Efficacy and dermal tolerance of a novel alcohol‐based skin antiseptic in horses

Tannahill, Victoria J.; Cogan, Tristan A; Allen, Kate J; Acutt, Elizabeth V.; Busschers, Evita

doi:10.1111/vsu.12793

Cited by 6 publications

(26 citation statements)

References 16 publications

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“…That previous study differed from the current experiment in 2 ways. Remanence of the antiseptic effect was not assessed, and the alcohol‐based skin antiseptic used in that study was intended for skin antisepsis in human patients and not as a specific HA hand rub for a surgeon's hands . The alcohol‐based product also contained propan‐2‐ol and benzalkonium chloride.…”

Section: Discussionmentioning

confidence: 99%

“…They also recommend the use of alcoholic antiseptic solutions that are based on chlorhexidine gluconate (CHXG) for surgical site skin preparation in patients undergoing a surgical procedure . In veterinary medicine, povidone‐iodine (PI) or CHX is generally used for skin antisepsis . Mechanical scrubbing of the skin for 5 minutes with CHXG followed by either a saline rinse or an alcohol rinse is one of the standard, commonly used methods of skin antisepsis for evaluating the efficacy of other protocols …”

Section: Introductionmentioning

confidence: 99%

“…In veterinary medicine, povidone‐iodine (PI) or CHX is generally used for skin antisepsis . Mechanical scrubbing of the skin for 5 minutes with CHXG followed by either a saline rinse or an alcohol rinse is one of the standard, commonly used methods of skin antisepsis for evaluating the efficacy of other protocols …”

Section: Introductionmentioning

confidence: 99%

“…Recent articles in both human and veterinary medicine have reported that HA solutions are more efficient than traditional medicated soaps for the presurgical hand antisepsis of surgeons . Even though alcohol‐based hand rubs have been demonstrated to be superior to currently available surgical scrubs, their use in surgical site skin preparation has thus far been assessed only in horses …”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] In veterinary medicine, povidoneiodine (PI) or CHX is generally used for skin antisepsis. [9][10][11][12] Mechanical scrubbing of the skin for 5 minutes with CHXG followed by either a saline rinse 10 or an alcohol rinse 12 is one of the standard, commonly used methods of skin antisepsis for evaluating the efficacy of other protocols. 10,12 To preserve the efficacy of antiseptic agents in controlling infections, it is essential to prevent the emergence of bacteria resistant to these compounds as well as cross resistance by using these antimicrobial compounds in an appropriate manner.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs

et al. 2019

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Objective To compare preparation time, ease of application, and elimination of skin contamination of 3 skin preparation methods for asepsis. Study design Experimental study. Animals Healthy dogs (n = 6) with no clinical signs of skin disease. Methods Three sites on each dog were randomly allocated to 1 of 3 preparation protocols for asepsis: (1) 5 scrubbings with chlorhexidine gluconate and rinsing (CHXG), (2) washing with mild soap prior to 3 rubbings with hydroalcoholic solution (soap‐HAR), or (3) 3 rubbings with hydroalcoholic solution (HAR). The duration of each method of skin preparation was recorded. A Count‐Tact agar plate was placed in the center of each site before, immediately after, 1 hour after, and 3 hours after antiseptic application. Plates were cultured, and colony forming units (CFU) were counted. Results Skin preparation lasted an average of 375 seconds for CHXG, 240 seconds for soap‐HAR, and 190 seconds for HAR (P = .00049). Nine CFU (median) were cultured from the skin prior to preparation, with no difference between sites on any animal or for any method. Colony forming units were not detected at any time on any site in any dog after antiseptic application. Conclusion Rubbing with hydroalcoholic (HA) solution was as effective as CHXG and prevented bacterial growth for at least 3 hours under these experimental conditions. Rubbing with hydroalcoholic solution was also faster and easier to perform. Clinical significance Because there is currently no known resistance to HA solution, preparation of the surgical site with HAR should be considered to prevent the emergence of bacterial resistance to chlorhexidine as well as potential cross‐resistances to antibiotics. Transfer to clinical animals requires additional investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs

et al. 2019

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Equine Skin Antisepsis Using an Alcohol-Based Rub

Doyle

Saab

Lewis

et al. 2019

Journal of Equine Veterinary Science

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Comparison of chlorhexidine and alcohol‐based antisepsis of the distal limbs of horses

Doyle

Saab

Lewis

et al. 2021

Equine Veterinary Journal

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Background: An alcohol-based rub has been confirmed effective at reducing bacterial counts on equine skin. Skin sites with expected high bacterial burden have not been tested or has a comparison to a common protocol been performed. Objectives:To determine if ethanol-based antisepsis reduces bacterial counts on the equine distal limb comparable to a current chlorhexidine scrub method and determine the most effective application technique for the product. Study design: Randomised trial.Methods: Forty-one horses were used in the study. By horse, each limb was randomly assigned to a treatment group: 5min scrub using 4% chlorhexidine gluconate to a clipped site (CHG); 90s scrub using 80% ethanol to a clipped site (ETC); 90s contact with 80% ethanol applied as a spray to a clipped site (ETS) and 90s scrub using 80% ethanol to an unclipped site (ETUC). Samples were collected pre-and post-treatment and plated in duplicate. Bacterial counts were log 10 transformed and averaged between duplicates. A linear mixed model was used to compare mean log 10 CFU/mL reduction between groups. A cost-benefit analysis was performed.Results: There was no significant difference in mean log 10 CFU/mL reduction between CHG and ETC in either fore-or hindlimbs. In forelimbs, there was no significant difference in mean log 10 CFU/mL reduction between any groups. In hindlimbs, CHG had significantly greater mean log 10 CFU/mL reduction than ETUC and ETS. No significant difference in cost-benefit was found between CHG and ETC. Significant differences were noted between CHG and both ETUC and ETS.Main limitations: Researchers were not blinded to treatment group during sample collection. Conclusions:This study showed no significant difference in reduction in bacterial counts on the distal limb of horses between CHG and ethonol (ET) when applied as a scrub to a clipped site and there was no significant difference in cost-benefit between these treatments.

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Efficacy and dermal tolerance of a novel alcohol‐based skin antiseptic in horses

Abstract: The ABSA tested here provides an efficacious, fast-acting, and well-tolerated alternative to achieve skin antisepsis in healthy horses. These results justify further investigation in clinical cases.

Cited by 6 publications

References 16 publications

Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs

Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs

Equine Skin Antisepsis Using an Alcohol-Based Rub

Comparison of chlorhexidine and alcohol‐based antisepsis of the distal limbs of horses

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