Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study

Novielli, Chiara; Anelli, Gaia Maria; Lisso, Fabrizia; Marzorati, A.; Parrilla, Bina; Oneta, M.; Savasi, Valeria; Cetin, Irene; Mandò, Chiara

doi:10.1016/j.repbio.2020.10.002

Cited by 6 publications

(8 citation statements)

References 53 publications

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“…mtDNA content was assessed by real-time PCR normalizing the levels of a nonpolymorphic mitochondrial gene (Cytochrome β) to those of a single-copy nuclear gene (RNase P) [28]. Total DNA (30 ng) was analyzed in triplicate on the 7500 Fast Real-Time PCR system by using TaqMan chemistry (MT-CYB: Hs02596867_s1 and RNase P: 4316844; Thermo Fisher Scientific, Carlsbad, CA, USA).…”

Section: Mitochondrial Dna (Mtdna) Levelsmentioning

confidence: 99%

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

et al. 2021

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SARS-CoV-2 infection has been related to adverse pregnancy outcomes. A placental role in protecting the fetus from SARS-CoV-2 infection has been documented. Nevertheless, it is still unclear how the placenta is affected in SARS-CoV-2 infection. Here we assessed placental mitochondrial (mt) and oxidative features in COVID-19 and healthy mothers. mtDNA levels, DNA oxidative damage, expression levels of genes involved in antioxidant defenses, mitochondrial dynamics and respiratory chain subunits were investigated in placentas from singleton pregnancies of 30 women with SARS-CoV-2 infection during the third trimester (12 asymptomatic, 18 symptomatic) and 16 controls. mtDNA levels decreased in COVID-19 placentas vs. controls and inversely correlated with DNA oxidative damage, which increased in the symptomatic group. Antioxidant gene expressions decreased in SARS-CoV-2 mothers (CAT, GSS). Symptomatic cases also showed a lower expression of respiratory chain (NDUFA9, SDHA, COX4I1) and mt dynamics (DNM1L, FIS1) genes. Alterations in placental mitochondrial features and oxidative balance in COVID-19-affected mothers might be due to the impaired intrauterine environment, generated by systemic viral effects, leading to a negative vicious circle that worsens placental oxidative stress and mitochondrial efficiency. This likely causes cell homeostasis dysregulations, raising the potential of possible long-term effects.

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Section: Mitochondrial Dna (Mtdna) Levelsmentioning

confidence: 99%

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

et al. 2021

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“…More in detail, biological matrices that have a positive influence on female reproductive health include carbocyclic sugar ( 54 ), phytonutrients ( 55 – 57 ), organosulfur compound ( 54 , 58 ), hormones ( 59 , 60 ), neuropeptide ( 61 ), organic acids ( 62 ), and vitamins ( 58 ). On the contrary, components exerting a negative influence mostly include high glycemic index carbohydrates, large amount of animal protein, saturated fatty acids, and trans fatty acids, which are typical of the Western model of nutrition, which is closely related to increased oxidative stress ( 4 , 5 , 53 ).…”

Section: Resultsmentioning

confidence: 99%

High-fat diet-negative impact on female fertility: from mechanisms to protective actions of antioxidant matrices

Di Berardino,

Barceviciute,

Camerano Spelta Rapini

et al. 2024

Front. Nutr.

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IntroductionExcessive calorie intake poses a significant threat to female fertility, leading to hormonal imbalances and reproductive challenges. Overconsumption of unhealthy fats exacerbates ovarian dysfunction, with an overproduction of reactive oxygen species causing oxidative stress, impairing ovarian follicle development and leading to irregular ovulation and premature ovarian failure. Interest in biological matrices with high antioxidant properties to combat diet-related oxidative stress has grown, as they contain various bioactive factors crucial for neutralizing free radicals potentially preventing female reproductive health. This systematic review evaluates the female reproductive impact of biological matrices in mitigating oxidative damages induced by over calory habits and, in particular, high fat diets.MethodsA comparative approach among mammalian models was utilized to interpret literature available data. This approach specifically investigates the antioxidant mechanisms of biological matrices on early and late ovarian folliculogenesis, under physiological and hormone-induced female reproductive cycle. Adhering to the PRISMA 2020 guidelines, only English-language publications from peer-reviewed international indexes were considered.ResultsThe analysis of 121 publications meeting the inclusion criteria facilitated the identification of crucial components of biological matrices. These components, including carbocyclic sugars, phytonutrients, organosulfur compounds, and vitamins, were evaluated for their impact on ovarian follicle resilience, oocyte quality, and reproductive lifespan. The detrimental effects of oxidative stress on female fertility, particularly exacerbated by high saturated fat diets, are well-documented. In vivo studies across mammalian preclinical models have underscored the potential of antioxidants derived from biological matrices to mitigate diet-induced conditions. These antioxidants enhance steroidogenesis and ovarian follicle development, thereby improving oocyte quality. Additionally, discussions within these publications emphasized the clinical significance of these biological matrices, translating research findings into practical applications for female health.ConclusionFurther research is essential to fully exploit the potential of these matrices in enhancing female reproduction and mitigating the effects of diets rich in fatty acids. This requires intensified in vitro studies and comprehensive collection of in vivo data before clinical trials. The promotion of ovarian resilience offers promising avenues for enhancing understanding and advancing female reproductive health world-wide.

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“…Moreover, antioxidant supplementation has been indicated as a potential strategy for improving reproductive outcomes in obese women. Studies suggest that antioxidants such as α-lipoic acid and myo-inositol may ameliorate oxidative stress in the oocyte environment, potentially contributing to improved fertility ( 65 ). Beyond these, the focus is also shifting towards drugs that target adipokines or their receptors.…”

Section: Weight Loss As a Therapeutic Strategy For Infertility In Obe...mentioning

confidence: 99%

Obesity and its impact on female reproductive health: unraveling the connections

Zheng,

Yang,

Guo

et al. 2024

Front. Endocrinol.

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In the modern era, the escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, has evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, female infertility is rising as a significant global health issue. Obesity, with its extensive systemic effects, is pinpointed as a major disruptor. The convergence of these health challenges reveals a multifaceted scenario: on one hand, obesity directly impacts female reproductive health, particularly in the context of conditions like polycystic ovary syndrome (PCOS) and menstrual disturbances; on the other, the psychosocial consequences of infertility might intensify weight-gain patterns, forming a challenging cycle. Additionally, the economic implications of treating obesity-related infertility are considerable. This review delves into the myriad ways obesity affects female reproductive health, drawing insights from epidemiological, clinical, and molecular studies. It explores the epidemiological relationship between obesity and PCOS, the influence of obesity on menstrual disturbances, and the broader impact of obesity on female infertility. Weight loss, through pharmacological interventions, surgical methods, or lifestyle adjustments, emerges as a promising strategy. Lastly, the efficacy of assisted reproductive technologies, such as IVF, is influenced by obesity, underscoring the importance of an optimal body mass index. The review also highlights the molecular and physiological mechanisms underlying the impact of obesity on female reproductive health, including the disruption of the hypothalamic-pituitary-ovary axis, altered adipokine secretion, and the role of chronic inflammation and oxidative stress.

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Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study

Cited by 6 publications

References 53 publications

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

High-fat diet-negative impact on female fertility: from mechanisms to protective actions of antioxidant matrices

Obesity and its impact on female reproductive health: unraveling the connections

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