Effet protecteur des feuilles de Opilia celtidifolia contre l’ulcère induit par l’éthanol chez le rat

Togola, Adiaratou; Karabinta, K; Dénou, Adama; Haïdara, Mahamane; Sanogo, Rokia; Diallo, Drissa

doi:10.4314/ijbcs.v8i6.5

Cited by 7 publications

(12 citation statements)

References 6 publications

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“…The efficacy of O. celtidifolia extracts could be explained by its richness in various antimicrobial compounds. Previous phytochemical screenings on O. celtidifolia showed several phytochemical compounds such as flavonoids (Mazadu et al, 2018), tannins (Mazadu et al, 2018), alkaloids (Mazadu et al, 2018;Owolabi et al, 2017), terpenoids (Owolabi et al, 2017), coumarins (Togola et al, 2015), polysaccharides of pectin type II (Inngjerdingen et al, 2013), and unsaturated fatty acids (ximenynic acid) (Traore, 2008). These phytomolecules may be responsible of the antibacterial (Górniak et al, 2019;Lopes et al, 2017;Papuc et al, 2017) and antifungal (Merghache et al, 2012) activities of the plant extracts.…”

Section: Minimal Inhibitory Concentration and Minimal Bactericidal Concentration Of The Plant Extractsmentioning

confidence: 99%

Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso

Ollo¹,

Yougbaré²,

Lompo³

et al. 2021

J. Med. Plants Res.

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Section: Minimal Inhibitory Concentration and Minimal Bactericidal Concentration Of The Plant Extractsmentioning

confidence: 99%

Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso

Ollo¹,

Yougbaré²,

Lompo³

et al. 2021

J. Med. Plants Res.

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“…The animal environment was made up of natural air conditioned rooms with optimal air changes per hour, relative humidity, temperature and illumination cycles set to 12h light and 12 hours dark. The animals were accommodated in groups housed in cages with stainless steel grill top, together with facilities for food and water bottle and bedding of clean paddy husk (Togola et al, 2014).…”

Section: Animal Testingmentioning

confidence: 99%

“…The test was done using the Iron per chloride test (Togola et al, 2014), lead acetate test. In a test tube was added 2 ml of the 1% extract followed by a few drops of plead acetate to 10%.…”

Section: Polyphenol Identificationmentioning

confidence: 99%

Phytochemical screening and <i>in vivo</i> evaluation of antiulcer properties of secondary metabolites in aqueous extracts of <i>Ficus. thonningii</i> Blume tested on Wistar rats

Fokunang¹,

pougoue²,

Njunkio³

et al. 2019

Int. J. Bio. Chem. Sci

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Peptic ulcer is an important public health problem affecting about 10% of the world's population. The treatment of this disease is usually long, expensive and less accessibility and affordability of the modern medications by the poor local population. Peptic ulcer represents about 31.65% of cases of consultation in the gastroenterology services in Cameroon. The constraints to have medication have diverted poor patients to rely on traditional medicine for their health problems. The objective of this study was to identify the major classes of secondary metabolites to evaluate in vivo the anti-ulcer activity of the aqueous extracts of Ficus. thonningii on Wistar rats. The experimental model used to induce the gastric ulcers was absolute ethanol 100%. Thirty rats were used for the preventive and curative activity respectively represented in six groups: one group without treatment, three pretreated groups with the extract at (125, 250 and 500 mg/kg), a group receiving a pretreatment with the reference drug omeprazole (20 mg/kg) and another receiving a pretreatment with distilled water (control). Antacid activity was investigated through the determination of the FDA minimal buffer capacity. The phytochemical screening of the extract of the bark showed the presence of the saponins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanin, polyphenols, flavonoïds and betacyanes. Investigation of the in vitro antacid activity of F. thonningii Blume stem bark hydro-ethanolic extract showed that the plant did not possess antacid activity with a 1.18 ± 0.11 minimum buffer capacities after 10 minutes of exposure. In the preventive anti-ulcer study, the percentage protection of the mucous membrane was of 29.80% with 125 mg/kg, 44.27% with 250 mg/kg and 81.18% with 500 mg/kg. This study showed that the hydroethanolic extract of the mixture of the dried bark of Ficus thonningii Blume had a promising gastro-protective activity both preventively and curatively and at 500 mg/kg. The administration of this extract at concentration up to 2000 mg/kg could have a potential effect of vascular protection and hepatic protection.

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“…Animals were fasted for 24 h before the study, 5 but had free access to water. Animals in the control group received only normal saline.…”

Section: Experimental Design and Gastric Ulcer Inductionmentioning

confidence: 99%

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

Marref¹,

Benkiki²,

Melakhessou³

et al. 2018

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Objectives:To evaluate the in vivo anti-ulcer and anti-inflammatory activities of methanol extract of the aerial parts of Gladiolus segetum. Methods: first methanol extract of Gladiolus segetum was subjected to the acute oral toxicity test according to the OECD, guideline no 423.The anti-ulcer activity of Gladiolus segetum was investigated by ethanol induced gastric ulcer in Wistar rats. Methanol extract was administered by gavage one hour before ethanol to the different groups at a dose corresponding of 100,250 and 500 mg/kg body weight. The control group received normal saline in comparable volume (10ml/kg body weight) by the same route. The anti-inflammatory activity of the tested extract was evaluated in adult wistar rats by the egg albumin induced paw edema method. Results: A significant reduction (p <0.001) was observed in the results of the present study, revealed that methanol extract possessed gastroprotective activity and exerts a topical anti-inflammatory effect in vivo. Conclusion: These results suggest that methanol extract of Gladiolus segetum may represent an important clinical alternative in anti-inflammatory and antiulcer genic therapeutics.

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Effet protecteur des feuilles de Opilia celtidifolia contre l’ulcère induit par l’éthanol chez le rat

Cited by 7 publications

References 6 publications

Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso

Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso

Phytochemical screening and <i>in vivo</i> evaluation of antiulcer properties of secondary metabolites in aqueous extracts of <i>Ficus. thonningii</i> Blume tested on Wistar rats

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

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