Effects of Zinc Supplementation on Vertebral and Femoral Bone Mass in Rats on Strenuous Treadmill Training Exercise

Seco, C.; Revilla, M.; Hernández, E. R.; Gérvas, J. J.; González-Riola, J.; Villa, L. F.; Rico, H.

doi:10.1359/jbmr.1998.13.3.508

Cited by 29 publications

(19 citation statements)

References 47 publications

(45 reference statements)

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“…Because of the influence of weight on bone mass [11], femur BMC was corrected for the animals final body weight (femur BMC/FW mg/g). As in our earlier studies [11][12][13][14], we have relied on DXA (Norland XR-26, Norland Co., Fort Atkinson, Wisconsin, USA). Our coefficients of variation (CV) for the current measurements, determined by six separate measurements done on three rat femurs and 5th vertebras at intervals of 3-4 days were 0.8% and 0.7%, respectively.…”

Section: Morphometric and Densitometric Studiesmentioning

confidence: 99%

“…The usefulness of dual-energy X-ray absorptiometry (DXA) for bone-mass determinations in small animals has been validated repeatedly [10] and our team had relied extensively on this technique in previous experimental studies [11,12]. More recently [13], we have demonstrated that zinc exerts a powerful influence by inhibiting the loss of bone mass in rats subjected to strenuous physical exercise. In view of these assertions, the present study was centered on the verification of the effect of Si on the bone mass loss through ovariectomy practiced on rats.…”

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confidence: 99%

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Effect of Silicon Supplement on Osteopenia Induced by Ovariectomy in Rats

Rico

Gallego-Lago

Hernández

et al. 2000

Calcified Tissue International

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The effect of silicon (Si) supplement on preventing bone mass loss induced by ovariectomy (OVX) in rats was investigated. Three groups of 15, 100-day-old female Wistar rats each, with a mean initial weight of approximately 260 g per animal, were selected for the present study. One of the experimental group consisting of 15 OVX rats was fed a diet supplemented with 500 mg of Si per kg of feed (Si + OVX). The other two groups consisting of 15 OVX and 15 sham-OVX rats did not receive these supplements. Morphometric (weight and length) and densitometric studies with dual-energy X-ray absorptiometry were performed on the whole femur and 5th lumbar vertebra of each animal 30 days after the experiment. The Si + OVX rats did not show a loss of bone mass induced by OVX at axial level (5th lumbar vertebra) or periphery (femur). Nonetheless, a significant increase (ANOVA with Bonferroni/Dunn post hocs test) of longitudinal development of the femur (P < 0.0001) was patent. These results, obtained through the measurements of axial and peripheral bones, warrant closer scrutiny in connection with the Si inhibitory effect on bone mass loss as well as the stimulatory effect on bone formation. Both actions, namely, inhibition of resorption and stimulation of formation, infer that Si may have a potential therapeutic application in the treatment of involutive osteoporosis.

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Section: Morphometric and Densitometric Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Silicon Supplement on Osteopenia Induced by Ovariectomy in Rats

Rico

Gallego-Lago

Hernández

et al. 2000

Calcified Tissue International

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“…In female rats strenuously exercising on a treadmill the length, weight, bone mineral content (BMC), and bone mineral density (BMD) of the femur was lower in animals receiving a normal diet, compared to those receiving a zinc supplemented diet 47 .…”

Section: Is There An Interaction Between Exercise and Diet?mentioning

confidence: 99%

Physical activity, diet and skeletal health

Branca

1999

Public Health Nutr.

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Diet and physical exercise concur in the determination of skeletal mass at the end of adolescence and in the conservation of it during adult life. The functional demand imposed on bone is a major determinant of its structural characteristics. Stress applied to a skeletal segment affects the geometry of the bone, the microarchitecture and the composition of the matrix. The stimulatory effect occurs when the skeleton is subjected to strains exceeding habitual skeletal loads, and the intensity of load is more important than the duration of the stimulus.Physical activity leads to greater bone density in children and adolescents and, to a minor extent, in adults. Weight bearing activities, such as walking, have a greater effect than non weight bearing activities, such as cycling and swimming. Reduction of loads as in bed resting or in space flights leads to bone loss. Intense training may cause damage, promptly repaired, as in stress fractures observed in army recruits. Female athletes may experience oligo-amenorrhea, though they still have a positive bone balance.There is an important interaction between the mechanical demands and the availability of nutrients to manufacture bone tissue. The increase in bone density in post-menopausal women is positively related to calcium intake when calcium supplementation is accompanied by exercise. When mechanical demands are low, such as during immobilisation, the intestinal calcium absorption is reduced. Calcium intake should also be analysed in the light of other dietary factors affecting the balance between absorption and excretion, and in combination with a number of other minerals, trace elements and bioactive substances with an impact on bone metabolism.

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“…Attempts to remedy low BMD in men through nutritional interventions have included zinc (Zn), with dietary Zn intake and plasma Zn both having a positive association with BMD [14]. Additionally, dietary Zn has been shown to improve BMD in humans [14][15][16][17][18] and in rats [19][20][21][22]. However, the influences of variations in Zn bioavailability and voluntary exercise levels as well as the associated combined effects of these influences on BMD have not been well documented.…”

Section: Introductionmentioning

confidence: 99%