Efferent fiber projections of the habenula and the interpeduncular nucleus. An experimental study in the opossum and cat

Smaha, L.A.; Kaelber, William W.

doi:10.1007/bf00233332

Cited by 68 publications

(11 citation statements)

References 14 publications

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“…In the present study, few VHb (and not DHb) fibers diverged from the fasciculus retroflexus and reached via the medial forebrain bundle the rostral ventral hypothalamus. This is in accordance with the description of LHb (and not MHb) efferents in the cat, opossum, and rat (Akagi & Powell, ; Araki et al, ; Herkenham & Nauta, ; Smaha & Kaelber, ), as well as to the projection of the fasciculus retroflexus in the Tenerife lizard (Díaz & Puelles, ). In B. orientalis , an extensive overlap of axonal projections between VHb and DHb was suggested, including the projection to the alar and tuberal hypothalamus.…”

Section: Discussionsupporting

confidence: 91%

“…It was therefore argued that the context, in which the habenula circuitry is recruited might have changed (Stephenson‐Jones, Floros, et al, ). Habenular efferents terminate predominantly in diencephalic, mesencephalic, and rhombencephalic areas, with an additional forebrain projection in tetrapods [lampreys: Yáñez & Anadón, , Stephenson‐Jones, Floros, et al, ; chondrichthyes: Giuliani et al, ; teleosts: Villani et al, , Yáñez & Anadón, , Amo et al, ; amphibians: Kemali et al, , Laberge & Smith, , present study; reptiles: Distel & Ebbesson, , Díaz & Puelles, ; mammals: Cragg, , Akagi & Powell, , Smaha & Kaelber, , Herkenham & Nauta, , Araki, McGeer, & Kimura, ]. In the course of vertebrate evolution, the primordial habenula circuitry seemingly underwent various evolutionary adaptations and the complexity of the afferent and efferent connectivity increased in the tetrapod line.…”

Section: Discussionmentioning

confidence: 54%

“…The afferent habenula connectivity is based on lamprey: Yáñez and Anadón (), Stephenson‐Jones, Floros, et al (2012), Ocaña et al, ; amphibians: Present study; mammals: Herkenham and Nauta (), McBride (), Parent et al (). The efferent habenula connectivity is based on: Lamprey: Yáñez and Anadón (), Stephenson‐Jones, Floros, et al, ; amphibians: Present study; mammals: Cragg (), Akagi and Powell (), Smaha and Kaelber (), Herkenham and Nauta (), Araki et al (). Brains (a,b) are redrawn after Nieuwenhuys, ten Donkelaar, and Nicholson ().…”

Section: Discussionmentioning

confidence: 99%

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The habenula as an evolutionary conserved link between basal ganglia, limbic, and sensory systems—A phylogenetic comparison based on anuran amphibians

Freudenmacher

Twickel

Walkowiak

2019

J of Comparative Neurology

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Based on anatomical and functional data, the habenula—a phylogenetically old brain structure present in all vertebrates—takes part in the integration of limbic, sensory, and basal ganglia information to guide effective response strategies appropriate to environmental conditions. In the present study, we investigated the connections of the habenular nuclei of the oriental fire‐bellied toad, Bombina orientalis, and compared them with published data from lampreys, chondrichthyes, teleosts, reptiles, birds, and mammals. During phylogenetic development, the primordial habenula circuitry underwent various evolutionary adaptations and in the tetrapod line, the circuit complexity increased. The habenula circuitry of anuran amphibians, decedents of the first land‐living tetrapods, seem to exhibit a mix of ancient as well as modern features. The anuran medial and lateral habenula homologs receive differential input from the septum, nucleus of the diagonal band of Broca, preoptic area, hypothalamus, rostral pallium, nucleus accumbens, ventral pallidum, and bed nucleus of the stria terminalis. Additional input arises from a border region in the ventral prethalamus, here discussed as a putative homolog of the entopeduncular nucleus of rodents. The habenular subnuclei also differentially innervate the interpeduncular nucleus, raphe nuclei, substantia nigra pars compacta and ventral tegmental area homologs, superficial mamillary area, laterodorsal tegmental nucleus, locus coeruleus, inferior and superior colliculus homologs, hypothalamus, preoptic area, septum, nucleus of the diagonal band of Broca, and main olfactory bulb. It seems likely that the main connectivity between the habenula and the basal ganglia, limbic, and sensory systems was already present in the common tetrapod ancestor.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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The habenula as an evolutionary conserved link between basal ganglia, limbic, and sensory systems—A phylogenetic comparison based on anuran amphibians

