Effects of Ω-3 (n-3) Fatty Acid Supplementation on Insulin Sensitivity in Horses

Hess, Tanja; Rexford, Jill; Hansen, D. K.; Ahrens, Nicolette; Harris, Mary; Engle, T. E.; Ross, Trinette Noel; Allen, Kim

doi:10.1016/j.jevs.2012.07.007

Cited by 19 publications

(12 citation statements)

References 41 publications

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“…Effects of n-3 PUFA supplementation on insulin sensitivity in horses (Hess et al, 2013) Dietary supplementation with n-3 PUFA has been shown to increase insulin sensitivity as described above. In order to test the hypothesis that supplementation with n-3 PUFA would improve insulin sensitivity, the same diets described for the previous study were fed to a group of 21 adult mares to test glucose and insulin dynamics.…”

Section: Specific Horse Studiesmentioning

confidence: 96%

“…In order to test the hypothesis that supplementation with n-3 PUFA would improve insulin sensitivity, the same diets described for the previous study were fed to a group of 21 adult mares to test glucose and insulin dynamics. Specific tests to determine insulin sensitivity (frequent sampling intravenous glucose tolerance tests) were performed on days 0, 30, 60, and 90 of supplementation (Hess at al., 2013).…”

Section: Specific Horse Studiesmentioning

confidence: 99%

“…Although a small number of insulin resistant mares were compared, further studies should be performed in a larger group of insulin resistant horses. If proven effective, supplementation with omega-3 fatty acids could help to reduce problems associated with insulin resistance in horses (Hess et al, 2013).…”

Section: Specific Horse Studiesmentioning

confidence: 99%

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Omega-3 fatty acid supplementation in horses

Hess

Ross-Jones

2014

R. Bras. Zootec.

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-Polyunsaturated omega-3 fatty acids (n-3 PUFA) are a family of essential fatty acids with many biological activities. These fatty acids are incorporated into cell membranes, changing their structural and functional characteristics. N-3 PUFA can act by modulating inflammatory responses at different levels. Omega-3 PUFA can be converted in the body to longer-chain n-3 PUFA at a limited rate and are differently converted in body systems. It appears that when specific longerchain n-3 PUFA are desired these need to be supplemented directly in the diet. In different species some evidence indicates a potential effect on improving insulin sensitivity. Recently, a novel class of n-3 PUFA-derived anti-inflammatory mediators have been recognized, termed E-series and D-series resolvins, formed from EPA and DHA, respectively. N-3 PUFA derived resolvins and protectins are heavily involved in the resolution of inflammation. Supplementation with n-3 fatty acids in horses may help manage chronic inflammatory conditions such as osteoarthritis, equine metabolic syndrome, laminitis, and thereby help to improve longevity of sport horse.

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Section: Specific Horse Studiesmentioning

confidence: 96%

Section: Specific Horse Studiesmentioning

confidence: 99%

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Omega-3 fatty acid supplementation in horses

Hess

Ross-Jones

2014

R. Bras. Zootec.

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“…Enrichment of the diet with ω-3 PUFA, e.g., by adding flaxseeds or flaxseed oil, may increase tissue sensitivity to insulin and prove effective in preventing diabetes. Promising results in this regard were obtained in an experiment on horses [37], in which insulin resistance is a significant problem. Insulin resistance in horses, which is linked to the development of diseases such as laminitis, osteochondrosis and metabolic syndrome, can result in serious production losses [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Flaxseed Oil Supplementation on the Redox Status, Haematological and Biochemical Parameters of Horses’ Blood

