Efferent connections of the vestibular nuclei in the rat: a neuromorphological study using PHA-L

Matesz, Clara; Bácskai, Tímea; Nagy, Éva; Halasi, Gabor; Kulik, Ákos

doi:10.1016/s0361-9230(01)00726-2

Cited by 32 publications

(23 citation statements)

References 3 publications

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“…Anterograde tracing methods in the rat suggest that vestibular inputs originate from the MVN and SVN (Matesz et al, 2002). VPM neurons have been shown to respond to rotational and translational vestibular stimulation (Matsuo et al, 1994(Matsuo et al, , 1995(Matsuo et al, , 1999Meng et al, 2007) as well as to electrical stimulation of the vestibular nerve (Blum et al, 1979b;Blum and Gilman, 1979;Deecke et al, 1977;Matsuo et al, 1994Matsuo et al, , 1999Meng et al, 2001).…”

Section: Vestibular Projections To the Ventroposterior Complexmentioning

confidence: 99%

“…Regarding vestibular processing, anatomical studies have stressed the importance of the centromedian nucleus (or parafascicular nucleus in the rat), the central lateral nucleus, and the paracentral nucleus (Blum et al, 1979b;Blum and Gilman, 1979;Kotchabhakdi et al, 1980;Lai et al, 2000;Magnin and Kennedy, 1979;Matsuo et al, 1994;Meng et al, 2001Meng et al, , 2007Nagata, 1986;Raymond et al, 1976;Shiroyama et al, 1995). The centromedian/ parafascicular nucleus receives vestibular information mainly from the MVN bilaterally, with an ipsilateral dominance, and from the SVN and the DVN ipsilaterally (Lai et al, 2000;Matesz et al, 2002;Shiroyama et al, 1995). The central lateral nucleus appears to receive many fibers only from the contralateral SVN, while the paracentral nucleus receives fibers mainly from the contralateral MVN and SVN, and bilaterally from the DVN (Kotchabhakdi et al, 1980).…”

Section: Vestibular Projections To the Intralaminar Nucleimentioning

confidence: 99%

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The thalamocortical vestibular system in animals and humans

Lopez

Blanke

2011

Brain Research Reviews

458

379

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The vestibular system provides the brain with sensory signals about three-dimensional head rotations and translations. These signals are important for postural and oculomotor control, as well as for spatial and bodily perception and cognition, and they are subtended by pathways running from the vestibular nuclei to the thalamus, cerebellum and the "vestibular cortex."The present review summarizes current knowledge on the anatomy of the thalamocortical vestibular system and discusses data from electrophysiology and neuroanatomy in animals by comparing them with data from neuroimagery and neurology in humans. Multiple thalamic nuclei are involved in vestibular processing, including the ventroposterior complex, the ventroanterior-ventrolateral complex, the intralaminar nuclei and the posterior nuclear group 2 0 1 1 ) 1 1 9 -1 4 6 Abbreviations: 3aHv, 3a-hand-vestibular area; 3aNv, 3a-neck-vestibular area; ASS, anterior suprasylvian cortex; DVN, descending vestibular nucleus; FEF, frontal eye fields; Ig, insula granularis; IL, intralaminar nuclei; LD, lateral dorsal nucleus; LGN, lateral geniculate nucleus; LP, lateral posterior nucleus; LVN, lateral vestibular nucleus; MGmc, medial geniculate nucleus, pars magnocellularis; MGN, medial geniculate nucleus; MIP, medial intraparietal area; MST, medial superior temporal area; MT, middle temporal area; MVN, medial vestibular nucleus; PIVC, parieto-insular vestibular cortex; PO, posterior group of the thalamus; Reipt, area retroinsularis pars parietalis; Ri, area retroinsularis; SGN, suprageniculate nucleus; SVN, superior vestibular nucleus; TPJ, temporo-parietal junction; VA, ventroanterior thalamic nucleus; Vim, nucleus ventralis intermedius; VIP R A I N R E S E A R C H R E V I E W S 6 7 (

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Section: Vestibular Projections To the Ventroposterior Complexmentioning

confidence: 99%

Section: Vestibular Projections To the Intralaminar Nucleimentioning

confidence: 99%

The thalamocortical vestibular system in animals and humans

Lopez

Blanke

2011

Brain Research Reviews

458

379

View full text Add to dashboard Cite

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“…In adult animals, retrograde tracing demonstrated direct projections from MV and SpV to IO subnucleus DMCC (Barmack, 1996;Matesz et al, 2002), which together with subnucleus IO␤ also receives projection from parasolitary nucleus located next to the vestibular nuclear complex (Barmack et al, 1998). IO is also one of the major brainstem recipients of projections from the PrH (rat: de Zeeuw et al, 1998;monkey: Belknap and McCrea, 1988).…”

Section: Inferior Olivementioning

confidence: 99%

Maturation of canal‐related brainstem neurons in the detection of horizontal angular acceleration in rats

