Effects on Growth of Rat Offspring Born From Dams Treated Subcutaneously With a Surfactant, Polyoxyethylene(10)nonylphenyl Ether(np-10), During Lactational Period
Abstract:A surfactant NP-10 was administered subcutaneously to Jcl:Wistar female rats at dose levels of 5, 20 and 80 mg/kg/day from date of birth to day 21 after birth of F1 offspring to assess its effects on the growth, behavior and functions of the offspring. For F0 dams, scab formation and loss of hair at the test substance administration site were observed in all treatment groups and induration of the skin at the test substance administration site in the 20 and 80 mg/kg groups in general condition and necropsy find… Show more
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