Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency

Ramiro-Lozano, José Manuel; Calvo-Romero, José Marı́a

doi:10.1177/2042018815599874

Cited by 26 publications

(11 citation statements)

References 18 publications

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“…Similar results were reported by various authors in their studies (11,12,13) . Wang et al also showed that raised levels of vitamin D were related with favorable lipid profile, whereas lower levels of vitamin D were related with atherogenic lipid profile (4) .…”

Section: Discussionsupporting

confidence: 82%

Diminished Levels of Vitamin D and Altered Lipid Profile

Mahajan¹

2017

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Section: Discussionsupporting

confidence: 82%

Diminished Levels of Vitamin D and Altered Lipid Profile

Mahajan¹

2017

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“…We found different data about influence of vitamin D on lipid status in literature 13,29,37 . All our patients had significantly decreased levels of total cholesterol and triglycerides after therapy.…”

Section: Discussionmentioning

confidence: 84%

Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus

et al. 2020

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Background/Aim. Vitamin D insufficiency/deficiency is often present in patients with type-2 diabetes mellitus (DM) and could present a risk factor for rapid progression of diabetic nephropathy and for higher incidence of cardiovascular events. The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. Therapy included six months of supplementation with cholecalciferol drops: first two months with 20,000 IU twice weekly, than if level of vitamin D was below normal the same dose was given next four months. If the level of vitamin D was normal 5,000 IU was given twice weekly. At the begining and at the end of the study the levels of urea, creatinine, fasting blood glucose, calcium, phosphorus, cholesterol, triglycerides, CRP, hemoglobin A1c, intact parathyroid hormone, 24-hour urine protein and creatinine clearance were determined. Levels of calcium, phosphorus and vitamin D were also checked 2 months after beginning of therapy due to possible correction of cholecalciferol dose. Results. The lowest level of vitamin D before therapy was found in patients with macroproteinuria, while at the end of the study the significantly higher level of vitamin D was found in all three groups. After 6 months of therapy a significant decrease of 24-hour urine protein, cholesterol, triglycerides, hemoglobin A1c in all three groups, and CRP in patients with normal proteinuria and microproteinuria were found. Significantly negative correlation between vitamin D and 24-hour urine protein, cholesterol and CRP was found in patients with macroproteinuria. Also, significantly negative correlation was found between vitamin D and hemoglobin A1c, in patients with normal proteinuria, vitamin D and CRP in patients with microproteinuria. Conclusion. A preventive use of high-dose cholecalciferol supplementation in patients with type-2 DM (with or without proteinuria) decreases cholesterol, triglycerides, proteinuria, CRP and hemoglobin A1c.

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“…Supplementation with 4000 IU/day vitamin D in postmenopausal women with type 2 diabetes mellitus (T2DM) for 6 months resulted in a significant decrease in serum triglyceride levels without affecting levels of other lipid profiles (Munoz-Aguirre et al, 2015). No significant change in circulating levels of triglycerides, LDL-and HDL-cholesterol was observed in patients with T2DM following supplementation with 16,000 IU of vitamin D orally once a week for 8 weeks (Ramiro-Lozano & Calvo-Romero, 2015). Favorable effects of vitamin D intake on markers of insulin resistance might be explained by its effect on calcium and phosphorus metabolism and through up-regulation of the insulin receptor genes (Maestro, Molero, Bajo, Davila, & Calle, 2002) and increased transcription of insulin receptor genes (Maestro et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

Razzaghi

Pourbagheri

Momen‐Heravi

et al. 2017

Journal of Diabetes and its Complications

139

123

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Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency

Abstract: Correction of vitamin D deficiency in type 2 diabetic patients decreases total cholesterol. Our results do not rule out reductions in LDL cholesterol, non-HDL cholesterol and triglycerides.

Cited by 26 publications

References 18 publications

Diminished Levels of Vitamin D and Altered Lipid Profile

Diminished Levels of Vitamin D and Altered Lipid Profile

Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus

The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

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