Effects of Zingiber cassumunar (Plai cream) in the treatment of delayed onset muscle soreness

Manimmanakorn, Nuttaset; Manimmanakorn, Apiwan; Boobphachart, Disaphon; Thuwakum, Worrawut; Laupattarakasem, Wiroon; Hamlin, Michael J.

doi:10.1016/s2095-4964(16)60243-1

Cited by 18 publications

(23 citation statements)

References 13 publications

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“…Zingiber officinale roscoe (4 g) once daily for 5 days. consumption of 2 g of raw and heat-treated ginger (Black et al, 2010;Manimmanakorn et al, 2016). A useful alternative seems to be the topical administration of Zingiber cassumunar in 14% concentration (Manimmanakorn et al, 2016).…”

Section: Delayed Onset Muscle Sorenessmentioning

confidence: 99%

Clinical trials on pain lowering effect of ginger: A narrative review

Rondanelli

Fossari

Vecchio

et al. 2020

Phytotherapy Research

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Ginger has a pain-reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX-pathways, antioxidant activity, inibition of the transcription factor nf-kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10-year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever for dysmenorrhea, delayed onset muscle soreness (DOMS), osteoarthritis (AO), chronic low back pain (CLBP), and migraine. Regarding dysmenorrhea, six eligible studies suggest a promising effect of oral ginger. As concerned with DOMS, the four eligible RCTs suggested a reduction of inflammation after oral and topical ginger administration. Regarding knee AO, nine RCTs agree in stating that oral and topical use of ginger seems to be effective against pain, while other did not find significant differences. One RCT considered the use of ginger in migraine and suggested its beneficial activity. Finally, one RCT evaluated the effects of Swedish massage with aromatic ginger oil on CLBP demonstrated a reduction in pain. The use of ginger for its pain lowering effect is safe and promising, even though more studies are needed to create a consensus about the dosage of ginger useful for long-term therapy. K E Y W O R D S chronic low back pain, dysmenorrhea, ginger, knee osteoarthritis, myalgia, pain 1 | INTRODUCTION Zingiber officinale Roscoe (Zingiberaceae family), commonly known as ginger is a climbing perennial plant, indigenous to southeastern Asia. Ginger extract is a mixture of many biologically active constituents (Grzanna, Lindmark, & Frondoza, 2005). These compounds are numerous and vary depending on the place of origin and whether the rhizomes are fresh or dry (Ali, Blunden, Tanira, & Nemmar, 2008). More than 400 chemical substances have been isolated and identified in ginger rhizomes extracts, and new ones are still being discov

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Section: Delayed Onset Muscle Sorenessmentioning

confidence: 99%

Clinical trials on pain lowering effect of ginger: A narrative review

Rondanelli

Fossari

Vecchio

et al. 2020

Phytotherapy Research

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“…It is known in Thailand as Plai. Traditionally, the extract and the essential oil from the rhizome of Plai have been used in topical preparations to treat pain and inflammation in muscles and joints [1][2][3]. Phenylbutanoid compounds are the main active ingredients in Plai oil and Plai extract, responsible for the anti-inflammation activity [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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A controlled release system of Plai (Zingiber cassumunar Roxb.) oil based on electrospun poly(lactic) acid (PLA) nanofiber mat was successfully developed. The physicochemical properties of the nanofibers loaded with select amounts of oil (15%, 20%, and 30% wt) were characterized using various techniques, including a morphological study using scanning electron microscopy (SEM), structural determination using Fourier transform infrared spectrometry (FTIR) and x-ray diffraction (XRD), as well as thermal properties study using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The loading content and the entrapment efficiency of Plai oil within the fiber mats were evaluated and were found to be remarkably high, ensuring that PLA was an appropriate material for Plai oil loading. The ability of the nanofiber mats to release (E)-1-(3,4dimethoxyphenyl) butadiene (DMPBD) was also examined and the fiber mats showed controlled release characteristics. As the nanofiber mats have particularly high specific surface area with fully accessible and interconnected pore structures, a liquid medium with active ingredients will not be trapped in blind pores but can be fully released out of the fiber matrix. Furthermore, in vitro skin permeation of the active compound as well as a skin irritation were assessed using reconstructed human epidermis (EpiSkin TM ). It was found that DMPBD could efficiently penetrate through the skin model. Moreover, the nanofiber mats containing Plai oil also showed no skin irritation, indicating them as promising prototypes for medical applications.

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“…15 Previous clinical studies of topical formulations of Plai cream performed by essential oil of Z. montanum confirm that volunteers reported the effectiveness of Plai applications as a muscle pain treatment. 11,16 Diclofenac sodium is the NSAIDs that relieves muscle pain by inhibiting the activity of COX influencing prostaglandins synthesis in the arachidonic acid metabolism pathway. In the case of the placebo oil, the volunteers also evaluated the placebo oil as giving significant relief to muscle pain when compared to the baseline.…”

Section: Discussionmentioning

confidence: 99%

“…Plygesal cream containing 14.0% Plai essential oil showed an obvious effectiveness in ankle inflammation treatment 10 , a result that correlates well with a recent clinical study that reported the effectiveness of an emulsion containing 14.0% essential Plai oil for decreasing muscle soreness after exercise. 11 For a long time, Thai traditional medicine has used Plai oil for treating muscle inflammation and arthritis. Doctors of Thai traditional medicine have prepared Plai oil by frying the fresh rhizomes of Z. montanum 12 together with plant fixed oil.…”

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confidence: 99%

Effectiveness of a Plai Oil Prepared by Thai Traditional Medicine Process in the Treatment of Myofascial Pain Syndrome: A Randomized Placebo Controlled Trial

Wisuitiprot¹,

Bumrungchaichana²,

Kaewtai³

et al. 2019

J Health Sci Med Res

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Objective: To evaluate the effectiveness of Plai oil for treating myofascial pain syndrome.Material and Methods: One hundred and fourteen volunteers with muscle pain from myofascial pain syndrome participated in the study and had Plai oil, placebo oil and diclofenac gel applied to their shoulder and neck for 6 days. Clinical evaluation was determined using visual analogue scales, pressure threshold and cervical range of motion of neck flexion and neck extension measurements.Results: The results showed that the visual analogue scales of the 3 groups were significantly different from the baseline. The pressure threshold also increased significantly from the baseline (3.87±1.36) in the volunteers who applied Plai oil (4.42±1.34) and those who applied diclofenac gel (4.35±1.06). However, the results of treatment and placebo groups at the last follow-up were not significantly different. Interestingly, it was observed that Plai oil and placebo oil significantly increased the angle of neck flexion and extension within 3 days of application. Muscle pain treatment with Plai oil resulted in a good outcome that was no different to the outcome of applying the diclofenac gel and placebo.Conclusion: It was demonstrated that Plai oil is as effective for relieving myofascial pain as 1.0% diclofenac gel.The interpreted results of muscle pain are not fully clarified due to placebo effect and other influencing parameters. However, Plai oil also decreased muscle tension and improved the restricted range of motion. We can recommend that Plai oil can be used as an alternative topical application for muscle pain treatment.

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Effects of Zingiber cassumunar (Plai cream) in the treatment of delayed onset muscle soreness

Cited by 18 publications

References 13 publications

Clinical trials on pain lowering effect of ginger: A narrative review

Clinical trials on pain lowering effect of ginger: A narrative review

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Effectiveness of a Plai Oil Prepared by Thai Traditional Medicine Process in the Treatment of Myofascial Pain Syndrome: A Randomized Placebo Controlled Trial

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