Efferents and centrifugal afferents of the main and accessory olfactory bulbs in the hamster

Davis, Barry J.; Macrides, Foteos; Youngs, William M.; Schneider, Stephen P.; Rosene, Douglas L.

doi:10.1016/0361-9230(78)90062-x

Cited by 269 publications

(159 citation statements)

References 39 publications

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“…The vomeronasal (VN) or accessory olfactory system is a second chemosensory system organized in parallel with the main olfactory system, and with anatomically distinct pathways (Scalia and Winans, 1975;Davis et al, 1978). The vomeronasal organs (VNOs) are tubular structures lying bilaterally in the ventral part of the nasal cavity.…”

mentioning

confidence: 99%

“…Vomeronasal receptor neurons project to the accessory olfactory bulb (AOB) (Barber and Raisman, 1974) from which fibers project to two parts of the amygdala, the medial nucleus (Me) and the posterior medial cortical nucleus (PMCN), collectively called the vomeronasal amygdala (Kevetter and Winans,198 1 a). The vomeronasal amygdala, and the AOB in some species, projects via the stria terminalis to the medial bed nucleus of the stria terminalis (mBNST) (Scalia and Winans, 1976;Davis and Macrides, 1978;Lehman and Winans, 1983). The Me also has projections via the ventral amygdaloid pathway and the stria terminalis to the medial preoptic anterior hypothalamic area and BNST (Lehman and Winans, 1983) and these regions also project to the ventromedial nucleus of the hypothalamus (VmH).…”

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confidence: 99%

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c-fos expression in vomeronasal pathways of mated or pheromone- stimulated male golden hamsters: contributions from vomeronasal sensory input and expression related to mating performance

1994

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The vomeronasal system projects to the accessory olfactory bulb (AOB), to the medial (Me) and posterior medial cortical nuclei (PMCN) of the amygdala, to the bed nucleus of the stria terminalis (BNST), and to other central structures shown to be important in mating behavior, including the medial preoptic area (MPOA). In these experiments c-fos expression was used as a marker of neural activity to identify the contribution of vomeronasal sensory input during mating behavior in male golden hamsters, either intact or with vomeronasal organs removed (VNX). Inexperienced hamsters were either stimulated with a receptive female and allowed to mate, exposed to female hamster vaginal fluid (HVF), which contains stimuli known to act through the VN system, or placed in a clean cage alone. Densely stained Fos-positive nuclei were evident in mated animals in the central VN pathway [AOB, Me, posterior medial BNST (pmBNST)] and a VN target area (MPOA). HVF-exposed animals showed Fos expression in the AOB, Me, and BNST but not MPOA. Unstimulated animals showed almost no activation. Most VNX animals exposed to females did not mate, but performed intense chemoinvestigation. They had few Fos-positive nuclei in any of these areas except the caudal pmBNST. A few VNX animals that did mate had patterns of Fos activation that were similar but less intense than those of intact mating animals, suggesting a selective activation of VN central pathways during mating regardless of VN sensory input. The main olfactory system showed low levels of Fos expression in all animals (stimulated and unstimulated). Fos expression in the MPOA and rostral pmBNST was seen only in mated animals, suggesting that these regions are concerned with mating performance or its consequences, rather than the chemosensory input that triggers it. Fos expression in the caudal encapsulated pmBNST was evident in all groups of animals that performed chemosensory investigation, regardless of VN status or mating, suggesting that this region either directs or responds to chemosensory investigation.

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confidence: 99%

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confidence: 99%

c-fos expression in vomeronasal pathways of mated or pheromone- stimulated male golden hamsters: contributions from vomeronasal sensory input and expression related to mating performance

1994

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“…A key advantage of the olfactory system is that the efferent projections of the olfactory bulbs are massively ipsilateral. In tract-tracing studies of hamster olfactory bulb, no contralateral labeling in the ventral forebrain or amygdala was observed with injections of anterograde tracers into either the main or accessory olfactory bulbs (Davis et al, 1978). Connections between paired subnuclei of Me and MPOA through the anterior commissure link the two hemispheres (Maragos et al, 1989;Gomez and Newman, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Male hamsters that are bilaterally bulbectomized do not mate, and hence DA does not increase. We used Ubx to take advantage of the predominantly ipsilateral projections of the olfactory bulbs (Davis et al, 1978). Ubx males can mate, but they do not receive chemosensory stimuli ipsilateral to the lesioned bulb.…”

