Effects triggered by platinum nanoparticles on primary keratinocytes

Konieczny, Piotr; Goralczyk, Anna Grazyna; Szmyd, Radosław; Skalniak, Łukasz; Kozieł, Joanna; Filon, Francesca Larese; Crosera, Matteo; Cierniak, Agnieszka; Zuba‐Surma, Ewa; Borowczyk, Julia; Łaczna, Eliza; Drukała, Justyna; Pyza, Elżbieta; Semik, D; Woźnicka, Olga; Klein, Andrzej; Jura, Jolanta

doi:10.2147/ijn.s49612

Cited by 22 publications

(17 citation statements)

References 31 publications

(41 reference statements)

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“…Interestingly, PtNPs are well documented as reactive oxygen species (ROS) scavengers and have been shown to reduce intracellular reactive oxygen in the presence of other stressors [ 15 , 16 ]. However, in some cases, PtNPs elicited negative bioresponses including the activation of cellular stress, as well as DNA damage and genotoxicity effects in vitro [ 17 – 19 ]. In a zebrafish model, PtNP addition resulted in developmental alterations and a concentration dependent drop in heart rate, demonstrating that PtNP-dependent effects translated into in vivo models [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…The goal of this study was to enhance the current state of knowledge regarding cellular response following PtNP introduction in vitro . This work employed the human liver, HepG2, cell model as PtNPs have been shown to accumulate in the liver, making it a relevant nanotoxicological target [ 17 ]. Select endpoints included both traditional toxicological evaluations and biological responses frequently overlooked in safety evaluations, such as the activation of an inflammatory response and modulation of signal transduction pathways.…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro

Labrador-Rached

Browning

Braydich‐Stolle

et al. 2018

Journal of Toxicology

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Due to their distinctive physicochemical properties, platinum nanoparticles (PtNPs) have emerged as a material of interest for a number of biomedical therapeutics. However, in some instances NP exposure has been correlated to health and safety concerns, including cytotoxicity, activation of cellular stress, and modification to normal cell functionality. As PtNPs have induced differential cellular responses in vitro, the goal of this study was to further characterize the behavior and toxicological potential of PtNPs within a HepG2 liver model. This study identified that a high PtNP dosage induced HepG2 cytotoxicity. However, lower, subtoxic PtNP concentrations were able to elicit multiple stress responses, secretion of proinflammatory cytokines, and modulation of insulin-like growth factor-1 dependent signal transduction. Taken together, this work suggests that PtNPs would not be overtly toxic for acute exposures, but sustained cellular interactions might produce long term health consequences.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro

Labrador-Rached

Browning

Braydich‐Stolle

et al. 2018

Journal of Toxicology

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“…It is worth to mention that these effects have no influence on migration or cell viability. Smaller nanoparticles exhibit more deleterious effects on DNA stability and higher caspases activation than the bigger ones [30].…”

Section: Dermal Exposurementioning

confidence: 97%

“…Konieczny et al in their studies focused on the effects of polyvinylpyrrolidone-coated platinum nanoparticles (5.8 and 57 nm) and demonstrated that PtNPs triggered toxic effects on primary keratinocytes, decreasing cell metabolism [30]. It is worth to mention that these effects have no influence on migration or cell viability.…”

Section: Dermal Exposurementioning

confidence: 99%

Are platinum nanoparticles safe to human health?

Czubacka

Czerczak

2019

Med Pr

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Platinum nanoparticles (PtNPs) have been widely used not only in industry, but above all in medicine and diagnostics. However, there are disturbing reports related to the toxic effects of nanoplatinum, which is the main reason why the authors of this study have decided to review and analyze literature data related to its toxicity and impact on human health. While PtNPs may be absorbed by the respiratory and digestive tract, and can penetrate through the epidermis, there is no evidence concerning their absorption through the skin. Platinum nanoparticles accumulate mainly in the liver and spleen although they also reach other internal organs, such as lungs, kidneys or heart. Toxicokinetics of platinum nanoparticles depends strongly on the particle size. Only few studies regarding platinum nanoparticles toxicity have been conducted. Animals intratracheally exposed to platinum nanoparticles have demonstrated an increased level of proinflammatory cytokines in bronchoalveolar lavage which confirms inflammatory response in the lungs. Oral administration of PtNPs can cause inflammatory response and induce oxidative stress. Nanoplatinum has been found to induce hepatotoxicity and nephrotoxicity via the intravenous route. It can cause DNA damage and cellular apoptosis without significant cytotoxicity. There are no research studies on its carcinogenicity. Fetal or maternal toxicity has not been observed, but an increased mortality and a decreased growth of the offspring have been demonstrated. Platinum nanoparticles may permeate the skin barrier but there is no evidence for their absorption. Due to the insufficient number of tests that have been carried out to date, it is not possible to clearly determine the occupational exposure limit value; however, caution is recommended to employees exposed to their effects.

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“…The use of skin-based nanomedical delivery methods may help reduce toxicity, improve sustained release and penetration(113, 114). Skin exposure to nanoparticles as pollution, antibacterials, and sun screen each have some toxicity concerns(115-117). Nanoparticle uptake measurements using quantum dots showed that penetration into the dermal layer is limited to the uppermost stratum corneum layers and the hair follicles(118).…”

Section: Toxicity: Delivery Modes Mechanisms and Managementmentioning

confidence: 99%

Convergence of Nanotechnology and Cancer Prevention: Are We There Yet?

Menter

Patterson

Logsdon

et al. 2014

Cancer Prevention Research

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Nanotechnology is emerging as a promising modality for cancer treatment; however, in the realm of cancer prevention, its full utility has yet to be determined. Here, we discuss the potential of integrating nanotechnology in cancer prevention to augment early diagnosis, precision targeting and controlled release of chemopreventive agents, reduced toxicity, risk/response assessment, and personalized point-of-care monitoring. Cancer is a multistep, progressive disease; the functional and acquired characteristics of the early precancer phenotype are intrinsically different from those of a more advanced anaplastic or invasive malignancy. Therefore, applying nanotechnology to precancers is likely to be far more challenging than applying it to established disease. Frank cancers are more readily identifiable through imaging and biomarker and histopathologic assessment than their precancerous precursors. In addition, prevention subjects routinely have more rigorous intervention criteria than therapy subjects. Any nanopreventive agent developed to prevent sporadic cancers found in the general population must exhibit a very low risk of serious side effects. In contrast, a greater risk of side effects might be more acceptable in subjects at high risk for cancer. Using nanotechnology to prevent cancer is an aspirational goal, but clearly identifying the intermediate objectives and potential barriers is an essential first step in this exciting journey.

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Effects triggered by platinum nanoparticles on primary keratinocytes

Cited by 22 publications

References 31 publications

Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro

Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro

Are platinum nanoparticles safe to human health?

Convergence of Nanotechnology and Cancer Prevention: Are We There Yet?

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