Freudenmacher

Twickel

Walkowiak

2019

J of Comparative Neurology

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“…In addition, anterograde fiber degeneration techniques and electron microscopy revealed secondary afferent projections, which have been reviewed elsewhere (Sutherland, 1982; Bianco and Wilson, 2009). These latter techniques also identified projections innervating the medial habenula subnucleus from mainly the hypothalamic area and the precommisural septum but also the lateral preoptic area, the interpeduncular nucleus (IPN), the dorsal raphe nucleus, and the superior cervical ganglion (Mitchell, 1963; Zyo et al, 1963; Powell, 1968; Smaha and Kaelber, 1973; Pierce et al, 1976). …”

Section: Anatomy and Connectivity Of The Dorsal Diencephalic Conductimentioning

confidence: 99%

Habenula Circuit Development: Past, Present, and Future

Beretta¹,

Dross²,

Guiterrez-Triana³

et al. 2012

Front. Neurosci.

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The habenular neural circuit is attracting increasing attention from researchers in fields as diverse as neuroscience, medicine, behavior, development, and evolution. Recent studies have revealed that this part of the limbic system in the dorsal diencephalon is involved in reward, addiction, and other behaviors and its impairment is associated with various neurological conditions and diseases. Since the initial description of the dorsal diencephalic conduction system (DDC) with the habenulae in its center at the end of the nineteenth century, increasingly sophisticated techniques have resolved much of its anatomy and have shown that these pathways relay information from different parts of the forebrain to the tegmentum, midbrain, and hindbrain. The first part of this review gives a brief historical overview on how the improving experimental approaches have allowed the stepwise uncovering much of the architecture of the habenula circuit as we know it today. Our brain distributes tasks differentially between left and right and it has become a paradigm that this functional lateralization is a universal feature of vertebrates. Moreover, task dependent differential brain activities have been linked to anatomical differences across the left–right axis in humans. A good way to further explore this fundamental issue will be to study the functional consequences of subtle changes in neural network formation, which requires that we fully understand DDC system development. As the habenular circuit is evolutionarily highly conserved, researchers have the option to perform such difficult experiments in more experimentally amenable vertebrate systems. Indeed, research in the last decade has shown that the zebrafish is well suited for the study of DDC system development and the phenomenon of functional lateralization. We will critically discuss the advantages of the zebrafish model, available techniques, and others that are needed to fully understand habenular circuit development.

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“…A conclusion in regard to these subdivisions has yet to be clearly established, as seen in the disagreement between Ives (18) and Plante (30). Until recently, studies designed to determine the functional significance of the IPN have tended to assume that this structure may have homogeneous cytoarchitectonics (21,28,44).…”

mentioning

confidence: 99%

Enzyme-Histochemical Study on the Nucl. Interpeduncularis of the Rat Brain

Imai

1978

Acta Histochem. Cytochem

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Efferent fiber projections of the habenula and the interpeduncular nucleus. An experimental study in the opossum and cat

Cited by 68 publications

References 14 publications

The habenula as an evolutionary conserved link between basal ganglia, limbic, and sensory systems—A phylogenetic comparison based on anuran amphibians

The habenula as an evolutionary conserved link between basal ganglia, limbic, and sensory systems—A phylogenetic comparison based on anuran amphibians

Habenula Circuit Development: Past, Present, and Future

Enzyme-Histochemical Study on the Nucl. Interpeduncularis of the Rat Brain

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