Effects of Zopiclone on Japanese Elderly Insomnia Patient With Cerebrovascular Disorder Assesed by Sleep Wave and Eeg-Mapping.

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

“…In addition, we demonstrated stimulation of stage 4 by zopiclone in elderly subjects. An increase of slow wave sleep has already been reported from study samples of young volunteers (Tiberge et al 1988;Billiard et al 1989;Kanno et al 1993;Yamadera et al 1997) and insomniacs (Jovanovic and Dreyfus 1983;Katsunuma et al 1992;Eligulashvili et al 1997), although some studies report negative results (Fleming et al 1988;Pecknold et al 1990;Mann et al 1992), probably due to a ceiling effect, as SWS is already substantially present in younger healthy subjects (Lauer et al 1991).…”