Effet neuroprotecteur du lactate dans l’hypoxie-ischémie cérébrale néonatale

Roumes, Hélène; Pellerin, Luc; Bouzier‐Sore, Anne‐Karine

doi:10.1051/medsci/2020179

Cited by 1 publication

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“…80 Lactate was also shown to decrease brain lesion volume in several rat models after acute brain injuries such as neonatal hypoxia-ischemia, 38,81 TBI and stroke. 38,[81][82][83][84][85]…”

Section: Prevention Of Neuronal Damagementioning

confidence: 99%

Neuroprotective effects of lactate and ketone bodies in acute brain injury

Plourde,

Roumes,

Suissa

et al. 2024

J Cereb Blood Flow Metab

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The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.

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“…80 Lactate was also shown to decrease brain lesion volume in several rat models after acute brain injuries such as neonatal hypoxia-ischemia, 38,81 TBI and stroke. 38,[81][82][83][84][85]…”

Section: Prevention Of Neuronal Damagementioning

confidence: 99%