Effects of γ-irradiation and accelerated aging on composition-structure–property relationships for radiopaque embolic microspheres

Kehoe, S.; Looney, Mark G.; Kilcup, Nancy; Tonkopi, Elena; Daly, Conal; Abraham, Robinson J.J.; Boyd, Daniel

doi:10.1016/j.jnoncrysol.2014.05.016

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Hasan et al [ 157 ] produced microspheres of a multi-component system (0.562SiO 2 –0.035CaO–0.188ZnO–0.068La 3 O 2 –0.042TiO 2 –0.035MgO–0.035SrO–0.035Na 2 O, mol%), which was radiopaque, biocompatible, and non-degradable, as required for the treatment and monitoring of the emboli. Kehoe et al [ 158 ] synthesized the same glass and emphasized the increase in the radiopacity values evaluated by a CT analysis, which was induced by the modifier ions such as zinc. In another work, the authors registered an increment from 3223 to 12,042 HU for this property of the glass [ 159 ].…”

Section: Radiopacifiers In Glasses and Glass-ceramicsmentioning

confidence: 99%

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or after medical procedures. The radiopacifiers are frequently heavy elements of the periodic table, such as Bi, Zr, Sr, Ba, Ta, Zn, Y, etc., or their relevant compounds that can confer enhanced radiopacity. Radiopaque bioceramics are also intriguing additives for biopolymers and hybrids, which are extensively researched and developed nowadays for various biomedical setups. The present work aims to provide an overview of radiopaque bioceramics, specifically crystalline, non-crystalline (glassy), and nanostructured bioceramics designed for applications in orthopedics, dentistry, and cancer therapy. Furthermore, the modification of the chemical, physical, and biological properties of parent ceramics/biopolymers due to the addition of radiopacifiers is critically discussed. We also point out future research lacunas in this exciting field that bioceramists can explore further.

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Section: Radiopacifiers In Glasses and Glass-ceramicsmentioning

confidence: 99%

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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“…[20][21][22] Due to the high temperature synthesis of ORP5, it is not possible to pre-load the particles with DOX for DEB-TACE procedures. To ameliorate this issue, it is proposed that ORP5 could be combined with an appropriate polymer to yield a composite material that is both radiopaque and suitable for DEB-TACE.…”

Section: Introductionmentioning

confidence: 99%

“…Recently a new type of bland embolization material, based on a highly radiopaque and biocompatible multicomponent zinc-silicate glass (named ORP5), has been proposed in the literature for treatment of arteriovenous malformations and hypervascularized tumors. 20–22 Due to the high temperature synthesis of ORP5, it is not possible to pre-load the particles with DOX for DEB-TACE procedures. To ameliorate this issue, it is proposed that ORP5 could be combined with an appropriate polymer to yield a composite material that is both radiopaque and suitable for DEB-TACE.…”

Section: Introductionmentioning

confidence: 99%

Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization

et al. 2015

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The purpose of this study was to synthesize and optimize intrinsically radiopaque composite embolic microspheres for sustained release of doxorubicin in drug-eluting bead transarterial chemoembolization. Using a design of experiments approach, 12 radiopaque composites composed of polylactic-co-glycolic acid and a radiopaque glass (ORP5) were screened over a range of compositions and examined for radiopacity (computed tomography) and density. In vitro cell viability was determined using an extract assay derived from each composition against the human hepatocellular carcinoma cell line, HepG2. Mathematical models based on a D-Optimal response surface methodology were used to determine the preferred radiopaque composite. The resulting radiopaque composite was validated and subsequently loaded with doxorubicin between 0 and 1.4% (wt% of polylactic-co-glycolic acid) to yield radiopaque composite drug-eluting beads. Thereafter, the radiopaque composite drug-eluting beads were subjected to an elution study (up to 168 h) to determine doxorubicin release profiles (UV-Vis spectroscopy) and in vitro cell viability. Radiopaque composites evaluated for screening purposes had densities between 1.28 and 1.67 g.cm(-3), radiopacity ranged between 211 and 1450HU and cell viabilities between 91 and 106% were observed. The optimized radiopaque composite comprised 23 wt% polylactic-co-glycolic acid and 60 wt% ORP5 with a corresponding density of 1.63 ± 0.001 g.cm(-3), radiopacity at 1930 ± 44HU and cell viability of 89 ± 7.6%. Radiopaque composite drug-eluting beads provided sustained doxorubicin release over 168 h. In conclusion, the mathematical models allowed for the identification and synthesis of a unique radiopaque composite. The optimized radiopaque composite had similar density and cell viability to commercially available embolic microspheres. It was possible to preload doxorubicin into radiopaque composite drug-eluting beads, such that sustained release was possible under simulated physiological conditions.

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“…Irregular BKSA16 particles (100-300 µm), were subjected to flame spheroidization using a propane oxygen flame to transform the morphology of the glass frit to a microsphere (described elsewhere [14]). After processing the glass microspheres were packaged dry clean containers and sterilized using gamma irradiation (average dose 30 kGy, Nordion, Ontario, Canada).…”

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confidence: 99%

Dissolution behaviour and imageability of ternary borate glasses for use in geniculate artery embolization

et al. 2021

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Sixteen borate glass compositions comprising K2O and SrO were screened, using a design of mixtures approach, to model compositional effects on dissolution, CT imageability, and MRI relaxivity (R2). Based on the characteristics of each network, together with dose determination and toxicological risk, the composition identified as BKSA16 was selected as a preferred composition for pre-clinical evaluations related to geniculate artery embolization (GAE). Accordingly, BKSA16 particles were subjected to a flame spheroidization process and recharacterized, including the evaluation of residual mass at 72 h in physiologically representative media along with clinical determinations of suspension time (ease of use). For both the irregular particles and microspheres residual mass was present at 72 h in physiologically representative media. Additionally, both the microspheres and irregular particles achieved suspension times deemed to be acceptable for clinical use. The collective data confirms that BKSA16 microspheres have a range of beneficial features (specifically both degradable and imageable) suited to GAE.

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Effects of γ-irradiation and accelerated aging on composition-structure–property relationships for radiopaque embolic microspheres

Cited by 5 publications

References 22 publications

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization

Dissolution behaviour and imageability of ternary borate glasses for use in geniculate artery embolization

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