Effelct of Plasmapheresis in Myasthenia Gravis

Plasma Exchange and Intravenous Immunoglobulin in Autoimmune Myasthenia Gravisa

“…Dau reported an improvement in 44 out of 60 patients treated by weekly PE and immunosuppressive drugs. 2 Perlo 3 has treated 17 MG patients with 3–5 exchanges given over a period of 1–2 weeks. Results were graded as good or excellent for 11 and as fair for 7.…”

“…Second, the schedule of PE is different from one study to another. Most authors use 3 to 5 sessions for 5 to 15 days, 3,6 but Antozzi 5 has obtained good results with only 2 PE every other day. Exchanged volumes range from 1 to 4 liters per session.…”

Clinical trials for myasthenia gravis: a historical perspective

“…ended in 1981 . We count 10 reports of therapies, five of which focused on plasma exchange used in combination with other treatments or in isolation . All of the investigations were retrospective, with no control groups for the exchange.…”

“…11 We count 10 reports of therapies, [28][29][30][31][32] five of which focused on plasma exchange used in combination with other treatments or in isolation. [33][34][35][36][37] All of the investigations were retrospective, with no control groups for the exchange. Olarte and colleagues stated "it would take a controlled trial to determine when the use plasmapheresis actu-ally shortens the duration of myasthenic crisis."…”

Predictable recovery from myasthenia gravis crisis with plasma exchange: Thirty-six cases and review of current management

“…It soon became obvious that Myasthenia Gravis (MG), which needed more than standard therapies, would provide the niche for PEX [6]. When MG is not controlled with anti-cholinesterase, thymectomy, and immunosuppressive therapy, PEX will facilitate management of the disease [7][8][9][10] and markedly shorten the duration of a crisis.…”