Efficacy and cost of double filtration plasmapheresis in severe hypertriglyceridemia‐induced pancreatitis: A retrospective observational study

Abstract

BackgroundThe value of double ltration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced pancreatitis (sHTGP) is controversial. This study aimed to investigate the e cacy of DFPP on clinical results in patients with sHTGP and the costs associated with the procedure. MethodsPatients who underwent DFPP after admission between January 2016 and December 2021 were recruited. Data on lipid pro le, clinical results, and costs were retrospectively collected and analyzed. ResultsFifty sHTGP patients who received DFPP were enrolled. All of the lipid pro le were signi cantly reduced and maintained a downward trend. The APACHE II score on admission was higher and the reduction after DFPP was more obvious (P < 0.05) in patients with higher triglyceride (TG) levels (≥ 33.9 mmol/L) than in patients with lower TG levels. More material fees were expended in the higher TG group due to more DFPP sessions (P < 0.05), but no signi cant differences existed in total hospital costs between the two groups. ConclusionDFPP could rapidly and effectively reduce TGs to a safe level. APACHE II score reduction was obvious in patients with TGs ≥ 33.9 mmol/L and was associated with lipid pro le changes. DFPP may bene t sHTGP patients with a TG level higher than the current initiation threshold.

Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study

“…Because DFPP has the advantage of reducing the need for fresh frozen plasma (FFP) as a replacement uid and signi cantly reducing the risk of allergic reactions and viral infections secondary to FFP, it has been increasingly used to treat HTG-AP in recent years [20][21][22][23][24][25][26][27] . However, there is little evidence to conclude that DFPP has an effect on improving outcomes of patients with HTG-AP, particularly in terms of reducing organ injury [22][23][24][25] . It has been reported that rapid TG clearance by DFPP in the clinical setting may not translate into a theoretical effect [26][27] .…”