Efficacy and antitumor activity of a mutant type of interleukin 2

Dehghan, Rada; Parikhani, Arezoo Beig; Zeinali, Sirous; Shokrgozar, Mohamadali; Amanzadeh, Amir; Ajdary, Soheila; Cohan, Reza Ahangari; Talebkhan, Yeganeh; Behdani, Mahdi

doi:10.1038/s41598-022-09278-7

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…Therefore, the induced proliferation of UF could be due to the overwhelming influence of excess sodium ions obtained through diets on IL-2. A mutant IL-2 was implicated in inhibiting the progression of a similar tumour, which gives credence to the postulated role of IL-2 in the growth of UF in this study [68]. The influence of the interaction of IL-2 with either zinc, vitamins B1, D, or particularly vitamin A that was implicated in the propagation of UF in this study was reported [69][70][71][72][73].…”

Section: Inflammatory Cytokines In Ufsupporting

confidence: 77%

The Integral Core Nutrient Matrix Causing Uterine Fibroid and the Associated Biochemical Roots

Okesola¹,

Bello²,

Ogunlana³

et al. 2022

Preprint

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Uterine fibroid (UF) is a tumour in some parts of the uterus, which introduces health challenges or death due to failed surgery among women globally. This study was designed to ascertain the involvement of micro-nutrients, inflammation, and antioxidant enzymes in the UF development to gain further insights and provide a strategy for managing the disease. One hundred ninety reproductive-aged women were recruited and classified equally into case and control subjects. The supernatant obtained from excised tissues from the fibroid and the normal samples from the adjacent myometrium were assessed for the selected biochemical parameters with standard methods. The levels of vitamin A and sodium between 26-35 years; vitamins D, E, zinc, and selenium between 46-55 years; and vitamin E at 56 years and above significantly decreased (p&lt;0.05). Interleukin-2 (IL-2) level significantly increased (P &lt; 0.05) among the case between 36-45 years. An increase in the activity of glutathione-s-transferase and the reduction in glutathione peroxidase activity and vitamin A level in the uterus between 26-45 years were the most pronounced significant findings (p&lt;0.05) recorded. Prolonged vitamin A deficiency coupled with excess sodium salts facilitating inflammation induced by IL-2 are critical factors for UF development.

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Section: Inflammatory Cytokines In Ufsupporting

confidence: 77%

The Integral Core Nutrient Matrix Causing Uterine Fibroid and the Associated Biochemical Roots

Okesola¹,

Bello²,

Ogunlana³

et al. 2022

Preprint

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“…The FDA approved the use of high-dose interleukin-2 (IL-2) therapy in 1992 for metastatic renal cell carcinoma and in 1998 for the treatment of metastatic melanoma ( 46 ). A different meta-analysis demonstrates that IL-2 combination medication effectively cures non-small cell lung cancer (NSCLC), increases overall survival, and has few harmful side effects ( 47 ). In individuals with advanced NSCLC, IL-2 serum level determination by regression analysis was demonstrated to have independent predictive value; as a result, its potential application for outcome prediction is advocated ( 48 ).…”

Section: Serum Cytokine Levels As Possible Immunotherapeutic Targetsmentioning

confidence: 99%

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Zhao

Jia²,

Zhang³

2023

Front. Oncol.

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Lung cancer is one of the most prevalent cancer types and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cancer incidences. Lung cancer therapy and prognosis largely depend on the disease’s degree at the diagnosis time. Cytokines are soluble polypeptides that contribute to cell-to-cell communication, acting paracrine or autocrine on neighboring or distant cells. Cytokines are essential for developing neoplastic growth, but they are also known to operate as biological inducers following cancer therapy. Early indications are that inflammatory cytokines such as IL-6 and IL-8 play a predictive role in lung cancer. Nevertheless, the biological significance of cytokine levels in lung cancer has not yet been investigated. This review aimed to assess the existing literature on serum cytokine levels and additional factors as potential immunotherapeutic targets and lung cancer prognostic indicators. Changes in serum cytokine levels have been identified as immunological biomarkers for lung cancer and predict the effectiveness of targeted immunotherapy.

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Monitoring the physiological inflammatory alertness in horse after road transport

Arrigo,

Aragona,

Faggio

et al. 2024

Vet Res Commun

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Efficacy and antitumor activity of a mutant type of interleukin 2

Cited by 7 publications

References 34 publications

The Integral Core Nutrient Matrix Causing Uterine Fibroid and the Associated Biochemical Roots

The Integral Core Nutrient Matrix Causing Uterine Fibroid and the Associated Biochemical Roots

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Monitoring the physiological inflammatory alertness in horse after road transport

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