Effet antihypertenseur des feuilles d’Inula viscosa

Abstract

L'effet antihypertenseur de l'extrait aqueux (EA) des feuilles d'Inula viscosa a été évalué sur des rats rendus hypertendus par un traitement au L-NAME (NG-nitro-Larginine méthyle ester). L'évolution de la pression artérielle est évaluée en mesurant la pression artérielle systolique (PAS) à l'aide d'un plétysmographe. Nos investigations ont porté sur trois groupes de rats : un groupe témoin, un groupe traité au L-NAME (30 mg/kg par jour) et un groupe traité au L-NAME (30 mg/kg par jour) et à l'EA d'Inula viscosa à 250 mg/kg par jour. Après quatre semaines de traitement, on note un développement de l'hypertension artérielle (HTA) chez le groupe traité au L-NAME (PAS = 164 ± 3 mmHg), alors que le groupe recevant le L-NAME et l'EA d'Inula viscosa a développé une PAS de 145 ± 2 mmHg seulement. Ces résultats montrent un effet antihypertenseur de cet extrait. De plus, l'étude de l'effet cardiaque de l'EA d'Inula viscosa sur le modèle de coeur isolé et perfusé de rats selon la méthode de Langendorff a montré un effet inotrope négatif dosedépendant qui pourrait expliquer en partie l'effet antihypertenseur trouvé. Mots clés : Extrait aqueux -Inula viscosa -HypertensionPression artérielle systolique -Coeur isoléAntihypertensive effect of an aqueous extract of Inula viscosa leaves Abstract: Inula viscosa (Asteraceae) is a medicinal plant widely used by Mediterranean population in folk medicine to treat different diseases. The antihypertensive effect of the aqueous extract obtained from Inula viscosa leaves was studied in hypertensive rats. Systolic blood pressure was measured using the indirect tail-cuff plethysmographic method (TCP). Three groups of rats were used: control group received water; L-NAME treated group received NG-nitro-L-arginine methylester (30 mg/kg per day) and group received simultaneously L-NAME (30 mg/kg per day) and aqueous extract of Inula viscosa (250 mg/kg per day). After four weeks of treatment, the group receiving the L-NAME alone have developed an arterial hypertension (systolic blood pressure (SBP) = 164 ± 3 mmHg), whereas the group receiving the L-NAME and the aqueous extract of Inula viscosa have developed a SBP of 145 ± 2 mmHg. These results showed that the studied extract prevented significantly the development of hypertension induced by L-NAME. Moreover, the study of the cardiac effect of the Inula viscosa aqueous extract on the model of isolated and perfused rat heart, according to the method of Langendorff, showed a dose-dependent negative inotropic effect, which may contribute to antihypertensive effect.

Phytochemical Profile, Antioxidant Capacity, α-Amylase and α-Glucosidase Inhibitory Potential of Wild Moroccan Inula viscosa (L.) Aiton Leaves

“…I. viscosa root and leaf decoctions have been used as useful and precious remedies for hypertension, diabetes mellitus and cardiac diseases [ 9 , 10 ]. Several recent experimental works have shown that extract of I. viscosa possess antifungal [ 11 ], antibacterial [ 12 ], hypoglycemic [ 13 ], antihypertensive [ 14 ], antiproliferative [ 15 ], anti-inflammatory [ 16 ] and strong antioxidant activity [ 17 , 18 ]. In addition, numerous secondary metabolites, isolated from Inula species, have shown their effectiveness against oxidative stress related diseases (cancer, diabetes and inflammation, etc.…”

Chemotypes and antibacterial activities of Inula viscosa essential oils from Algeria

“…This taxonomic change is confirmed in the online "The Plant List" database. It should also be noted that the name I. viscosa continues to appear in the literature (Kattouf et al 2009;Talib et al 2012;Andolfi et al 2013;Haoui et al 2015;Prisa 2019).…”

Attenuating strategies of the Insecticidal Effect and Life history Traits of Chaitophorus leucomelas (Koch, 1854) (Insecta: Aphididae): Case of the Aqueous Extracts of Asteraceae Dittrichia viscosa and a Synthetic product of the neonicotinoids / pyrethroids Family

“…for a long time(Cafarchia et al 2002;Kattouf et al 2009). D. viscosa is known for its antihypertensive(Kattouf et al 2009), anti-in ammatory and antioxidant(Lounis et al 2009), antidiabetic, antipyretic, wound healing, antiseptic and antiphlogistic activities (Lauro and Rolih 1990; Omezzine et al 2011) and its antiulcerogenic action is attributed to its avonic composition.…”

“…for a long time(Cafarchia et al 2002;Kattouf et al 2009). D. viscosa is known for its antihypertensive(Kattouf et al 2009), anti-in ammatory and antioxidant(Lounis et al 2009), antidiabetic, antipyretic, wound healing, antiseptic and antiphlogistic activities (Lauro and Rolih 1990; Omezzine et al 2011) and its antiulcerogenic action is attributed to its avonic composition. Moreover, extracts of D. viscosa were tested for thier antiviral(Abad et al 2000), antifungal(Mamoci et al 2011), antimicrobial(Maoz and Neeman, 1998), antibacterial(Squalli et al 2007), herbicidal(Muehlchen et al 1990) nematicidal(Oka et al 2006), acaricidal(Mansour et al 2004) and insecticidal activities(Alexenizer and Dorn 2007).…”