Effects of β-agonist zilpaterol hydrochloride feeding and supplementation period on growth and carcass characteristics of Lori-Bakhtiari lambs

Vahedi, Vahid; Towhidi, Armin; Shahneh, Ahmad Zare; Sadeghi, Morteza; Zamani, F.; Dunshea, Frank R.

doi:10.1016/j.smallrumres.2014.01.005

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Concerning the carcass parameters, the pH parameters were similar for all treatments and within normal values for the fresh meat of lambs [33]. Only the ZH treatment showed a significant increase in LT muscle area, which has been well documented in other reports and explained by protein synthesis activation and repartitioning effect in LT muscle [8,34].…”

Section: Growth Performance and Carcass Characteristicssupporting

confidence: 80%

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Peña-Torres¹,

Castillo-Salas²,

Jiménez‐Estrada³

et al. 2022

J Anim Sci Technol

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Ferulic acid (FA) is a phytochemical with various bioactive properties. It has recently been proposed that due to its phytogenic action it can be used as an alternative growth promoter additive to synthetic compounds. The objective of the present study was to evaluate the growth performance, carcass traits, fiber characterization and skeletal muscle gene expression on hair-lambs supplemented with two doses of FA. Thirty-two male lambs (n = 8 per treatment) were individually housed during a 32 d feeding trial to evaluate the effect of FA (300 and 600 mg d −1 ) or zilpaterol hydrochloride (ZH; 6 mg d −1 ) on growth performance, and then slaughtered to evaluate the effects on carcass traits, and muscle fibers morphometry from Longissimus thoracis (LT) and mRNA abundance of β 2 -adrenergic receptor (β 2 -AR), MHC-I, MHC-IIX and IGF-I genes. FA increased final weight and average daily gain with respect to non-supplemented animals (p ˂ 0.05). The ZH supplementation increased LT muscle area, with respect to FA doses and control (p ˂ 0.05). Cross-sectional area (CSA) of oxidative fibers was larger with FA doses and ZH (p ˂ 0.05). Feeding ZH increased mRNA abundance for β 2 -AR compared to FA and control (p ˂ 0.05), and expression of MHC-I was affected by FA doses and ZH (p ˂ 0.05). Overall, FA supplementation of male hair lambs enhanced productive variables due to skeletal muscle hypertrophy caused by MHC-I up-regulation. Results suggest that FA has the potential like a growth promoter in lambs.

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Section: Growth Performance and Carcass Characteristicssupporting

confidence: 80%

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Peña-Torres¹,

Castillo-Salas²,

Jiménez‐Estrada³

et al. 2022

J Anim Sci Technol

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“…Iranian fat‐tailed sheep breeds, Zamiri and Izadifard (1995) and Nourozi et al (2008) reported a significant reduction in the fat‐tail weight in lambs that were treated with metaproterenol, a β‐adrenergic agonist. Moreover, lamb feeding with β‐adrenergic zilpaterol hydrochloride significantly increased L. dorsi muscle area and feed efficiency in Lori‐Bakhtiari lambs (Vahedi et al, 2014). In South African Mutton Merino and Shanxi Dam Line, the overexpression of ADRB3 gene has been identified in adipose tissues higher than in non‐adipose tissues (Wu et al, 2011).…”

Section: Other Important Candidate Genes With Positional and Function...mentioning

confidence: 99%

Genetic basis of muscle‐related traits in sheep: A review

et al. 2022

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Sheep is a major contributor to global food production among livestock and one of the great sources of red meat for human consumption. Several QTL and numerous genes with major and minor effects have been identified in association with the muscle characteristics in sheep breeds worldwide. Understanding the genetic background of growth and carcass-related traits in sheep is a major factor in increasing muscle growth, muscle hypertrophy and, eventually, meat production. This review concisely shows how major signaling pathways control skeletal muscle growth. Herein we aimed to discuss and summarize different research findings on genomic regions related to carcass traits and meat production in sheep. Several causative mutations with major effects on different muscle-related traits have been reported in various sheep breeds. A general overview of the studies on main candidate genes showed that some alleles have major phenotypic effects in different breeds with commercial and farm level usability. However, numerous genes with minor effects were also reported regarding the polygenic nature of muscle-related traits. The knowledge of the candidate genes involved in growth traits and their effects provides valuable information for breeding and selection of muscularity traits.

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“…Resultados similares reportaron López-Carlos et al (6) al no encontrar diferencias en PT, Glu ni Trig al suplementar dosis similares de CZ a las del presente estudio usando ovinos cruzados Dorper x Katahdin. Otros autores (17) reportaron que la adición de 0.20 mg•kg -1 de PV día -1 de CZ a ovinos de lana no modificó los niveles sanguíneos de Glu, Trig, PT ni Col, encontrando sólo una disminución en los niveles de Ur. También se ha mencionado que la administración de CZ en bovinos no modificó los metabolitos sanguíneos (8,18) .…”

Section: Recibido: 23/12/2018unclassified

Efecto de la adición de clorhidrato de zilpaterol genérico en el perfil bioquímico y hematológico de ovinos de pelo engordados en corral

Pérez

Avendaño‐Reyes

Cruz

et al. 2020

Rev. Mex. Cienc. Pecu.

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El objetivo fue evaluar la adición de clorhidrato de zilpaterol (CZ, genérico) en la dieta de ovinos de pelo de engorda, sobre variables hematológicas y bioquímicas como indicadores del estado de salud. Treinta y dos (32) corderos de pelo cruzados (Dorper x Pelibuey) se bloquearon por peso inicial y cuatro tratamientos y se asignaron aleatoriamente dentro de cada bloque: T1= dieta basal (grupo testigo), T2= dieta basal más 0.10 mg·kg-1 de PV d-1 de CZ (Grofactor®, Virbac México, Guadalajara, México), T3= dieta basal más 0.20 mg·kg-1 de PV d-1 de CZ y T4= dieta basal más 0.30 mg·kg-1 de PV d-1 de CZ. Se tomaron muestras de sangre los días 1, 15 y 30 del estudio. El perfil hematológico se estimó en muestras de sangre fresca, mientras que metabolitos, electrolitos y hormonas en muestras de suero. El diseño experimental fue bloques completos al azar y se efectuó análisis de polinomios ortogonales para determinar la tendencia de las respuestas a los niveles de CZ. Los niveles de colesterol y urea fueron mayores (P<0.05) en T3 que en T2; asimismo, el nivel de concentración corpuscular medio de hemoglobina fue mayor (P<0.05) en T1 que en T3, mientras que el ancho de distribución de eritrocitos fue mayor (P<0.05) en T2 y T3 que en T4. Los niveles de Na y el número de plaquetas mostraron tendencia lineal (P<0.05) a disminuir y aumentar, respectivamente, conforme los niveles de CZ aumentaron. Se observó tendencia cuadrática (P<0.05) en la concentración corpuscular media de hemoglobina y ancho de distribución de eritrocitos al aumentar la dosis de CZ (genérico). Las variables restantes no mostraron tendencias significativas a los niveles de CZ (genérico). Los valores de los perfiles bioquímico y hematológico se encontraron dentro del rango de referencia, lo que sugiere que la adición de CZ no alteró el estado de salud de corderos en engorda.

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Effects of β-agonist zilpaterol hydrochloride feeding and supplementation period on growth and carcass characteristics of Lori-Bakhtiari lambs

Cited by 7 publications

References 27 publications

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Genetic basis of muscle‐related traits in sheep: A review

Efecto de la adición de clorhidrato de zilpaterol genérico en el perfil bioquímico y hematológico de ovinos de pelo engordados en corral

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