Effects on fetal and maternal temperatures of paracetamol administration during labour: a case–control study

Abstract

Running foot: Effect of paracetamol on temperature in labour Wilcoxon matched-pairs signed-ranks test and cross-sectional data with Mann-Whitney U test. Shapes of the temperature curves were compared with mixed-effect models statistics for repeated measurements. The main outcome measures were temperature changes after paracetamol. A two-tailed P <0.05 was considered significant. RESULTS:Prior to T0 maternal and fetal temperatures increased in the paracetamol group, but after T0 no significant changes (P ≥0.1) were seen when compared with Wilcoxon signedranks test. In the control group, both temperatures increased from T-60 and onwards. Deltatemperatures (fetal minus maternal temperature) remained unchanged in both groups. The mixed-effect models analyses showed a significant difference (P =0.01) in the shape of fetal temperature curves between the paracetamol and control groups, but no significant difference (P =0.4) in maternal temperature curve shapes.

Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage

“…Antipyretics rates were not reported; however, current data suggest that acetaminophen does not in fact decrease maternal or fetal temperature during labor. 24 Finally, our cohort had a higher rate of epidural analgesia (99%) than expected in nulliparous patients. 25 Since epidural analgesia is a potent risk factor for noninfectious maternal fever and intrauterine inflammation, [26][27][28] there may be differences in uterine response to infectious fever in women laboring without epidural analgesia.…”

Suspected clinical chorioamnionitis with peak intrapartum temperature <380C: the prevalence of confirmed chorioamnionitis and short term neonatal outcome

“…Our search did not identify published studies that examined the effect of prior use of paracetamol on the clinical picture of CA. Lesson T et al [ 57 ] . observed that in febrile parturients, paracetamol halted an increasing trend and stabilized the fetal temperature.…”

Particular features of labor activity at the presence of inflammation of the uterine layers and placental membranes

“…Shynlova et al (2020) [28] описано інтенсивну запальну інфільтрацію міометрія моноцитами, нейтрофілами та макрофагами напередодні пологів і зазначено, що запальні цитокіни, бактеріальні ліпополісахариди та безпосередньо моноцити можуть посилювати скорочення клітин міометрія та викликати гіпертонічну дисфункцію матки. Інші автори [29][30][31][32][33][34][35][36][37][38][39], навпаки, зауважували, що внутрішньоматкове запалення та/або гіпертермія, пов'язані з ХА, знижують скоротливість матки.…”