Section: Discussionmentioning

confidence: 99%

“…Males were unilaterally bulbectomized to eliminate chemosensory input in ipsilateral or contralateral MPOA. Unilateral olfactory bulbectomy takes advantage of the predominantly ipsilateral projections of the olfactory bulbs (Davis et al, 1978), and does not prevent normal sexual behavior (Winans and Powers, 1974). By contrast, bilateral removal of the olfactory bulbs immediately and permanently abolishes mating (Murphy and Schneider, 1970).…”

Section: Introductionmentioning

confidence: 99%

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Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

Triemstra

Nagatani

Wood

2005

Neuropsychopharmacol

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The medial preoptic area (MPOA) is crucial for male sex behavior. Dopamine (DA) is released in MPOA during copulation, and contributes to the reinforcing effects of mating. The aim of the present study was to identify sensory stimuli responsible for matinginduced DA release. Specifically, we determined if chemosensory cues are essential for mating-induced MPOA DA release using in vivo microdialysis in male Syrian hamsters. Hamsters were used because chemosensory cues from the olfactory mucosa and vomeronasal organ are essential for sexual behavior in this species. Sexually experienced adult male hamsters were implanted with a microdialysis guide cannula over MPOA. At the same time, males received sham olfactory bulbectomy (Sham Bx, n ¼ 11), bilateral bulbectomy (Bibx, n ¼ 6), or unilateral bulbectomy (Ubx) ipsilateral (Ipsi Ubx, n ¼ 9) or contralateral (Contra Ubx, n ¼ 8) to the microdialysis probe. This model takes advantage of the predominantly ipsilateral projections of the olfactory bulbs. Microdialysis samples were collected from the MPOA during baseline, exposure to a receptive female, and after removal of female. Extracellular DA was measured using highperformance liquid chromatography with electrochemical detection. During mating, DA increased in MPOA of Sham Bx males (to 146.7717.5% of baseline). Bibx males did not mate, and MPOA DA did not increase (96.1715.8% of baseline). Although both groups of Ubx males mated to ejaculation, MPOA DA increased significantly only in Contra Ubx males (to 161.8735.3% of baseline), and not in males with Ipsi Ubx (107.6711.5% of baseline). The results demonstrate that chemosensory cues are essential for MPOA DA release during mating in male Syrian hamsters.

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Bidirectional connections of the medial amygdaloid nucleus in the Syrian hamster brain: Simultaneous anterograde and retrograde tract tracing

1998

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In the male Syrian hamster, mating is dependent on chemosensory and hormonal stimuli, and interruption of either input prevents copulation. The medial amygdaloid nucleus (Me) is a key nodal point in the neural circuitry controlling male sexual behavior because it relays both odor and steroid cues. Me is comprised of two major subdivisions, anterior (MeA) and posterior (MeP), which have distinct, although overlapping efferent projections. The present study investigated the afferents and efferents of MeA and MeP by using combined anterograde and retrograde tract tracing. Phaseolus vulgaris-leucoagglutinin and cholera toxin B were injected by iontophoresis through a single glass micropipette and detected by immunohistochemistry. MeA has widespread connections with olfactory structures, whereas MeP is heavily interconnected with steroid-responsive brain regions. The efferent projections of MeA and MeP were similar to those reported previously for the rat and hamster. In particular, MeP projects to the posteromedial subdivision of the bed nucleus of the stria terminalis (BNST) and to the medial preoptic nucleus, whereas MeA projects to adjacent subnuclei in BNST and the preoptic area. MeA and MeP also have distinct patterns of afferent input. Furthermore, the combination of anterograde and retrograde tract tracers shows that MeA and MeP are each bidirectionally connected with each other and with limbic nuclei. These results demonstrate that subnuclei of Me are interconnected with limbic structures in hamster brain. These connections may contribute to chemosensory and hormonal integration to control male sexual behavior.

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Efferents and centrifugal afferents of the main and accessory olfactory bulbs in the hamster

Cited by 269 publications

References 39 publications

c-fos expression in vomeronasal pathways of mated or pheromone- stimulated male golden hamsters: contributions from vomeronasal sensory input and expression related to mating performance

c-fos expression in vomeronasal pathways of mated or pheromone- stimulated male golden hamsters: contributions from vomeronasal sensory input and expression related to mating performance

Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

Bidirectional connections of the medial amygdaloid nucleus in the Syrian hamster brain: Simultaneous anterograde and retrograde tract tracing

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