Efficacy and Long-Term Clinical Outcome of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder After Electroconvulsive Therapy

Ahmadi, Naser; Moss, Lori; Simon, Edwin; Nemeroff, Charles B.; Atre-Vaidya, Nutan

doi:10.1002/da.22451

Cited by 42 publications

(40 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, we note that results of a recent study of ECT in veterans with MDD and PTSD showed a positive effect on both MDD and PTSD symptoms. 21 Thus, the effects of rTMS and ECT appear to be quite different in this population of veterans.…”

Section: Possible Causes Of High Remission Ratesmentioning

confidence: 86%

Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Possible Causes Of High Remission Ratesmentioning

confidence: 86%

Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The copyright holder for this preprint this version posted October 13, 2020. ; https://doi.org/10.1101/2020.10.10.20210450 doi: medRxiv preprint effective in those with depression and comorbid PTSD compared with depression only (34), and may be superior to pharmacotherapy only (35). Further research on ECT for PTSD is warranted.…”

Section: Discussionmentioning

confidence: 99%

Electroconvulsive Therapy with a Memory Reactivation Intervention for Post-Traumatic Stress Disorder: A Randomized Controlled Trial

Tang

Trought

Gicas

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects. We sought to exploit this phenomenon as a potential treatment for PTSD with a clinical trial of patients with PTSD receiving ECT. Methods Patients with severe depression with comorbid PTSD referred for ECT treatment were randomly assigned to reactivation of a traumatic or non-traumatic memory using script driven imagery prior to each ECT treatment. Primary outcomes were change in scores on the Modified PTSD Symptom Scale - Self Report (MPSS-SR) and the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). Assessments were completed by blinded raters. Secondary outcomes included a comparison of the change in heart rate (HR) while listening to the script. Results Twenty-eight participants were randomized, and 25 patients who completed a post-ECT assessment were included in the analysis. No significant group differences were found in the MPSS-SR or CAPS-5 scores from pre-ECT to post-ECT or 3-month follow-ups. However, both groups improved at post-ECT and 3-month follow up. Partial eta squared estimates of effect size showed large effect sizes for all outcomes (η2 > 0.13). Changes in HR were not significantly different between groups or over time. Conclusions In this RCT, ECT paired with pre-treatment traumatic memory reactivation was not more effective for treating PTSD symptoms than ECT alone. While our primary hypothesis was not supported, our data provides further support for the efficacy of ECT for improving symptoms of PTSD with comorbid depression.

show abstract

“…The application of ECT is associated with lower overall mortality, as compared with depressed patients receiving psychotropics alone, or no treatment [15]. This has been replicated again in a study by Ahmadi, et al [16], with a mean duration of eight years showing statistically significant risk reduction for all-cause mortality as well as lower mortality due suicide and lower cardiovascular mortality in the ECT group compared to patients who did not receive ECT.…”

Section: Introductionmentioning

confidence: 86%

Is Conduct of Research in Electroconvulsive Therapy Ethical?

Youssef

McCall

2016

J Psy Neuro Dis Brain Stim

View full text Add to dashboard Cite

Introduction Controversy surrounding ECT creates skepticism about the ethics of conducting ECT research. This paper discusses the ethical conduct of clinical research and then focus on the ethics as applied to ECT. Methods PubMed was searched for articles related to the ethical conduct of research and that of ECT research published in English. Results ECT research is ethically justified and should always continue to be conducted with the highest ethical standards. ECT research entails few ethical peculiarities such as involving multiple sessions were capacity to consent can change. It would be unethical not to conduct ECT research. Conclusion ECT research must be based on sound hypotheses in the presence of a clinical equipoise in well-designed studies. ECT studies must select a fair and non-biased sample of participants. It is important that participants represent the broad population of the people that would be receiving ECT for that specific indication. ECT research is ethical; and more research in this field could help decrease stigma and barriers to treatment, and/or reduce side effects and improve efficacy of a potentially life-saving intervention.

show abstract

Efficacy and Long-Term Clinical Outcome of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder After Electroconvulsive Therapy

Abstract: ECT is associated with a significant reduction of symptoms of PTSD and MDD, as well as reduction in risk of suicidality, cardiovascular, and all-cause mortality in MDD and PTSD, an effect more robust than antidepressant-therapy alone.

Cited by 42 publications

References 33 publications

Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

Electroconvulsive Therapy with a Memory Reactivation Intervention for Post-Traumatic Stress Disorder: A Randomized Controlled Trial

Is Conduct of Research in Electroconvulsive Therapy Ethical?

Contact Info

Product

Resources

About