EFFECTS OF Β-Sympathetic BLOCKADE ON NON-ESTERIFIED-FATTY-ACID AND CARBOHYDRATE METABOLISM AT REST AND DURING EXERCISE

Muir, G. G.; Chamberlain, Douglas; Pedoe, D.

doi:10.1016/s0140-6736(64)90862-1

Cited by 40 publications

(8 citation statements)

References 17 publications

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“…The release of FFA from adipose tissue is probably mediated by sympathetic stimulation and circulating catecholamines (Hamlin et al 1960). The pattern of the FFA response with exercise, in this study, is consistent with previous findings (Carlson and Pernow 196 1 ;Muir et al 1964). This response, namely, an initial fall with a gradual return toward or exceeding resting values, was observed with both treatments.…”

Section: Exercise Stress Responsessupporting

confidence: 92%

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Effects of Propranolol on Several Physiological Responses During Orthostatic and Exercise Stress in Healthy Male Subjects

Maksud¹,

Tristani²,

Coutts³

et al. 1971

Can. J. Physiol. Pharmacol.

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1971. Effects of propranolol on several physiological responses during orthostatic and exercise stress in healthy male subjects. Can. J. Physiol. Pharmacol. 49,[867][868][869][870][871][872] The effects of propranolol administration on several responses to orthostatic and exercise stress were examined in 16 healthy young men. Propranolol treatment resulted in a significantly lower heart rate response to orthostatic stress, while systolic and diastolic blood pressures were unaffected by the drug. Propranolol treatment resulted in a significant reduction in heart rate and minute ventilation during bicycle exercise. However, oxygen consumption and mean exercise endurance times were not significantly altered following propranolol treatment. The findings suggest that in healthy young male subjects the cardiac depressant effects of propranolo1 are compensated for, so that the oxygen uptake and work capacity are not seriously compromised. MAKSUD, M. S . , TRISTANI, F. E., COUTTS, K. D., BARBORIAK, J. J., et HAMILTON, L. H. 1971. Effects of propranolol on several physiological responses during orthostatic and exercise stress in healthy male subjects. Can. J. Physiol. Pharmacol. 49, 867-872. Chez 16 jeunes hommes sains, nous avons Ctudit l'effet du propranolol sur les rCponses B la position debout et B l'exercice. La traitement au propranolol produit une diminution significative de la friquence cardiaque, lors de position debout. Les pressions systoliques et diastoliques ne sont pas modifiCes. Le traitement au propranolol diminue aussi de fagon significative la frCquence cardiaque et la ventilation minute au cours de l'exercice sur bicyclette. Par contre, la consommation d'02 et la tolCrance ? il'exercice ne sont pas modifites. Ceci suggkre que chez le jeune homme sain, l'effet dkpresseur des bloqueurs p est cornpens6 de telle sorte que la capacitt de travail et la consommation d'02 ne sont pas mod56es.

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Section: Exercise Stress Responsessupporting

confidence: 92%

“…The decrease in resting FFA levels (pre-tilt) observed in this study following propranolol was about 20%. This value is less than the response reported by Muir et al (1964). Our data for FFA following 20 min of tilt were also lower than data reported by Hamlin et al (1960).…”

Section: The Effects Of Propranolol or Systemic Ar-contrasting

confidence: 87%

Effects of Propranolol on Several Physiological Responses During Orthostatic and Exercise Stress in Healthy Male Subjects

Maksud¹,

Tristani²,

Coutts³

et al. 1971

Can. J. Physiol. Pharmacol.

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“…It has been shown that during prolonged exercise, fatty acid mobilization does increase markedly (14)(15)(16). This effect appears to be mediated, in part, by increased activity of the sympathetic nervous system (12,17). It appears possible that the cumulative effects of daily, exercise-induced bouts of lipolysis could be responsible for the greater fat loss of the exercised animals.…”

Section: Discussionmentioning

confidence: 99%

Effects of weight changes produced by exercise, food restriction, or overeating on body composition

Oscai¹,

Holloszy²

1969

J. Clin. Invest.

120

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A B S T R A C T The body weight of rats was reduced by exercise or by restriction of food intake over a period of 18 wk. Body composition was studied to determine if exercise protects against the loss of lean tissue that can occur as a result of a negative caloric balance.Rats weighing 706 ±14 g were divided into four groups matched for weight. A baseline group was killed at the beginning of the study. An exercising group, fed ad lib., was subjected to a program of swimming. A sedentary, free-eating group was provided with food ad lib. Two sedentary, paired-weight subgroups were calorie restricted so that they lost weight at the same rate as the exercisers. The protein intake of one pairedweight subgroup was matched with that of the exercising group. The other sedentary, paired-weight animals ate the standard diet.There was no significant difference in body composition between the two sedentary, paired-weight subgroups which were, therefore, pooled for comparison with the other groups. The exercisers lost 182 ±19 g as a result of both an increase in caloric expenditure and a decrease in appetite. The sedentary, food-restricted animals lost an average of 182 ±18 g. The sedentary, freeeating animals gained 118 ±13 g. The carcasses of the exercised animals contained significantly less fat and more lean tissue than those of the sedentary, pairedweight animals, providing evidence for a fat mobilizing and protein conserving effect of exercise. The composition of the body substance lost by the exercising animals was 78% fat, 5% protein, 1% minerals, and 16% water, compared to 62% fat, 11% protein, 1% minerals, and 26% water for the sedentary, food-restricted rats.

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“…The metabolic changes that may be caused by these drugs, e.g. a reduction of circulating fatty acids [12], are not sufficiently known. Further investigations of this aspect, especially in connection with chronic administration, must be awaited.…”

Section: Discussionmentioning

confidence: 99%

Treatment of the Hyperkinetic Heart Syndrome with Propranolol

et al. 1966

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EFFECTS OF Β-Sympathetic BLOCKADE ON NON-ESTERIFIED-FATTY-ACID AND CARBOHYDRATE METABOLISM AT REST AND DURING EXERCISE

Cited by 40 publications

References 17 publications

Effects of Propranolol on Several Physiological Responses During Orthostatic and Exercise Stress in Healthy Male Subjects

Effects of Propranolol on Several Physiological Responses During Orthostatic and Exercise Stress in Healthy Male Subjects

Effects of weight changes produced by exercise, food restriction, or overeating on body composition

Treatment of the Hyperkinetic Heart Syndrome with Propranolol

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