Effects on Rat Kidney Slice Function In Vitro of Proteins from the Urines of Patients with Myelomatosis and Nephrosis

Preuss, Harry G.; Weiss, F. R.; Iammarino, Richard M.; Hammack, William J.; Murdaugh, H. V.

doi:10.1042/cs0460283

Cited by 19 publications

(4 citation statements)

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“…In vivo, tubular type proteinuria, indicat ing proximal tubular dysfunction, has been found in the presence of urinary light chains [66]. Certain transport func tions of rat renal cortical slices have been shown to be altered by the presence of light chains extracted from urine [67,68], Transport functions of brush-border membrane vesicles from proximal tubular cells have also been in hibited by urinary light chains [69]. Whether these alter ations are indicative of cell injury is not known.…”

Section: Effects Of Proteinuria On Proximal Tubular Cell Functionsmentioning

confidence: 99%

Proximal Tubular Cell, Proteinuria and Tubulo-lnterstitial Scarring

Burton

Walls

1994

Nephron

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Section: Effects Of Proteinuria On Proximal Tubular Cell Functionsmentioning

confidence: 99%

Proximal Tubular Cell, Proteinuria and Tubulo-lnterstitial Scarring

Burton

Walls

1994

Nephron

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“…In another in vitro study, Preuss et al (30) investigated the effects of urinary proteins from patients with myeloma on renal tubular function. Urinary proteins from patients with myeloma had a generalized depressive effect on proximal tubular function while urinary proteins from nephrotic patients did not.…”

Section: Other Studiesmentioning

confidence: 99%

Differential Effects of Nephrotoxic Agents on Renal Transport and Metabolism by Use of In Vitro Techniques

Hirsch¹

1976

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives. A number of studies by the author and other investigators are reviewed in which the in vitro kidney slice technique has been used to evaluate the nephrotoxicity of various compounds. The kidney slice technique can be used to determine the effect of prior drug treatment of laboratory animals on renal organic acid (p-aminohippurate) or organic base (N-methylnicotinamide) transport, on glucose synthesis, and on oxygen consumption by renal coritical slices. The nephrotoxic agents uranyl nitrate and potassium dichromate exert inhibitory effects on renal function, although both agents enhance organic base transport at low doses and potassium dichromate enhances organic acid transport at moderate doses. Enhanced PAH transport has been found to be a sensitive indicator of gentamicin induced nephrotoxicity, while inhibition of other parameters has been reported. The tissue slice method is less effective in evaluating chronic nephrotoxicity such as that produced by lead. The inhibitory effect of mercurial diuretics has been shown to be due to the general depression of metabolic activity by mercury. The kidney slice technique has been found to be a sensitive indicator in the assessment of halogenated hydrocarbon-induced nephrotoxicity. Differential effects of compounds on in vitro organic acid and base trasport provides information about the transport of these compounds as well as about their nephrotoxicity.Although it is often desirable to perform in vivo tests or other in vitro renal function tests, the kidney slice technique has proved to be extremely useful in toxicological evaluations.

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“…At this time his blood urea and urine output were normal, although proteinuria was noted. Six weeks after antituberculous chemotherapy had been restarted, however, he was found to be in renal failure, with a serum creatinine concentration of 730 ,umoVI (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) mg/100 ml) and blood urea of 26 mmol/I (156.6 mg/100 ml). He was transferred for further investigation.…”

Section: Case Reportmentioning

confidence: 99%

Rifampicin induced light chain proteinuria and renal failure.

Winter¹,

Banks²,

Collins³

et al. 1984

Thorax

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Light chain proteinuria is a recognised cause of renal disease and renal failure.' In 1973 Graber etal described light chain proteinuria occurring in patients given rifampicin2 and there have since been two case reports of renal failure due to rifampicin induced light chain proteinuria.34 We report a third case, which with that of Warrington and others3 suggests that dehydration predisposes to this rare complication of rifampicin treatment. Case reportA 57 year old man presented with a three week history of haemoptysis and weight loss of 10 kg over nine months. His serum creatinine concentration was 45 ,umoIl, blood urea 9 5 mmoVI, plasma sodium 126 mmol(mEq)/l. Plasma and urine osmolalities were 267 and 685 mmol(mosm)/kg respectively. There was no proteinuria. A chest radiograph showed bilateral abnormal shadowing and direct smears of sputum stained positively for alcohol and acid fast bacili.Antituberculous treatment was started with rifampicin 600 mg, isoniazid 300 mg, and ethambutol 900 mg daily. For the first five days after presentation ampicillin (2 g/ day) was also given. He developed increasing confusion, which was attributed to the syndrome of inappropriate antidiuretic hormone secretion. Fluid restriction (800 ml/24 h) was started, and demeclocycline (600 mg/day) given. After nine days he developed an urticarial rash and all drugs were stopped; at that time renal function was normal and the plasma sodium concentration 129 mmol/l. Antituberculous treatment was restarted after three days and restriction of fluids to 800 ml a day continued.During the following month he showed a response to antituberculous treatment. At this time his blood urea and urine output were normal, although proteinuria was noted. Six weeks after antituberculous chemotherapy had been restarted, however, he was found to be in renal failure, with a serum creatinine concentration of 730 , mg/100 ml) and blood urea of 26 mmol/I (156.6 mg/100 ml). He was transferred for further investigation. There were red blood cells and tubular casts in the urine and proteinuria of 2-6 g in a 24 hour volume of 1100 ml. Immunoelectrophoresis of the urine showed free polyclonal K and X light chains and trace albumin. A direct antiglobulin test was weakly positive but there were no rifampicin dependent antibodies.A renal biopsy was carried out and showed an

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Effects on Rat Kidney Slice Function In Vitro of Proteins from the Urines of Patients with Myelomatosis and Nephrosis

Cited by 19 publications

References 0 publications

Proximal Tubular Cell, Proteinuria and Tubulo-lnterstitial Scarring

Proximal Tubular Cell, Proteinuria and Tubulo-lnterstitial Scarring

Differential Effects of Nephrotoxic Agents on Renal Transport and Metabolism by Use of In Vitro Techniques

Rifampicin induced light chain proteinuria and renal failure.

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