Effects on hemodynamic variables and echocardiographic parameters after a stellate ganglion block in 15 healthy volunteers

Abstract

Even with our methods we could not prevent the simultaneous occurrence of a partial parasympatholytic effect. For this reason, the SGB has only minor hemodynamic effects, which is desirable as it enhances the safety of the SGB.

Effects of ultrasound guided ganglion stellate blockade on intraoperative and postoperative hemodynamic responses in laparoscopic gynecologic surgery.

“…The role of stellate ganglion block is well known in patients with chronic pain because of the reduction in sympathetic tone, and prevention of central sensitization helping to have normal somatic sensation [20,21]. De La Vega Costa et al reported that SGB has minor effects on the hemodynamic status [22], which is similar to our study. In the current study we did not find major hemodynamic consequences in patients after performing SGB.…”

Efficacy of peripheral lidocaine application (neural therapy) in the treatment of neurogenic detrusor overactivity in multiple sclerosis patients

“…Beside the action on sodium ion channels, additional molecular mechanisms in NT have been revealed. Local anesthetics induce Gq‐protein‐complex mediated intracellular anti‐inflammatory mechanisms deactivate overactive granulocytes, inhibit the signaling of human N‐methyl‐D‐aspartate (NMDA) receptors, and affect the synthesis and release of inflammatory mediators as eicosanoids, histamine, prostaglandins, and cytokines …”

“…Local anesthetics also induce vasodilatation, reduce a pathologically increased capillary permeability, have antimicrobial properties, and exhibit a sympatholytic effect …”

“…Local anesthetics induce Gq-protein-complex mediated intracellular anti-inflammatory mechanisms deactivate overactive granulocytes, inhibit the signaling of human N-methyl-D-aspartate (NMDA) receptors, and affect the synthesis and release of inflammatory mediators as eicosanoids, histamine, prostaglandins, and cytokines. [24][25][26][27][28] The longstanding effect of local anesthetics cannot only be explained by their pharmacological effect, but pleiotropy (ie, the "alternative effects") of local anesthetics. 28 These other mechanisms can be listed as;…”

“…36,37 Local anesthetics also induce vasodilatation, reduce a pathologically increased capillary permeability, have antimicrobial properties, and exhibit a sympatholytic effect. 26,28,38,39,40 Empirically, the number of sessions is decided according to the patients' reply to treatment, changing from three to seven sessions. In current study, we applied five sessions to the patients, in order to standardize our protocol and achieve optimized results.…”