniu

Pîrvu

2022

Molecules

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“…To this end, the SSE was first screened at various extraction conditions to find the optimal preparation with the highest total phenolic content. Phenolic compounds, one of the most diverse groups of plant secondary metabolites, ranging from phenols, flavonoids, to lignins, tannins, and cutins, have been demonstrated to help control the RA condition due to powerful anti-inflammatory properties (Christman & Gu 2020 ; Behl et al. 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment

et al. 2022

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Purpose Rheumatoid arthritis, a chronic and progressive inflammation condition in the joints, has significantly reduced the patient quality of life and life expectancy. Crucially, there is no complete therapy for this disease, and the current treatments possess numerous side effects. Thus, novel therapeutic approach is necessary. To that end, this study developed novel silk fibroin in-situ hydrogel containing Sesbania sesban L. extract, a plant with high anti-inflammatory actions that are beneficial for rheumatoid arthritis treatments. Methods The hydrogels were manufactured using simple method of spontaneous gelation at different temperature. The gel properties of morphology, gelation time, viscosity, gel strength, stability, drug loading capacity, drug release rate, and in-vitro anti-inflammatory activity were investigated with appropriate methods. Results The optimal formulation had highly porous structure, with a gelation time of 0.5 h at room temperature and bodily temperature of 37 °C, a viscosity of 2530 ± 50 cP, a gel strength of 1880.14 ± 35.10 g, and a physical stability of >6 months. Moreover, the hydrogel contained the Sesbania sesban L. leaf extract with a total phenolic content of 92.8 ± 8.30 mg GAE/g, and sustained the release rate for >20 dạys, followed the Higuchi model. Regarding the in-vitro activities, all formulations were nontoxic to the RAW 264.7 cell line and demonstrated comparable anti-inflammatory activity to the free extract, in terms of the NO reduction levels. Conclusion Conclusively, the systems possessed potential properties to be further investigated to become a prospective rheumatoid arthritis treatment.

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“…Previous studies have found that polyphenolic compounds have been reported to have significant anti-inflammatory effects. [52][53][54] In general, the anti-inflammatory effects of the cream were stronger than those of the supernatant. We speculated that the relative high content of the polyphenols played an important role in the anti-inflammatory effect of the cream.…”

Section: Anti-inflammatory Activities Of the Supernatant And The Creammentioning

confidence: 99%

Comparison of the chemical composition and antioxidant, anti-inflammatory, α-amylase and α-glycosidase inhibitory activities of the supernatant and cream from black tea infusion

Qin

Lian

et al. 2022

Food Funct.

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Efficacy and mechanisms of dietary polyphenols in mitigating rheumatoid arthritis

Cited by 23 publications

References 68 publications

In Silico Study Approach on a Series of 50 Polyphenolic Compounds in Plants; A Comparison on the Bioavailability and Bioactivity Data

In Silico Study Approach on a Series of 50 Polyphenolic Compounds in Plants; A Comparison on the Bioavailability and Bioactivity Data

Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment

Comparison of the chemical composition and antioxidant, anti-inflammatory, α-amylase and α-glycosidase inhibitory activities of the supernatant and cream from black tea infusion

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