Effects on Dopaminergic Neurons are Secondary in COX-Deficient Locomotor Dysfunction in <i>Drosophila</i>

Abstract

Neuronal knockdown of a COX subunit produces locomotor defect in flies Specific subsets of cholinergic and glutamatergic (not DA) neurons are vulnerable Decreased tyrosine hydroxylase is a secondary or side effect Extensive neuronal cell death is not involved in the phenotype