Sembratowicz

Zięba

Cholewińska

et al. 2020

Animals

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This study compared the effect of two dietary vegetable oils on plasma biochemical indices, haematological parameters, and redox status of horses. Forty riding horses (20 mares and 20 stallions) of the Malopolski breed were divided equally into two groups that were similar in terms of age, sex, and body weight (on average 530 ± 30 kg). The horses received soybean oil (SO) or flaxseed oil (FO) in the amount of 25 mL per 100 kg BW/day. After 60 days, blood was collected for biochemical and haematological analyses. The results show that horses receiving FO as compared to the SO group had significantly lower plasma levels of glucose, low density lipoprotein cholesterol, total cholesterol/high-density lipoprotein (HDL) ratio and triacylglycerols, as well as the activities of alanine aminotransferase and alkaline phosphatase. In turn, %HDL-TC and lactate dehydrogenase activity were significantly higher in the FO group. The inclusion of FO in the diet contributed to an increase in antioxidant indices: creatinine, vitamin C, copper, and zinc contents and also superoxide dismutase and catalase activities. The level of the end product of lipid peroxidation, i.e., malonyl dialdehyde, in the FO group as compared to the SO group was significantly lower. Moreover, FO caused an elevation in red blood cell indicators, lymphocyte count and lysozymes. In conclusion, FO exerts a beneficial effect by stimulating antioxidant defence mechanisms of horses and reducing the severity of oxidative stress. FO also improved the lipid profile and haematological parameters of the blood. The replacement of SO by FO is recommended based on these findings.

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“…As concentrações de glicose diminuíram no grupo suplementado. Uma possível explicação seria que o cromo, juntamente com omega 3, funcione como um fator de tolerância à glicose para auxiliar as funções de insulina, especificamente em relação ao metabolismo da glicose, anabolismo e ganho muscular (Vincent, 2007;Hess et al, 2013;Hodgson et al, 2014). O triptofano também se mostra importante na redução dos valores plasmáticos de glicose, reduzindo o estresse e, consequentemente, as concentrações de cortisol, como já demonstrado por Davis et al (2017).…”

Section: Discussionunclassified

Influência da suplementação nutricional sobre o metabolismo energético e enzimas musculares em cavalos de Team Penning

Tongu

Leite

Bizare

et al. 2018

Rev. Acad. Ciênc. Anim.

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O Team Penning (TP) é uma modalidade equestre que exige velocidade máxima. Nesse tipo de exercício ocorre o rápido consumo de energia pela via anaeróbica. Diversos suplementos têm sido desenvolvidos para melhorar o desempenho e diminuir lesões musculares em equinos atletas. Objetivou-se neste estudo avaliar a influência da suplementação com Tonnus JCR® nos parâmetros fisiológicos, metabolismo energético e muscular no treinamento de TP. Foram utilizados 12 equinos da raça Quarto de Milha, atletas de TP, separados em dois grupos, suplementado (GS) e não suplementado (GNS), avaliados em dois treinos. Foi realizado o exame físico, avaliação das concentrações plasmáticas de glicose e lactato, e concentrações séricas de creatinoquinase (CK), aspartato aminotransferase (AST) e lactato desidrogenase (LDH). As amostras de sangue foram colhidas durante e após os treinos em 12 diferentes momentos (M0 - M11). A suplementação foi realizada no intervalo entre os treinos. No segundo treino, verificou-se diminuição nas concentrações de glicose no GS quando comparado ao treino 1 (p = 0,01); no GNS não houve diferença entre os treinos (p = 0,13). Não houve diferença nas concentrações de lactato entre grupos e treinos. Os valores da concentração de CK no treino 1 não apresentaram diferença entre os grupos (p = 0,83) e momentos (p = 0,16). Quando comparadas as concentrações de CK entre os grupos no treino 2, observaram-se concentrações menores no GS (p = 0,02). Ao se comparar o GS antes e após a suplementação, as concentrações de CK foram menores no treino 2 (p = 0,01). No GNS não houve diferença entre os treinos (p = 0,51). As enzimas AST e LDH não diferiram entre os grupos nos treinos 1 e 2. Concluiu-se que a suplementação influenciou de forma positiva, diminuindo as concentrações de glicose e os níveis de CK, o que indica menor injúria muscular pós-treino.

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Effects of Ω-3 (n-3) Fatty Acid Supplementation on Insulin Sensitivity in Horses

Cited by 19 publications

References 41 publications

Omega-3 fatty acid supplementation in horses

Omega-3 fatty acid supplementation in horses

Effect of Dietary Flaxseed Oil Supplementation on the Redox Status, Haematological and Biochemical Parameters of Horses’ Blood

Influência da suplementação nutricional sobre o metabolismo energético e enzimas musculares em cavalos de Team Penning

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