Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment

Takaoka, T; Sarukura, Nobuko; Ueda, Chizuru; Kitamura, Yoshiaki; Kalubi, Bukasa; Toda, Naoki; Abe, Kōji; Yamamoto, Shigeru; Takeda, Noriaki

doi:10.1016/j.anl.2009.07.003

Cited by 32 publications

(14 citation statements)

References 24 publications

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“…These findings were in line with our previous conclusion that the ACE ratio is a more sensitive indicator than the concentration of zinc in the serum in evaluating dietary zinc nutrition (18)(19)(20).…”

Section: Discussionsupporting

confidence: 92%

“…Recently, we developed a new test for the assessment of zinc deficiency taking the ratio of apo/holoactivities of angiotensin converting enzyme (ACE), a zinc dependent enzyme, as an index, suggesting that the ratio of apo/holo-ACE activities (ACE ratio) is a more sensitive index of zinc nutrition than measuring zinc concentration in the serum (18)(19)(20). In the present study, we first examined the daily zinc intake from each food group in healthy Japanese living in the central area of Japan (Nagano prefecture) by means of the 72-h recall method.…”

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confidence: 99%

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Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan

et al. 2011

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan

et al. 2011

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“…[5,20,[48][49][50][51] This finding was supported in the research done by Najafizade et al [3,5] However it is important to notice at this point that both of the study had some limitations including smaller sample size, it used recognition threshold to measure taste acuity and studied only on head and neck cancer survivors. In contrast to the study of Najafizade et al, there are statistically robust studies in this review which high lights its side effects and ineffectiveness to prevent dysgeusia in cancer patients.…”

Section: Discussionmentioning

confidence: 64%

Management of Dysgeusia related to Cancer

Munankarmi

2017

J Lumbini Med Coll

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a ----------------------------------------------- ABSTRACT:Introduction: Taste change due to cancer is a notorious side effect, adversely affecting appetite and weight. Even though taste change or dysgeusia is one of the major causes of poor nutritional status in cancer survivors, it is not addressed as a significant problem and is often left untreated. The main purpose of this review is to explore current knowledge of pharmacological and behavioral interventions for the treatment of cancer related taste change. Methods: This systematic review was conducted in accordance with PRISMA guidelines to identify original articles on taste change. Multiple databases including; Scopus, Medline, EMBASE, CINAHL, and all databases via Pro quest were searched for original articles or studies related to taste change caused by cancer or its treatment. Relevant articles were subjected to a full text evaluation and assessed by Critical appraisal skills program (CASP) guidelines and the Effective public health practice project (EPHPP) instrument. Results: The search revealed 12 eligible studies, six of which were randomized controlled trials. Most of the studies used a standardized validated tool to measure taste change. Dysgeusia is common in cancer, 14 to 100% cancer patient report it. Pharmacological management with zinc remains inconclusive as one study reports it as beneficial and two other studies reported null effect. Few studies suggested dietary modifications such as use of sugary, salty foods that are helpful to reduce the effect of dysgeusia. Conclusion: Dietary counseling and informing the patient well about self-care strategies before treatment has consistently shown positive results on taste change, with strong statistical power. Other potential treatments for dysgeusia such as zinc, amifostine, and megestrol acetate gave inconsistent results.

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“…In animal models, MMF inhibits NADPH-oxidase, thereby inhibiting oxidative stress [134]. In patients with carotid artery stenosis, 2 weeks of MMF therapy resulted in increased numbers of regulatory T cells and decreased plaque expression of inflammatory genes [102].…”

Section: The Impact Of Modulators Of Lupus Disease Activity On Cardiomentioning

confidence: 99%

Pathogenesis and Treatment of Atherosclerosis in Lupus

McMahon¹,

Skaggs²

2014

Rheumatic Disease Clinics of North America

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Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment

Cited by 32 publications

References 24 publications

Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan

Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan

Management of Dysgeusia related to Cancer

Pathogenesis and Treatment of Atherosclerosis in Lupus

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