Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, Brennan D.; Ampomah, Patrick B.; Yurdagul, Arif; LIU, Chuang; Lauring, Max C.; Wang, Xiaobo; Kasikara, Canan; Kong, Na; Shi, Jinjun; Tao, Wei; Tabas, Ira

doi:10.1016/j.cmet.2021.10.015

Cited by 116 publications

(138 citation statements)

References 69 publications

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“… 64 Apoptotic cell-derived nucleotides activate the proliferation of efferocytosis macrophages, which is essential for inflammation resolution and atherosclerosis regression, which may be new ways to treat non-resolving inflammatory diseases. 65 …”

Section: Cells Involved In Atherosclerosismentioning

confidence: 99%

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Kong

Cui

Huang

et al. 2022

Sig Transduct Target Ther

254

173

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Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, that are associated with the inflammatory response, have been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch and Wnt signaling pathways, which are of importance for atherosclerosis development and regression. Targeting inflammatory pathways, especially the NLRP3 inflammasome pathway and its regulated inflammatory cytokine interleukin-1β, could represent an attractive new route for the treatment of atherosclerotic diseases. Herein, we summarize the knowledge on cellular participants and key inflammatory signaling pathways in atherosclerosis, and discuss the preclinical studies targeting these key pathways for atherosclerosis, the clinical trials that are going to target some of these processes, and the effects of quelling inflammation and atherosclerosis in the clinic.

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Section: Cells Involved In Atherosclerosismentioning

confidence: 99%

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Kong

Cui

Huang

et al. 2022

Sig Transduct Target Ther

254

173

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“…Efferocytosis is a key step in the resolution of inflammation and is linked with initiation of reparative responses. 21 , 64 Therefore, we next evaluated whether MCTR3 reprogramming enhanced the ability of joint macrophage to upregulate the clearance of apoptotic cells. Flow cytometric analysis demonstrated a significant increase in the levels of macrophages carrying apoptotic neutrophils, as shown by an increase in the number of macrophages expressing the neutrophil marker Ly6G ( Figure 6 f).…”

Section: Resultsmentioning

confidence: 99%

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis

Pistorius

Souza

et al. 2022

eBioMedicine

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“…MERTK-binding bridging molecules contribute to efferocytosis-associated inflammatory resolution (Nishi et al, 2014;Toda et al, 2014), while the Tyro3-Ax1-MERTK (TAM) family of receptor tyrosine kinases in macrophages is involved in the recognition and clearance of dead cells, as well as the activation of antiinflammatory signals (Qi et al, 2013;Toda et al, 2014;Bernsmeier et al, 2015). Furthermore, efferocytosis can promote non-inflammatory macrophage proliferation to help resolve tissue injury via inducing DNA-dependent protein kinase-mammalian target of rapamycin-rictor complex 2/ Rictor pathway (Gerlach et al, 2021).…”

Section: Efferocytosis In Immune Cells and Underlying Regulatory Mech...mentioning

confidence: 99%

Efferocytosis and Its Role in Inflammatory Disorders

Huang

Yao

2022

Front. Cell Dev. Biol.

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Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation of apoptotic cells. Defective efferocytosis has been demonstrated to associate with the pathogenesis of various inflammatory disorders. In the current review, we summarize recent findings with regard to efferocytosis networks and discuss the relationship between efferocytosis and different immune cell populations, as well as describe how efferocytosis helps resolve inflammatory response and modulate immune balance. Our knowledge so far about efferocytosis suggests that it may be a useful target in the treatment of numerous inflammatory diseases.

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Efferocytosis induces macrophage proliferation to help resolve tissue injury

Cited by 116 publications

References 69 publications

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis

Efferocytosis and Its Role in Inflammatory Disorders

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