Effects on plaque acidogenicity of salivary factors and frequency of between-meal eating.

Ueda, Itsuo; Anbe, H; Nakao, Shinichiro

doi:10.5834/jdh.36.103

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Because not all orthodontic devices/approaches (e.g. self-ligating brackets, removable appliances) have the same predisposition to affect oral hygiene, we only included patients with a treatment plan that used archwires with self-ligating brackets and excluded those with elastomeric rings, since they make cleaning more difficult [ 36 – 40 ]. In this way, our study was designed to capture inherent differences in saliva in an orthodontic setting in a patient pool in which oral hygiene should be well maintained.…”

Section: Discussionmentioning

confidence: 99%

“…Stephan originally performed measurements in plaque, but as in our study, others have focused on salivary pH and pH recovery [ 22 , 36 – 39 ]. Salivary pH is a major factor controlling plaque pH [ 40 ]. In studies measuring salivary pH in healthy, caries-free/inactive individuals, baseline values ranged from 6.8 to 7.6, similar to our findings [ 37 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

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Pre-treatment oral microbiome analysis and salivary Stephan curve kinetics in white spot lesion development in orthodontic patients wearing fixed appliances. A pilot study

et al. 2023

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Background White spot lesions (WSLs) are a formidable challenge during orthodontic treatment, affecting patients regardless of oral hygiene. Multifactorial in nature, amongst potential contributors to their development are the microbiome and salivary pH. The aim of our pilot study is to determine if pre-treatment differences in salivary Stephan curve kinetics and salivary microbiome features correlate with WSL development in orthodontic patients with fixed appliances. We hypothesize that non-oral hygiene determined differences in saliva could be predictive of WSL formation in this patient population through analysis of salivary Stephan curve kinetics, and that these differences would further manifest as changes in the oral microbiome. Methods In this prospective cohort study, twenty patients with initial simplified oral hygiene index scores of “good” that were planning to undergo orthodontic treatment with self-ligating fixed appliances for at least 12 months were enrolled. At pre-treatment stage, saliva was collected for microbiome analysis, and at 15-minute intervals after a sucrose rinse over 45 min for Stephan curve kinetics. Results 50% of patients developed a mean 5.7 (SEM: 1.2) WSLs. There were no differences in saliva microbiome species richness, Shannon alpha diversity or beta diversity between the groups. Capnocytophaga sputigena exclusively and Prevotella melaninogenica predominantly were found in WSL patients, while Streptococcus australis was negatively correlated with WSL development. Streptococcus mitis and Streptococcus anginosus were primarily present in healthy patients. There was no evidence to support the primary hypothesis. Conclusions While there were no differences in salivary pH or restitution kinetics following a sucrose challenge and no global microbial differences in WSL developers, our data showed change in salivary pH at 5 min associated with an abundance of acid-producing bacteria in saliva. The results suggest salivary pH modulation as a management strategy to inhibit the abundance of caries initiators. Our study may have uncovered the earliest predecessors to WSL/caries development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pre-treatment oral microbiome analysis and salivary Stephan curve kinetics in white spot lesion development in orthodontic patients wearing fixed appliances. A pilot study

et al. 2023

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“…Moreover, buffering capacity increases with increasing liquid outflow. [9] Therefore, salivary secretion is promoted during swallowing because a higher salivary buffering capacity is required during swallowing than during presentation, which is affected only by the conditioned reflexes.…”

Section: Saliva Buffer Capacitymentioning

confidence: 99%

An effective salivation-facilitating method for COVID-19 testing: An experimental study

et al. 2023

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Background: Simple tools, such as antigen test kits, are readily available for determining coronavirus disease 2019 infection at hospitals and homes. However, it is challenging for elderly people who are prone to dry mouth and other diseases. The main objective of this study was to investigate whether the presence or consumption of a plum pickle can facilitate salivation during coronavirus disease 2019 testing. Method: Twenty healthy adult women participated in the study. The participants were allocated to 2 groups: presentation and non-presentation (n = 10; with and without presentation of a plum pickle, respectively), and eating and non-eating (n = 10; with and without consumption of plum pickle, respectively). We recorded the number of saliva swallows in 1 minute under each condition, using a swallowing test device, which attached film sensors to the hyoid bone and thyroid cartilage. Results: There was a significant difference in the number of swallows between the non-presentation and presentation groups (P < .01, r = 0.89, Z = −2.82) as well as between the non-eating and eating groups (P < .01, r = 0.85, Z = −2.68). Conclusions: The strength of 3 factors, namely: direct stimulation with citric acid, saliva buffer capacity, and motor learning, may have affected the results. Our study suggests that saliva collection using the plum pickle is an effective complementary method for facilitating salivation. This technique may be useful in avoiding the risk associated with citric acid intake and for efficient specimen collection during coronavirus disease 2019 testing. In the future, we need to verify this method in elderly participants in a clinical setting.

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Effects on plaque acidogenicity of salivary factors and frequency of between-meal eating.

Cited by 2 publications

References 23 publications

Pre-treatment oral microbiome analysis and salivary Stephan curve kinetics in white spot lesion development in orthodontic patients wearing fixed appliances. A pilot study

Pre-treatment oral microbiome analysis and salivary Stephan curve kinetics in white spot lesion development in orthodontic patients wearing fixed appliances. A pilot study

An effective salivation-facilitating method for COVID-19 testing: An experimental study

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