Efficacy and advantages of modified Traditional Chinese Medicine treatments based on “kidney reinforcing” for chronic aplastic anemia: a randomized controlled clinical trial

Traditional Chinese medicine for treating aplastic anemia

“…All the patients were treated with cyclosporine (CsA) and androgen. After 6 months of treatment, the study showed that the total effective rate of the KA, KQ, and KC groups was higher than that of the positive control group, while the symptoms scores of TCM of the KQ and KC groups were significantly lower than that of the positive control group [5]. Similarly, a prospective, randomized, double-blind, placebo-controlled, multicenter clinical study compared the clinical results of 567 AA patients treated with Bushen Shengxue and Yiqi Yangxue Granules combined with Western medicine.…”

Differentiation of Yin, Yang and Stasis Syndromes in Severe Aplastic Anemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation and Their Correlation with Iron Metabolism, cAMP/cGMP, 17-OH-CS and Thyroxine

“…Our data suggested that the main syndrome of a newly diagnosed patient with SAA was "Yin deficiency with fire hyperactivity" or "heat toxic exacerbation", 20 while those with non-severe chronic AA presented with "kidney deficiency with blood stasis". 10 For patients who were planning to receive stem cell transplantation, the severe infection was kept under control, and the "Heat Toxic" syndrome was alleviated before HSCT. In this study, we found that the 9/18 patients were diagnosed with "Yang deficiency" and 11/18 with "Yin deficiency" before conditioning (two of them deficient in both Yin and Yang).…”

“…8 And the combination of TCM with androgen or IST (cyclosporine with or without anti-thymoglobulin antibody) may significantly improve the overall response rate in patients with AA. [9][10][11][12] In addition, our previous study revealed that the combination of TCM during the HSCT might reduce graft failure, transplant-related mortality and improve the 5 years overall survival. 13 Yet, there are still limited data available on how and when the TCM should be applied.…”

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

“…In 1989, the Dalian National Symposium on Hematology of Integrated Traditional Chinese and Western Medicine associated the classification of AA with the kidney, which was analyzed by syndrome differentiation methods of zang-fu viscera and eight principles. Chronic aplastic anemia belongs to consumptive disease and blood insufficiency, which can be divided into kidney yin deficiency, kidney yang deficiency, and deficiency of both kidney yin and yang [ 21 , 23 ]. In 2008, the China Association of Chinese Medicine issued guidelines for the diagnosis and treatment of common diseases in Chinese medicine, where the syndromes of spleen-kidney yang deficiency, liver-kidney yin deficiency, heat-toxin congestion, and blood heat syndrome were added [ 24 ].…”