Effet de la corticothérapie sur la production des interleukines 8, 12 et du monoxyde d’azote au cours des uvéites Behçet et idiopathique

Belguendouz, Houda; Messaoudene, D.; Hartani, D.; Chachoua, L.; Ahmedi, M.L.; Lahmar-Belguendouz, K.; Lahlou-Boukoffa, O.S.; Touil-Boukoffa, Chafia

doi:10.1016/s0181-5512(08)71433-5

Cited by 27 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we postulated that NO could play an important role in the inflammatory process associated with Adamantiades-Behçet's disease [41]. Several studies have suggested that the overexpression of either inducible NO and proinflammatory cytokines might be intimately involved in the pathogenesis and the evolution of ABD [12,42]. An increase in the concentration of NO during the ABD was reported in several studies and this in both the sera of patients [43] and also in the synovial liquid [44].…”

Section: Discussionmentioning

confidence: 99%

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

et al. 2011

View full text Add to dashboard Cite

BackgroundAdamantiades-Behçet's disease (ABD) is a chronic multisystemic inflammation with unknown pathophysiology. This disorder is associated with a dysregulation of the cytokine network that hyperactivates neutrophils and macrophages. In this study, we investigate the modulatory effects of flavonoïd compounds extracted from Algerian medicinal plant Artemisia herba alba on Th1 and Th2 cytokines and nitric oxide production.MethodsThe modulatory effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production by peripheral blood mononuclear cells isolated from Algerian ABD patients and healthy controls were respectively measured by means of ELISA assays and Griess modified method.ResultsOur results show that flavonoïds significantly reduce the production of interleukin-12, the key effector of T helper 1 (Th1) cells and nitric oxide in a dose-dependent manner in Adamantiades-Behçet's disease. In contrast, the production of IL-4, the key marker of Th2 cells was increased.ConclusionThis study suggests that in vitro supplementation with flavonoïds extracted from Artemisia herba alba could have potential immuno-modulatory effects characterised by a down-regulation and up-regulation of Th1 and Th2 cytokines, respectively. Moreover, flavonoïds may prevent nitric oxide induced damages.

show abstract

Section: Discussionmentioning

confidence: 99%

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

et al. 2011

View full text Add to dashboard Cite

show abstract

“…IL-8 amplification by resident tissues is an important mechanism for the leukocytes to move, especially in avascular tissues, like the cornea. High levels of IL-8 have been regarded as a pathogenic reason in human and in inflammatory diseases and intraocular inflammations [27] [28]. Therefore, increase in IL-8 in tear film of DED patients may be a signal for T lymphocytes to the ocular surface which may lead to damage the cornea and conjunctiva with usual signs of DED.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of IL-6 and IL-8 in Tear Fluid of Sulfur Mustard Gas-Exposed Patients with Eye Lesions

Hosseini¹

2014

OALib

View full text Add to dashboard Cite

The levels of IL-6, 8 in tear fluids of people exposed to mustard gas in the war between Iraq and Iran with chronic dry-eye symptoms were studied. 25 of the patients who were effected with mustard gas and had chronic dry eye symptoms were compared to control group; consisting of 25 people who had common chronic dry eye symptoms with blepharitis and 25 healthy people as normal group. The levels of IL-6 and IL-8 in tear fluids were measured by enzyme-linked immunosorbent assay (ELISA). The results showed that the level of IL-6 (P = 0.002) and IL-8 (P = 0.001) in tear fluid of patients had a significant increase. The differences were considered statistically significant at P < 0.05. The effect of contamination with gas on eyes of injured veterans is destroying meibomian glands whose results are dry eye. As a result, the cited ILs in the tear fluid of these patients increased and resulted in later eye-impairments.

show abstract

Behçet’s disease: An immunogenetic perspective

Salmaninejad

Zamani

Shabgah

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

Behçet’s disease (BD) is a chronic and rare multisystemic disorder defined by autoimmunity and inflammatory characteristics, manifested by ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis as well as neurological, intestinal, and vascular involvement. Despite the unknown cause of BD, there is some strong documentation for immunological, genetic, environmental, and infectious factors playing a role in the pathogenesis of BD. While the nature of the genetic variants remains unidentified, many genetic risk factors are considered to contribute to BD susceptibility. Along with human leukocyte antigen gene encoding B*51 (HLA‐B*51) and areas including the major histocompatibility complex class I, genome‐wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)‐10, IL‐12 receptor β 2 (IL‐12RB2), IL‐23 receptor (IL‐23R), C‐C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin‐like receptor family members (KLRC4‐KLRK1). It is believed that BD could be considered as a disorder lying in between autoimmune and autoinflammatory syndromes. The positive responses to classical immunosuppressive agents like azathioprine and cyclosporine and involvement of autoantigens in the initiation of the disorder are the main BD features that reflect the autoimmune nature of the disorder. In this review, we address recent findings on the role of common cytokines, antibodies and immunogenetic factors in BD.

show abstract

Effet de la corticothérapie sur la production des interleukines 8, 12 et du monoxyde d’azote au cours des uvéites Behçet et idiopathique

Cited by 27 publications

References 41 publications

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

Evaluation of IL-6 and IL-8 in Tear Fluid of Sulfur Mustard Gas-Exposed Patients with Eye Lesions

Behçet’s disease: An immunogenetic perspective

Contact Info

Product

Resources

About