Effects on the Cardiovascular System of Fluids Administered Intravenously in Man

Altschule, Mark D.; Freedberg, A. Stone; McMANUS, Mary J.

doi:10.1001/archinte.1947.00220160070006

Cited by 3 publications

References 12 publications

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Effect of Electrically Induced Convulsions on Cutaneous Lymphatic Flow

Altschule¹,

Altschule²

1950

Arch NeurPsych

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EARLIER work afforded data which indicated that accelerated flow occurred in cutaneous lymphatics when the amount of tissue fluid increased during the intravenous administration of solutions of electrolytes.1 In view of the fact that fluid is lost from the circulation to the tissues during electrically induced convulsions,2 it was considered of interest to study the behavior of the lymphatics of the skin before and after such seizures.MATERIAL AND METHODS Ten patients, ranging in age from 18 to 64, were studied; 8 were women. All were psychotic, but the type and severity of the mental disease varied. None had evidence of impairment of cardiac, renal or thyroid function. The method used was that previously described 1 and consisted in measurements over a period of fifteen minutes of the areas of wheals made by injecting a 1 per cent solution of Evans blue (T 1824). One wheal was made approximately fifteen minutes before the seizure was induced; increases in its area before the convulsion were compared with changes in area after it. A second wheal was made immediately before induction of the seizure and was observed for fifteen minutes after the end of the convulsion. In 9 instances the wheals were made on the flexor surface of the forearm ; in the remaining 1 case they were placed over the medial aspect of the shin. OBSERVATIONSThe areas of the wheals made approximately fifteen minutes before the convulsion increased by 0 to 28 per cent in the period up to the induc¬ tion of the seizure; the average increase was 8 per cent. The increase From the

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