Lai

Yiu

Lai

et al. 2010

J of Comparative Neurology

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We examined the functional maturation of canal-related brainstem neurons in Sprague-Dawley rats at postnatal day (P)1 to adult. Conscious animals were subjected to cycles of angular acceleration and deceleration so as to selectively activate hair cells of the horizontal semicircular canals. Brainstem neurons were monitored for c-fos expression by immuno-hybridization histochemistry as an indicator of neuronal activation. Fos-immunoreactive canal-related neurons were identifiable from P4 onwards in the vestibular nucleus and downstream vestibular relay stations, prepositus hypoglossal nucleus, and inferior olive. In the vestibular nucleus and prepositus hypoglossal nucleus, the number of canal-related neurons increased progressively with age, reaching the adult level by P21. Those in the inferior olive increased in number from P4 to P14 but decreased significantly afterwards until adulthood. The topography was not clear in the vestibular nucleus and prepositus hypoglossal nucleus. Canal-related neurons in P4-7 rats were spread throughout the rostrocaudal length of each subnucleus but clusters of canal-related neurons tended to form within specific subnuclei by P21. These were concentrated in the caudal halves of medial and spinal vestibular nuclei and the rostral parts of superior vestibular nucleus and prepositus hypoglossal nucleus. In the inferior olive, the topography was evident early in the course of development. Canal-related neurons were exclusively located in four subnuclei: dorsal medial cell column, dorsal cap, subnucleus A, and subnucleus C, but not in other subnuclei. Taken together, our data revealed the developmental profile of neuronal subpopulations within the horizontal canal system, thus providing an internal neural representation for postnatal coding of horizontal head rotations in spatial perception.

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“…The present data demonstrate that the E 2 -treated animals regardless of their oligo treatment were more responsiveness to the first (vestibular) sensory stimulus compared with the oil-treated controls such that the administration of the stimulus results in prolonged and increased home cage activity. The medial, superior, and lateral divisions of the vestibular nucleus send extensive projections to the medullary and pontine reticular formation, thus, providing an increased impetus for arousal when stimulated (44)(45)(46)(47). The fact that the response of the AS oil-treated animals mimicked that of the E 2 groups suggests that PGD 2 plays a role in mediating the arousing effects of E 2 .…”

Section: Discussionmentioning

confidence: 97%

Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior

Mong

Devidze²,

Goodwillie³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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In female rodents, sleep and activity levels fluctuate over the estrous cycle. When estradiol (E 2) levels are highest, sleep is reduced whereas locomotion is increased. The preoptic area (POA) is a key site for estrogenic regulation of these functions. However, molecular mechanisms by which E 2 acts to reduce sleep and increase activity are unclear. Recently, we demonstrated a twofold reduction in lipocalin-type prostaglandin D synthase (L-PGDS) transcript levels, after E 2 treatment, in the ventrolateral POA (VLPO), a putative sleep-active nucleus. Catalytic activity of L-PGDS produces PGD 2, an endogenous somnogen. Thus, we hypothesized that decreases in PGD 2 in the VLPO may contribute to the generalized arousal mediated by estrogens. To test this, we infused (i) antisense oligonucleotides (oligos), containing locked nucleic acid moieties (an improved technology), targeted to L-PGDS mRNA, (ii) scrambled sequence control oligos, or (iii) saline vehicle into the VLPO of ovariectomized female mice treated with E 2 or oil. Arousal states and activity levels were assessed in response to a series of sensory stimuli (vestibular, olfactory, and somatosensory). The vestibular stimulus, which was administered first, resulted in the strongest responses and elicited significantly different responses among the groups: all groups in the E 2 cohort demonstrated increases in overall home cage activity and duration of that activity compared with the oil-treated control groups. As predicted from E 2 suppression of L-PGDS transcript levels, the responses of the locked nucleic acid antisense oligo-treated animals from the oil cohort did not differ from the E 2-treated groups, such that they also demonstrated increases in activity and duration of activity compared with their controls. Thus, reducing L-PGDS in the VLPO of oil-treated females mimicked the effect of E 2 on activity and arousal and represents a unique molecular pathway through which E 2 may modulate these functions.antisense ͉ genomics ͉ sleep ͉ locomotion ͉ neuroendocrine A ctivity levels and sleep homeostasis fluctuate over the estrous cycle in female rodents. Sleep is typically reduced and motor activity is increased during the proestrous dark period when estradiol (E 2 ) levels are highest (1, 2). It is well established that estrogens are responsible for increases in activity in rats (3-7) and, more recently, Morgan et al. (8) have extended this finding to mice. E 2 -treated females demonstrated increased running wheel activity as well as general home cage activity that included rearing, grooming, and burying. These data indicate that E 2 has an arousing effect allowing for increased locomotor behaviors, a component of estrogen-facilitated courtship responses. Cell groups in the preoptic area (POA) have been implicated in the regulation of sleep (reviewed in ref. 9) and the estrogenic mediation of locomotion (10). What molecular mechanisms may underlie E 2 effects on activity and sleep?Our high-density oligonucleotide (oglio) microarray screens have been useful...

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Efferent connections of the vestibular nuclei in the rat: a neuromorphological study using PHA-L

Cited by 32 publications

References 3 publications

The thalamocortical vestibular system in animals and humans

The thalamocortical vestibular system in animals and humans

Maturation of canal‐related brainstem neurons in the detection of horizontal angular acceleration in rats

Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior

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