Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF

Lai, Ziyan; Zhang, Qingping; Liang, Lan; Wei, Yichen; Duan, Gaoxiong; Mai, Weiyi; Zhao, Lihua; Liu, Peng; Deng, Demao

doi:10.3389/fnmol.2022.852882

Cited by 12 publications

(10 citation statements)

References 56 publications

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“…EA can reduce oxidative stress and anti-apoptotic cell death by increasing superoxide dismutase activity in the brain (Wang et al, 2011 ). MB can inhibit apoptosis and oxidative stress and improve vascular endothelial growth factor inflammation (Lai et al, 2022 ). MB may improve cognitive function in VaD patients by inhibiting hippocampal neuronal apoptosis (Yang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies

et al. 2022

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IntroductionThe second most prevalent cause of dementia is vascular dementia (VaD). Furthermore, acupuncture is a relatively safe and effective traditional therapy for individuals with VaD. We performed a network meta-analysis to assess the effectiveness and safety of various acupuncture therapies for VaD based on existing research.MethodsWe searched six electronic databases to screen for randomized controlled trials (RCTs) comparing different acupuncture treatments in VaD patients. The Cochrne tool (Review Manager 5.3) was used to evaluate the risk of bias of the included RCTs. Based on the Grading of Recommendations Assessment, Development and Evaluation framework, we assessed the confidence in the evidence using the Confidence In the results from Network Meta-Analysis approach. We used the frequency approach to perform the network meta-analysis. Data were analyzed using R 4.1.1.ResultsIn total, we included 46 eligible studies. The results of the network analysis showed that the combined interventions of moxibustion (MB) with body acupuncture (BA) (MB + BA) and electroacupuncture (EA) with scalp acupuncture (SA) with BA (EA + SA + BA) were more effective in improving cognitive functions and activities of daily living compared with SA or BA alone. However, in the subgroup analysis, EA + SA + BA showed better efficacy in short- and mid-term acupuncture compared with other acupuncture therapies.ConclusionCombined acupuncture therapy may be a safe and effective intervention for individuals with VaD, and MB + BA and EA + SA + BA appear to be the most effective interventions. However, because the analysis of this study was based on low-to-moderate evidence, there remains no strong supporting evidence. Thus, high-quality, large-scale, and long-term studies should be conducted in the future to assess the effectiveness and safety of acupuncture in VaD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022354573.

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Section: Discussionmentioning

confidence: 99%

A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies

et al. 2022

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“…Cerebral blood flow (rCBF) in the left lateral orbital gyrus was decreased in the dizzy MCI group compared with the non-dizzy MCI group (Na et al, 2020). In an ALFF-based fMRI study, researchers found significantly increased ALFF values in the right lingual gyrus of MCI patients compared with HC (Lai et al, 2022). Occipital gray matter volume correlates with neuropsychological performance in patients with amnestic MCI or mild AD (Arlt et al, 2013).…”

Section: Key Regions Of Interests and Genes Selectionmentioning

confidence: 99%

“…This method used multi-task learning and parameter decomposition to simultaneously identify patternconsistent and pattern-specific brain regions and SNP loci. Furthermore, they proposed a parametric decomposition-based sparse multi-view canonical correlation analysis (PDSMCCA) method to identify modality-sharing and specific information from multimodal data to gain insight into the complex pathology of brain diseases (Zhang et al, 2022). However, the above two algorithms only supported the analysis of multimodal brain imaging and single-modal genetic data.…”

Section: Introductionmentioning

confidence: 99%

Associating brain imaging phenotypes and genetic risk factors via a hypergraph based netNMF method

Zhuang

Tian²,

Xiong³

et al. 2023

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. Mild cognitive impairment (MCI) is an early disease that may progress to AD. The effective diagnosis of AD and MCI in the early stage has important clinical significance.MethodsTo this end, this paper proposed a hypergraph-based netNMF (HG-netNMF) algorithm for integrating structural magnetic resonance imaging (sMRI) of AD and MCI with corresponding gene expression profiles.ResultsHypergraph regularization assumes that regions of interest (ROIs) and genes were located on a non-linear low-dimensional manifold and can capture the inherent prevalence of two modalities of data and mined high-order correlation features of the two data. Further, this paper used the HG-netNMF algorithm to construct a brain structure connection network and a protein interaction network (PPI) with potential role relationships, mine the risk (ROI) and key genes of both, and conduct a series of bioinformatics analyses.ConclusionFinally, this paper used the risk ROI and key genes of the AD and MCI groups to construct diagnostic models. The AUC of the AD group and MCI group were 0.8 and 0.797, respectively.

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“…Moxibustion and acupuncture are important means of treating AD in traditional Chinese medicine ( Cao et al, 2016 ; Rigun et al, 2021 ). Although the beneficial effects of moxibustion and acupuncture for AD have been primarily studied both preclinically and clinically ( Zhou et al, 2014 ; Xie et al, 2021 ; Huang et al, 2022 ; Lai et al, 2022 ; Zhang et al, 2022 ), the real efficacy of these treatments on AD remains inconclusive, and the underlying mechanisms are largely unexplored. It has been shown that moxibustion can increase the flow velocity of cerebrospinal fluid and increase the expression of AQP4 in the cortex of mice ( Chen et al, 2021 ), but it is uncertain whether moxibustion can induce the polarity or dynamical localization of AQP4.…”

Section: Introductionmentioning

confidence: 99%

Moxibustion improves hypothalamus Aqp4 polarization in APP/PS1 mice: Evidence from spatial transcriptomics

Liu

Li²,

Shen³

et al. 2023

Front. Aging Neurosci.

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Aquaporin-4 (AQP4) is highly polarized to perivascular astrocytic endfeet. Loss of AQP4 polarization is associated with many diseases. In Alzheimer’s disease (AD), AQP4 loses its normal location and thus reduces the clearance of amyloid-β plaques and tau protein. Clinical and experimental studies showed that moxibustion can improve the learning and memory abilities of AD. To explore whether moxibustion can affect the polarization of AQP4 around the blood-brain barrier (BBB), we used spatial transcriptomics (ST) to analyze the expression and polarization of Aqp4 in wild-type mice, APP/PS1 mice, and APP/PS1 mice intervened by moxibustion. The results showed that moxibustion improved the loss of abnormal polarization of AQP4 in APP/PS1 mice, especially in the hypothalamic BBB. Besides, the other 31 genes with Aqp4 as the core have similar depolarization in APP/PS1 mice, most of which are also membrane proteins. The majority of them have been reversed by moxibustion. At the same time, we employed the cerebrospinal fluid circulation gene set, which was found to be at a higher level in the group of APP/PS1 mice with moxibustion treatment. Finally, to further explore its mechanism, we analyzed the mitochondrial respiratory chain complex enzymes closely related to energy metabolism and found that moxibustion can significantly increase the expression of mitochondrial respiratory chain enzymes such as Cox6a2 in the hypothalamus, which could provide energy for mRNA transport. Our research shows that increasing the polarization of hypothalamic Aqp4 through mitochondrial energy supply may be an important target for moxibustion to improve cognitive impairment in APP/PS1 mice.

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Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF

Cited by 12 publications

References 56 publications

A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies

A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies

Associating brain imaging phenotypes and genetic risk factors via a hypergraph based netNMF method

Moxibustion improves hypothalamus Aqp4 polarization in APP/PS1 mice: Evidence from spatial transcriptomics

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