Effects on Monkeys of Introduction of Hemolytic Streptococci Into Root Canals

Kennedy, Donald R.; Hamilton, Tom R.; Syverton, Jerome T.

doi:10.1177/00220345570360040201

Cited by 34 publications

(7 citation statements)

References 21 publications

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“…The existence of immunoglobulin and completnent suggests that immune antigen-antibody complexes may be present. The antigens may be bacteria as shown by Kennedy et al, (1957) and the altered host tissue substances shown by Okada et al, (1967). Thus, when antigens are available in relatively high concentration in periapical granulomas, as in the case with opened root canal, the complexes may activate complement.…”

Section: Discussionmentioning

confidence: 99%

Pathologic study of periapical lesions 1. Periapical granulomas: clinical, histopathologic and immunohistopathologic studies

Yanagisawa

1980

J Oral Pathology Medicine

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Seventy periapieal granulomas were histopathologieally examined. They were divided into four types: exudative, granulomatous, granulo-fibrous, and fibrous types, Clinieopathologieally, those having marked lymphoeytie infiltration were found more frequently in eases having had endodontie treatment; further, the size of a radiolueent area did not exeeed that of the involved tooth erown. In eontrast, a predominant plasma eell infiltrate was more frequent in cases with open pulp ehambers (no treatment). In those eases, the radiolueent area was larger than the erown. Foei with very large radiolueent areas were often of the exudative type. Epithelial proliferation was more frequent in eases without treatment. These findings indieate that endodontie treatment not only stops invasion of injurious faetors but also proliferation of epithelium. Furthermore, in frozen seetions of 26 granulomas, IgE-containing eells and IgG and C, fluoreseenee in the eonneetive tissue were often observed. It appears that IgB-mediated reaetion and antigen-antibody eomplexes may play a role in periapieal pathosis.

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Section: Discussionmentioning

confidence: 99%

Pathologic study of periapical lesions 1. Periapical granulomas: clinical, histopathologic and immunohistopathologic studies

Yanagisawa

1980

J Oral Pathology Medicine

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“…These oral bacteria may cause transient bacteremias, which are common in dental procedures, but also occur in teeth brushing and even in chewing in the presence of poor oral health and accumulated plaque and gingivitis (De-Leo et al 1974, Murray & Moosnick 1941. A viable microflora in the root canal after pulp necrosis also causes transient bacteremias (Allard et al 1979, Kennedy et al 1957. Transient bacteremias may lead to complications, such as infective endocarditis, other systemic bacteremic infections and metastatic local infections, especially if the patient has predisposing factors to such infectious complications.…”

Section: Etiopathogenesis and Complications 01 Oral Iniect\onsmentioning

confidence: 99%

Vascular diseases and oral infections

Syrjänen

1990

J Clinic Periodontology

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Syrjken J: Vascular diseases and oral infections. J Clin Periodontoll990; 17: 497-500.Abstract. Vascular diseases are multifactorial, and several risk factors, such as increasing age, male sex, hypertension, diabetes, dyslipidemias and smoking, are well-known. In recent studies, associations have also been found between preceding infections and development of myocardial or cerebral infarction. Preceding acute respiratory infections are reported to be more common in patients with myocardial or cerebral infarction. Cerebral infarction may follow infective endocarditis, bacterial meningitis or any other bacteremic infection. Oral infections are common chronic bacterial infections. Although oral infections are local, they may lead to systemic infectious complications via stransient bacteremias, and there may also be other systemic effects, for instance, via immunologic or toxic mechanisms. Association between oral infections and vascular diseases has been studied in 2 Finnish case-control studies concerning myocardial and cerebral infarction. In these case-control studies, it was found that oral infections were more common in patients with myocardial or cerebral infarction than in their age-and sex-matched community controls. There are many factors, such as diabetes, smoking and alcohol abuse, which may predispose to both development of infarction and oral infections. Therefore, the observed association between oral infections and vascular diseases may result from these common predisposing factors, and causality between them cannot be inferred. There are, however, several possible links between oral infections and infarction. Although causality between oral infections and infarction cannot be proven, patients who have poor oral health need health education, paying attention to those common risk factors of oral infections and vascular diseases. Furthermore, their oral infections should be treated, because they may predispose to infectious complications, which may lead to infarction.

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“…Dental procedures implicated in infective endocarditis cases were reviewed over a 13-year period in the UK, and while most cases involved exodontia (17) or scaling (18), root canal treatment with extracanal instrumentation accounted for seven cases due to bacteremia. For many years, it has also been believed that bacteremias could arise from treatment of infected root canals (19)(20)(21)(22), less so in non-surgical than surgical procedures (18,23). During non-surgical root canal treatment, it has been estimated that the greatest risk of bacteremia occurs during the early phase when the canal is still infected and instruments are placed to the apical termini for length determination and/or canal preparation (17).…”

Section: Bacterial Endocarditismentioning

confidence: 99%